Imperial College London
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Professor Thomas N Williams

Faculty of Medicine, Department of Surgery & Cancer

Chair in Haemoglobinopathy Research
 
 
 
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Contact

 

tom.williams Website

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Olupot-Olupot:2020:10.1186/s12936-020-03390-7,
author = {Olupot-Olupot, P and Engoru, C and Nteziyaremye, J and Chebet, M and Ssenyondo, T and Muhindo, R and Nyutu, G and Macharia, A and Uyoga, S and Ndila, CM and Karamagi, C and Maitland, K and Williams, T},
doi = {10.1186/s12936-020-03390-7},
journal = {Malaria Journal},
title = {The clinical spectrum of severe childhood malaria in Eastern Uganda},
url = {http://dx.doi.org/10.1186/s12936-020-03390-7},
volume = {19},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundFew recent descriptions of severe childhood malaria have been published from high-transmission regions. In the current study, the clinical epidemiology of severe malaria in Mbale, Eastern Uganda, is described, where the entomological inoculation rate exceeds 100 infective bites per year.MethodsA prospective descriptive study was conducted to determine the prevalence, clinical spectrum and outcome of severe Plasmodium falciparum malaria at Mbale Regional Referral Hospital in Eastern Uganda. All children aged 2 months–12 years who presented on Mondays to Fridays between 8.00 am and 5.00 pm from 5th May 2011 until 30th April 2012 were screened for parasitaemia. Clinical and laboratory data were then collected from all P. falciparum positive children with features of WHO-defined severe malaria by use of a standardized proforma.ResultsA total of 10 208 children were screened of which 6582 (64%) had a positive blood film. Of these children, 662 (10%) had clinical features of severe malaria and were consented for the current study. Respiratory distress was the most common severity feature (554; 83.7%), while 365/585 (62.4%) had hyperparasitaemia, 177/662 (26.7%) had clinical jaundice, 169 (25.5%) had severe anaemia, 134/660 (20.2%) had hyperlactataemia (lactate ≥ 5 mmol/L), 93 (14.0%) had passed dark red or black urine, 52 (7.9%) had impaired consciousness and 49/662 (7.4%) had hypoxaemia (oxygen saturations < 90%). In-hospital mortality was 63/662 (9.5%) overall but was higher in children with either cerebral malaria (33.3%) or severe anaemia (19.5%). Factors that were independently associated with mortality on multivariate analysis included severe anaemia [odds ratio (OR) 5.36; 2.16–1.32; P = 0.0002], hyperlactataemia (OR 3.66; 1.72–7.80; P = 0.001), hypoxaemia (OR) 3.64 (95% CI 1.39–9.52; P = 0.008), and hepatomegaly (OR 2.29; 1.29–4.06; P = 
AU  - Olupot-Olupot,P
AU  - Engoru,C
AU  - Nteziyaremye,J
AU  - Chebet,M
AU  - Ssenyondo,T
AU  - Muhindo,R
AU  - Nyutu,G
AU  - Macharia,A
AU  - Uyoga,S
AU  - Ndila,CM
AU  - Karamagi,C
AU  - Maitland,K
AU  - Williams,T
DO  - 10.1186/s12936-020-03390-7
PY  - 2020///
SN  - 1475-2875
TI  - The clinical spectrum of severe childhood malaria in Eastern Uganda
T2  - Malaria Journal
UR  - http://dx.doi.org/10.1186/s12936-020-03390-7
UR  - http://hdl.handle.net/10044/1/82528
VL  - 19
ER  -
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