Publications
221 results found
Williams TJ, 2004, The eosinophil enigma, JOURNAL OF CLINICAL INVESTIGATION, Vol: 113, Pages: 507-509, ISSN: 0021-9738
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- Citations: 52
Buckland KF, Williams TJ, Conroy DM, 2003, Histamine induces cytoskeletal changes in human eosinophils <i>via</i> the H<sub>4</sub> receptor, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 140, Pages: 1117-1127, ISSN: 0007-1188
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- Citations: 169
Martin C, Burdon PCE, Bridger G, et al., 2003, Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence, IMMUNITY, Vol: 19, Pages: 583-593, ISSN: 1074-7613
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- Citations: 522
Erjefält JS, Korsgren M, Malm-Erjefält M, et al., 2003, Acute allergic responses induce a prompt luminal entry of airway tissue eosinophils, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 29, Pages: 439-448, ISSN: 1044-1549
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- Citations: 12
Xanthou G, Williams TJ, Pease JE, 2003, Molecular characterization of the chemokine receptor CXCR3: evidence for the involvement of distinct extracellular domains in a multi-step model of ligand binding and receptor activation, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 33, Pages: 2927-2936, ISSN: 0014-2980
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- Citations: 75
Conroy DM, Jopling LA, Lloyd CM, et al., 2003, CCR4 blockade does not inhibit allergic airways inflammation, JOURNAL OF LEUKOCYTE BIOLOGY, Vol: 74, Pages: 558-563, ISSN: 0741-5400
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- Citations: 48
Xanthou G, Duchesnes CE, Williams TJ, et al., 2003, CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 33, Pages: 2241-2250, ISSN: 0014-2980
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- Citations: 98
Phillips RM, Stubbs VEL, Henson MR, et al., 2003, Variations in eosinophil chemokine responses: An investigation of CCR1 and CCR3 function, expression in atopy, and identification of a functional CCR1 promoter, JOURNAL OF IMMUNOLOGY, Vol: 170, Pages: 6190-6201, ISSN: 0022-1767
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- Citations: 37
Culley FJ, Fadlon EJ, Kirchem A, et al., 2003, Proteoglycans are potent modulators of the biological responses of eosinophils to chemokines, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 33, Pages: 1302-1310, ISSN: 0014-2980
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- Citations: 36
Buckland KF, Williams TJ, Conroy DM, 2003, Histamine induces shape change and actin polymerisation in human eosinophils via the novel H<sub>4</sub> receptor, Meeting of the British-Pharmacological-Society-Clinical-Pharmacology-Section, Publisher: NATURE PUBLISHING GROUP, Pages: U22-U22, ISSN: 0007-1188
Larbi KY, Dangerfield JP, Culley FJ, et al., 2003, P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses, JOURNAL OF LEUKOCYTE BIOLOGY, Vol: 73, Pages: 65-73, ISSN: 0741-5400
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- Citations: 12
Pease JE, Weller CL, Williams TJ, 2003, Regulation of eosinophil trafficking in asthma and allergy, CHEMOKINE ROLES IN IMMUNOREGULATION AND DISEASE, Vol: 45, Pages: 85-100, ISSN: 0947-6075
Falcao PL, Correa-Oliveira R, Fraga LAO, et al., 2002, Plasma concentrations and role of macrophage inflammatory protein-1α during chronic <i>Schistosoma mansoni</i> infection in humans, JOURNAL OF INFECTIOUS DISEASES, Vol: 186, Pages: 1696-1700, ISSN: 0022-1899
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- Citations: 34
Menzies-Gow A, Ying S, Sabroe I, et al., 2002, Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers, JOURNAL OF IMMUNOLOGY, Vol: 169, Pages: 2712-2718, ISSN: 0022-1767
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- Citations: 188
Stubbs VEL, Schratl P, Hartnell A, et al., 2002, Indomethacin causes prostaglandin D<sub>2</sub>-like and eotaxin-like selective responses in eosinophils and basophils, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 277, Pages: 26012-26020
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- Citations: 71
