Imperial College London
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DrTimothyDawes

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 3298tim.dawes Website

 
 
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Location

 

MRC London Institute of Medical Sciences, 111 ISDRobert Steiner MR unitHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dawes:2016:10.1161/CIRCIMAGING.116.005321,
author = {Dawes, TJW and Corden, B and Cotter, S and de, Marvao A and Walsh, R and Ware, J and Cook, SA and O'Regan, DP},
doi = {10.1161/CIRCIMAGING.116.005321},
journal = {Circulation-Cardiovascular Imaging},
title = {Moderate Physical Activity in Healthy Adults is Associated with Cardiac Remodeling},
url = {http://dx.doi.org/10.1161/CIRCIMAGING.116.005321},
volume = {9},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background—Cardiac mass and volumes are often elevated in athletes, but it is not known whether moderate physical activity is also associated with cardiac dilatation and hypertrophy in a healthy adult population.Methods and Results—In total, 1096 adults (54% female, median age 39 years) without cardiovascular disease or cardiomyopathy-associated genetic variants underwent cardiac magnetic resonance imaging to determine biventricular volumes and function. Physical activity was assessed using a validated activity questionnaire. The relationship between cardiac parameters and activity was assessed using multiple linear regression adjusting for age, sex, race, and systolic blood pressure. Logistic regression was performed to determine the effect of activity on the likelihood of subjects having cardiac dilatation or hypertrophy according to standard cardiac magnetic resonance normal ranges. Increasing physical activity was associated with greater left ventricular (LV) mass (β=0.23; P<0.0001) and elevated LV and right ventricular volumes (LV: β=0.26, P<0.0001; right ventricular: β=0.26, P<0.0001). Physical activity had a larger effect on cardiac parameters than systolic blood pressure (0.06≤β≤0.21) and a similar effect to age (−0.20≤β≤−0.31). Increasing physical activity was a risk factor for meeting imaging criteria for LV hypertrophy (adjusted odds ratio 2.1; P<0.0001), LV dilatation (adjusted odds ratio 2.2; P<0.0001), and right ventricular dilatation (adjusted odds ratio 2.2; P<0.0001).Conclusions—Exercise-related cardiac remodeling is not confined to athletes, and there is a risk of overdiagnosing cardiac dilatation or hypertrophy in a proportion of active, healthy adults.
AU  - Dawes,TJW
AU  - Corden,B
AU  - Cotter,S
AU  - de,Marvao A
AU  - Walsh,R
AU  - Ware,J
AU  - Cook,SA
AU  - O'Regan,DP
DO  - 10.1161/CIRCIMAGING.116.005321
PY  - 2016///
SN  - 1942-0080
TI  - Moderate Physical Activity in Healthy Adults is Associated with Cardiac Remodeling
T2  - Circulation-Cardiovascular Imaging
UR  - http://dx.doi.org/10.1161/CIRCIMAGING.116.005321
UR  - http://hdl.handle.net/10044/1/34614
VL  - 9
ER  -
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