Publications
353 results found
Maitland K, Nadel S, Pollard AJ, et al., 2005, Management of severe malaria in children: proposed guidelines for the United Kingdom, British Medical Journal, Vol: 331, Pages: 337-343, ISSN: 0959-8146
Williams TN, Wambua S, Uyoga S, et al., 2005, Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya, Blood, Vol: 106, Pages: 368-371, ISSN: 0006-4971
Williams TN, Mwangi TW, Roberts DJ, et al., 2005, An immune basis for malaria protection by the sickle cell trait, PLoS Medicine, Vol: 2, Pages: 0441-0445, ISSN: 1549-1277
BackgroundMalaria resistance by the sickle cell trait (genotype HbAS) has served as the prime example of genetic selection for over half a century. Nevertheless, the mechanism of this resistance remains the subject of considerable debate. While it probably involves innate factors such as the reduced ability of Plasmodium falciparum parasites to grow and multiply in HbAS erythrocytes, recent observations suggest that it might also involve the accelerated acquisition of malaria-specific immunity.Methods and FindingsWe studied the age-specific protection afforded by HbAS against clinical malaria in children living on the coast of Kenya. We found that protection increased with age from only 20% in the first 2 y of life to a maximum of 56% by the age of 10 y, returning thereafter to 30% in participants greater than 10 y old.ConclusionsOur observations suggest that malaria protection by HbAS involves the enhancement of not only innate but also of acquired immunity to the parasite. A better understanding of the underlying mechanisms might yield important insights into both these processes.
Nyakeriga AM, Troye-Blomberg M, Mwacharo JK, et al., 2005, Nutritional iron status in children with α<SUP>+</SUP> thalassemia and the sickle cell trait in a malaria endemic area on the coast of Kenya, HAEMATOLOGICA, Vol: 90, Pages: 552-554, ISSN: 0390-6078
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- Citations: 8
Dorfman JR, Bejon P, Ndung u FM, et al., 2005, B cell memory to three P. falciparum blood stage antigens in an endemic area, Pages: A937-A937, ISSN: 0892-6638
Berkley JAG, 2005, Bacteremia among children admitted to a rural hospital in Kenya, New England Journal of Medicine, Vol: 352, Pages: 39-47
Eziefula A, Mwakisha N, Macharia A, et al., 2005, Correlates of red blood cell deformability (RCD) with adverse outcome in severe falciparum malaria: The effect of sequestered parasitized red cells [MIM-AE-70550], ACTA TROPICA, Vol: 95, Pages: S384-S385, ISSN: 0001-706X
Wambua S, Mwangi T, Uyoga S, et al., 2005, alpha plus Thalassaemia protects against malaria-induced anaemia in children living on the coast of Kenya [MIM-SW-139920], Pages: S486-S487, ISSN: 0001-706X
Nyakeriga A, Troye-blomberg M, Chemtai A, et al., 2005, Nutritional status and malaria infections in children in malaria endemic area of Kenyan coast [MIM-AN-251750], ACTA TROPICA, Vol: 95, Pages: S409-S409, ISSN: 0001-706X
Williams TN, Mwangi TW, Wambua S, et al., 2005, Negative epistasis between the malaria-protective effects of α+-thalassemia and the sickle cell trait, Nature Genetics, Vol: 37, Pages: 1253-1257
Williams TN, Mwangi TW, Wambua S, et al., 2005, Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases, Journal of Infectious Diseases, Vol: 192, Pages: 178-186
Mugyenyi C, Beeson J, Williams T, et al., 2005, Antibody acquisition against apical membrane antigen 1 in a cohort of children and the relationship to malaria exposure and protective immunity [MIM-CM-40691], Pages: S162-S162, ISSN: 0001-706X