Nouri-Aria KT, Wilson D, Francis JN, et al., 2002, CCR4 in human allergen-induced late responses in the skin and lung, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 32, Pages: 1933-1938, ISSN: 0014-2980
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- Citations: 54
Bryan SA, Jose PJ, Topping JR, et al., 2002, Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 165, Pages: 1602-1609, ISSN: 1073-449X
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- Citations: 50
Williams TJ, 2002, Stalking the chemokine, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 165, Pages: 1350-1351, ISSN: 1073-449X
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- Citations: 2
Culley FJ, Brown A, Girod N, et al., 2002, Innate and cognate mechanisms of pulmonary eosinophilia in helminth infection, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 32, Pages: 1376-1385, ISSN: 0014-2980
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- Citations: 21
Banwell ME, Tolley NS, Williams TJ, et al., 2002, Regulation of human eotaxin-3/CCL26 expression: Modulation by cytokines and glucocorticoids, CYTOKINE, Vol: 17, Pages: 317-323, ISSN: 1043-4666
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- Citations: 56
Jopling LA, Sabroe I, Andrew DP, et al., 2002, The identification, characterization, and distribution of guinea pig CCR4 and epitope mapping of a blocking antibody, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 277, Pages: 6864-6873, ISSN: 0021-9258
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- Citations: 17
Sabroe I, Lloyd CM, Whyte MKB, et al., 2002, Chemokines, innate and adaptive immunity, and respiratory disease, EUROPEAN RESPIRATORY JOURNAL, Vol: 19, Pages: 350-355, ISSN: 0903-1936
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- Citations: 48
Pease J E, Williams TJ, 2002, Chemokines, Asthma and COPD, Editors: Barnes, Publisher: Academic Press, ISBN: 9780120790289
Erin EM, Williams TJ, Barnes PJ, et al., 2002, Eotaxin receptor (CCR3) antagonism in asthma and allergic disease, Curr Drug Targets - Inflammation & Allergy, Vol: 1, Pages: 201-214, ISSN: 1568-010X
Penido C, Castro-Faria-Neto HC, Vieira-de-Abreu A, et al., 2001, LPS induces eosinophil migration via CCR3 signaling through a mechanism independent of RANTES and eotaxin, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 25, Pages: 707-716, ISSN: 1044-1549
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- Citations: 42
Chadwick SL, Walker S, Muramaki K, et al., 2001, Basophil gated fluorescence/forward scatter (bGFS) assay for the investigation of IgE mediated allergic responses and its comparison to skin prick testing, THORAX, Vol: 56, Pages: 34-34, ISSN: 0040-6376
Martinelli R, Sabroe I, LaRosa G, et al., 2001, The CC chemokine eotaxin (CCL11) is a partial agonist of CC chemokine receptor 2b, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 276, Pages: 42957-42964, ISSN: 0021-9258
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- Citations: 62
Au BT, Teixeira MM, Collins PD, et al., 2001, Blockade of PAF receptors controls interleukin-8 production by regulating the activation of neutrophil CD11/CD18, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 425, Pages: 65-71, ISSN: 0014-2999
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- Citations: 11
Pease JE, Williams TJ, 2001, Eotaxin and asthma., Curr Opin Pharmacol, Vol: 1, Pages: 248-253, ISSN: 1471-4892
Eotaxin is a small protein that is produced in the lungs of asthmatic patients and is a potent chemoattractant for eosinophils. Eotaxin, a CC chemokine, stimulates the migration of eosinophils from the small blood vessels in the lungs by acting on the CC chemokine receptor CCR3, which is located on the leukocyte cell surface. In the past year, three low molecular weight compounds have been developed that can block this receptor. Such compounds may be developed into orally available drugs aimed at preventing eosinophil recruitment and, hence, the pathogenesis associated with the activation of these cells within the lung tissue.
Sabroe I, Williams TJ, Pease JE, 2001, Roles of chemokines in the regulation of leucocyte recruitment, CLINICAL SCIENCE, Vol: 100, Pages: 359-362, ISSN: 0143-5221
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- Citations: 4
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