I am a Lecturer in Environmental Toxicology & Biomarkers in the Department of Metabolism, Digestion, and Reproduction. My main research interests are in the application of molecular profiling technologies – primarily metabolic profiling using NMR and MS based platforms – to study aspects of human health and disease. A key research question of importance is how to improve exposure assessment in individuals, small area studies and molecular epidemiology projects investigating environmental exposures. I am also interested in addressing the need for a more comprehensive understanding of the toxicological implications of emerging materials such as nanoparticles. At present, a number of large-scale projects focused on developing the concept of the exposome are underway, and present new opportunities for metabolic research to help understand links between environmental exposures and human health outcomes.
I studied for a PhD in biological chemistry at Imperial College London, which was awarded in 2007. My thesis, "Analytical and chemometric investigations of congeneric substituted aniline metabolism" focused on investigating the metabolic fate of a number of substituted anilines in vivo using NMR, MS and UPLC. These studies are part of ongoing efforts to develop predictive models of xenobiotic metabolism.
I studied as an undergraduate at Exeter University in the Department of Chemistry. I was awarded a first-class honours degree in Biological and Medicinal Chemistry upon graduating in 2002
et al., 2020, Simultaner enantiospezifischer Nachweis mehrerer Verbindungen in Mischungen mittels NMR‐Spektroskopie, Angewandte Chemie, Vol:132, ISSN:0044-8249, Pages:23821-23826
et al., 2020, Simultaneous enantiospecific detection of multiple compounds in mixtures using NMR spectroscopy., Angewandte Chemie International Edition, Vol:59, ISSN:1433-7851, Pages:23615-23619
et al., 2020, Acyl glucuronide reactivity in perspective, Drug Discovery Today, Vol:25, ISSN:1359-6446, Pages:1639-1650
et al., 2020, Brake dust exposure exacerbates inflammation and transiently compromises phagocytosis in macrophages, Metallomics: Integrated Biometal Science, Vol:12, ISSN:1756-5901, Pages:371-386
et al., 2020, Kinetic modelling of acyl glucuronide and glucoside reactivity and development of structure-property relationships, Organic and Biomolecular Chemistry, Vol:18, ISSN:1477-0520, Pages:1389-1401