Nyakeriga AM, Williams TN, Marsh K, et al., 2005, Cytokine mRNA expression and iron status in children living in a malaria endemic area, Scandinavian Journal of Immunology, Vol: 61, Pages: 370-375
Nyakeriga AM, Troye-Blomberg M, Mwacharo JK, et al., 2005, Nutritional iron status in children with α+thalassemia and the sickle cell trait in a malaria endemic area on the coast of Kenya, Haematologica, Vol: 90, Pages: 552-554
Makani J, Meda E, Rwezaula S, et al., 2005, The role of malaria infection in morbidity and mortality in sickle cell disease in east africa: Preliminary evidence from a cohort study [MIM-JM-1200], Pages: S90-S91, ISSN: 0001-706X
Williams T, Mwangi T, Wambua S, et al., 2005, Negative epistasis between the malaria-protective effects of alpha (+) thalassaemia and the sickle cell trait [MIM-TW-395505], ACTA TROPICA, Vol: 95, Pages: S91-S91, ISSN: 0001-706X
Urban B, Williams T, Bull P, et al., 2005, Peripheral blood dendritic cells in Kenyan children with acute falciparum malaria [MIM-BU-29088], ACTA TROPICA, Vol: 95, Pages: S114-S114, ISSN: 0001-706X
Nyakeriga AM, Troye-Blomberg M, Chemtai AK, et al., 2005, Erratum: Malaria and nutritional status in children living on the coast of Kenya (American Journal of Clinical Nutrition (2004) 80 (1604-1610)), American Journal of Clinical Nutrition, Vol: 82
Dorfman JR, Bejon P, Ndungu FM, et al., 2005, B cell memory to 3 Plasmodium falciparum blood-stage antigens in a malaria-endemic area, Journal of Infectious Diseases, Vol: 191, Pages: 1623-1630
Kinyanjui SM, Howard T, Williams TN, et al., 2004, The use of cryopreserved mature trophozoites in assessing antibody recognition of variant surface antigens of Plasmodium falciparum-infected erythrocytes, Journal of Immunological Methods, Vol: 288, Pages: 9-18
Nyakeriga AM, Troye-Blomberg M, Dorfman JR, et al., 2004, Iron deficiency and malaria among children living on the coast of Kenya, Journal of Infectious Diseases, Vol: 190, Pages: 439-447
Maitland TN, 2004, Falciparum malaria: Current therapeutic challenges, Current Opinion in Infectious Diseases, Vol: 17, Pages: 405-412
Polley SD, Mwangi T, Kocken CHM, et al., 2004, Human antibodies to recombinant protein constructs of Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) and their associations with protection from malaria, Vaccine, Vol: 23, Pages: 718-728
Maitland TN, 2004, HLA class-I and class-II allele frequencies and two-locus haplotypes in Melanesians of Vanuatu and New Caledonia, Tissue Antigens, Vol: 64, Pages: 678-686
Nyakeriga AM, Troye-Blomberg M, Chemtai AK, et al., 2004, Malaria and nutritional status in children living on the coast of Kenya, American Journal of Clinical Nutrition, Vol: 80, Pages: 1604-1610
Williams TN, Newbold CI, 2003, Reevaluation of Flow Cytometry for Investigating Antibody Binding to the Surface of Plasmodium falciparum Trophozoite-Infected Red Blood Cells, Cytometry Part A, Vol: 56, Pages: 96-103
Roberts DJ, Williams TN, 2003, Haemoglobinopathies and resistance to malaria, Pages: 304-310
Goodman K, 2003, Ciguatera poisoning in Vanuatu, American Journal of Tropical Medicine and Hygiene, Vol: 68, Pages: 263-266
Williams TN, Weatherall DJ, Newbold CI, 2002, The membrane characteristics of Plasmodium falciparum-infected and -uninfected heterozygous α0thalassaemic erythrocytes, British Journal of Haematology, Vol: 118, Pages: 663-670
Maitland CI, 2000, Genetic restriction of Plasmodium falciparum in an area of stable transmission: An example of island evolution?, Parasitology, Vol: 120, Pages: 335-343
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