Publications
353 results found
Hodgson SH, Juma E, Salim A, et al., 2014, Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection, Frontiers in Microbiology, Vol: 5
Opi DH, Ochola LB, Tendwa M, et al., 2014, Mechanistic studies of the negative epistatic malaria-protective interaction between sickle cell trait and α+thalassemia, EBioMedicine, Vol: 1, Pages: 29-36
Lee JC, Espéli M, Anderson CA, et al., 2013, Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway, Cell, Vol: 155, Pages: 57-69, ISSN: 0092-8674
The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically determines the impact a disease has on a patient’s life but is very poorly understood. Here, we exploit existing genome-wide association study data to gain insight into the role of genetics in prognosis. We identify a noncoding polymorphism in FOXO3A (rs12212067: T > G) at which the minor (G) allele, despite not being associated with disease susceptibility, is associated with a milder course of Crohn’s disease and rheumatoid arthritis and with increased risk of severe malaria. Minor allele carriage is shown to limit inflammatory responses in monocytes via a FOXO3-driven pathway, which through TGFβ1 reduces production of proinflammatory cytokines, including TNFα, and increases production of anti-inflammatory cytokines, including IL-10. Thus, we uncover a shared genetic contribution to prognosis in distinct diseases that operates via a FOXO3-driven pathway modulating inflammatory responses.
Piel FB, Patil AP, Howes RE, et al., 2013, Global epidemiology of Sickle haemoglobin in neonates: A contemporary geostatistical model-based map and population estimates, The Lancet, Vol: 381, Pages: 142-151, ISSN: 0140-6736
Amendah DD, Mukamah G, Komba A, et al., 2013, Routine Paediatric Sickle Cell Disease (SCD) Outpatient Care in a Rural Kenyan Hospital: Utilization and Costs, PLoS ONE, Vol: 8
Foote EM, Sullivan KM, Ruth LJ, et al., 2013, Determinants of anemia among preschool children in rural, western Kenya, American Journal of Tropical Medicine and Hygiene, Vol: 88, Pages: 757-764
Marsh V, Mocamah G, Mabibo E, et al., 2013, The "Difficult Patient" Conundrum in Sickle Cell Disease in Kenya: Complex Sociopolitical Problems Need Wide Multidimensional Solutions, American Journal of Bioethics, Vol: 13, Pages: 20-22
Piel FB, Howes RE, Patil AP, et al., 2013, The distribution of haemoglobin C and its prevalence in newborns in Africa, Scientific Reports, Vol: 3
Piel FB, Hay SI, Gupta S, et al., 2013, Global Burden of Sickle Cell Anaemia in Children under Five, 2010-2050: Modelling Based on Demographics, Excess Mortality, and Interventions, PLoS Medicine, Vol: 10
Howes RE, Dewi M, Piel FB, et al., 2013, Spatial distribution of G6PD deficiency variants across malaria-endemic regions, Malaria Journal, Vol: 12
Marsh V, Kombe F, Fitzpatrick R, et al., 2013, Consulting communities on feedback of genetic findings in international health research: Sharing sickle cell disease and carrier information in coastal Kenya, BMC Medical Ethics, Vol: 14
Kariuki SM, Rockett K, Clark TG, et al., 2013, The genetic risk of acute seizures in African children with falciparum malaria, Epilepsia, Vol: 54, Pages: 990-1001
Band G, Le QS, Jostins L, et al., 2013, Imputation-Based Meta-Analysis of Severe Malaria in Three African Populations, PLoS Genetics, Vol: 9
Piel FB, Howes RE, Nyangiri OA, et al., 2013, Online Biomedical Resources for Malaria-Related Red Cell Disorders, Human Mutation, Vol: 34, Pages: 937-944
Uyoga S, Skorokhod OA, Opiyo M, et al., 2012, Transfer of 4-hydroxynonenal from parasitized to non-parasitized erythrocytes in rosettes. Proposed role in severe malaria anemia, British Journal of Haematology, Vol: 157, Pages: 116-124
Williams TN, Weatherall DJ, 2012, World distribution, population genetics, and health burden of the hemoglobinopathies, Cold Spring Harbor Perspectives in Biology, Vol: 4
de Vries J, Jallow M, Williams TN, et al., 2012, Investigating the potential for ethnic group harm in collaborative genomics research in Africa: Is ethnic stigmatisation likely?, Social Science and Medicine, Vol: 75, Pages: 1400-1407
Uyoga S, Skorokhod OA, Opiyo M, et al., 2012, research paper, British Journal of Haematology, ISSN: 0007-1048
Scott JAG, Bauni E, Moisi JC, et al., 2012, Profile: The Kilifi health and demographic surveillance system (KHDSS), International Journal of Epidemiology, Vol: 41, Pages: 650-657
Grosse SD, Atrash HK, Odame I, et al., 2012, The Jamaican historical experience of the impact of educational interventions on sickle cell disease child mortality, American Journal of Preventive Medicine, Vol: 42, Pages: e101-e103
Williams TN, Weatherall DJ, 2012, World distribution, population genetics, and health burden of the hemoglobinopathies, Cold Spring Harbor Perspectives in Medicine, Vol: 2
Williams TN, 2012, Balancing act: Haemoglobinopathies and malaria, The Lancet Infectious Diseases, Vol: 12, Pages: 427-428
Williams T, 2011, Red blood cell polymorphisms and malaria, TROPICAL MEDICINE & INTERNATIONAL HEALTH, Vol: 16, Pages: 10-11, ISSN: 1360-2276
Williams T, 2011, Red cell genetic disorders: burden and selective pressures in Africa, Pages: S23-S23, ISSN: 0022-2593
Kariuki SM, Rockett K, Clark TG, et al., 2011, HUMAN GENETIC POLYMORPHISMS AND THE RISK OF MALARIA-ASSOCIATED SEIZURES IN AFRICAN POPULATIONS, Pages: 92-92, ISSN: 0013-9580
Cox SE, Makani J, Soka D, et al., 2011, Nutritional status, hospitalization and mortality among patients with sickle cell anaemia in Tanzania, Experimental Biology Meeting 2011, Publisher: FEDERATION AMER SOC EXP BIOL, ISSN: 0892-6638
Scott JAG, Berkley JA, Mwangi I, et al., 2011, Relation between falciparum malaria and bacteraemia in Kenyan children: A population-based, case-control study and a longitudinal study, The Lancet, Vol: 378, Pages: 1316-1323, ISSN: 0140-6736
Williams TN, 2011, How do hemoglobins S and C result in malaria protection?, Journal of Infectious Diseases, Vol: 204, Pages: 1651-1653
Grosse SD, Odame I, Atrash HK, et al., 2011, Sickle cell disease in Africa: A neglected cause of early childhood mortality, American Journal of Preventive Medicine, Vol: 41, Pages: S398-S405
Cox SE, Makani J, Fulford AJ, et al., 2011, Nutritional status, hospitalization and mortality among patients with sickle cell anemia in Tanzania, Pages: 948-953
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