Imperial College London
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ProfessorTimothyHallett

Faculty of Medicine, School of Public Health

Professor of Global Health
 
 
 
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Contact

 

+44 (0)20 7594 1150timothy.hallett

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Toor:2021:10.7554/eLife.67635,
author = {Toor, J and Echeverria-Londono, S and Li, X and Abbas, K and Carter, ED and Clapham, HE and Clark, A and de, Villiers MJ and Eilertson, K and Ferrari, M and Gamkrelidze, I and Hallett, TB and Hinsley, WR and Hogan, D and Huber, JH and Jackson, ML and Jean, K and Jit, M and Karachaliou, A and Klepac, P and Kraay, A and Lessler, J and Li, X and Lopman, BA and Mengistu, T and Metcalf, CJE and Moore, SM and Nayagam, S and Papadopoulos, T and Perkins, TA and Portnoy, A and Razavi, H and Razavi-Shearer, D and Resch, S and Sanderson, C and Sweet, S and Tam, Y and Tanvir, H and Tran, Minh Q and Trotter, CL and Truelove, SA and Vynnycky, E and Walker, N and Winter, A and Woodruff, K and Ferguson, NM and Gaythorpe, KA},
doi = {10.7554/eLife.67635},
journal = {eLife},
title = {Lives saved with vaccination for 10 pathogens across 112 countries in a pre-COVID-19 world},
url = {http://dx.doi.org/10.7554/eLife.67635},
volume = {10},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Vaccination is one of the most effective public health interventions. We investigate the impact of vaccination activities for Haemophilus influenzae type b, hepatitis B, human papillomavirus, Japanese encephalitis, measles, Neisseria meningitidis serogroup A, rotavirus, rubella, Streptococcus pneumoniae, and yellow fever over the years 2000-2030 across 112 countries. Methods: Twenty-one mathematical models estimated disease burden using standardised demographic and immunisation data. Impact was attributed to the year of vaccination through vaccine-activity-stratified impact ratios. Results: We estimate 97 (95%CrI[80, 120]) million deaths would be averted due to vaccination activities over 2000-2030, with 50 (95%CrI[41, 62]) million deaths averted by activities between 2000 and 2019. For children under-5 born between 2000 and 2030, we estimate 52 (95%CrI[41, 69]) million more deaths would occur over their lifetimes without vaccination against these diseases. Conclusions: This study represents the largest assessment of vaccine impact before COVID-19-related disruptions and provides motivation for sustaining and improving global vaccination coverage in the future. Funding: VIMC is jointly funded by Gavi, the Vaccine Alliance, and the Bill and Melinda Gates Foundation (BMGF) (BMGF grant number: OPP1157270 / INV-009125). Funding from Gavi is channelled via VIMC to the Consortium's modelling groups (VIMC-funded institutions represented in this paper: Imperial College London, London School of Hygiene and Tropical Medicine, Oxford University Clinical Research Unit, Public Health England, Johns Hopkins University, The Pennsylvania State University, Center for Disease Analysis Foundation, Kaiser Permanente Washington, University of Cambridge, University of Notre Dame, Harvard University, Conservatoire National des Arts et Métiers, Emory University, National University of Singapore). Funding from BMGF was used for salaries of the Consortium secretariat (auth
AU  - Toor,J
AU  - Echeverria-Londono,S
AU  - Li,X
AU  - Abbas,K
AU  - Carter,ED
AU  - Clapham,HE
AU  - Clark,A
AU  - de,Villiers MJ
AU  - Eilertson,K
AU  - Ferrari,M
AU  - Gamkrelidze,I
AU  - Hallett,TB
AU  - Hinsley,WR
AU  - Hogan,D
AU  - Huber,JH
AU  - Jackson,ML
AU  - Jean,K
AU  - Jit,M
AU  - Karachaliou,A
AU  - Klepac,P
AU  - Kraay,A
AU  - Lessler,J
AU  - Li,X
AU  - Lopman,BA
AU  - Mengistu,T
AU  - Metcalf,CJE
AU  - Moore,SM
AU  - Nayagam,S
AU  - Papadopoulos,T
AU  - Perkins,TA
AU  - Portnoy,A
AU  - Razavi,H
AU  - Razavi-Shearer,D
AU  - Resch,S
AU  - Sanderson,C
AU  - Sweet,S
AU  - Tam,Y
AU  - Tanvir,H
AU  - Tran,Minh Q
AU  - Trotter,CL
AU  - Truelove,SA
AU  - Vynnycky,E
AU  - Walker,N
AU  - Winter,A
AU  - Woodruff,K
AU  - Ferguson,NM
AU  - Gaythorpe,KA
DO  - 10.7554/eLife.67635
PY  - 2021///
SN  - 2050-084X
TI  - Lives saved with vaccination for 10 pathogens across 112 countries in a pre-COVID-19 world
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.67635
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34253291
UR  - http://hdl.handle.net/10044/1/90441
VL  - 10
ER  -
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