Imperial College London
Portrait Picture

Professor Thomas N Williams

Faculty of Medicine, Department of Surgery & Cancer

Chair in Haemoglobinopathy Research
 
 
 
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Contact

 

tom.williams Website

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Muriuki:2021:10.1038/s41591-021-01238-4,
author = {Muriuki, JM and Mentzer, AJ and Mitchell, R and Webb, EL and Etyang, AO and Kyobutungi, C and Morovat, A and Kimita, W and Ndungu, FM and Macharia, AW and Ngetsa, CJ and Makale, J and Lule, SA and Musani, SK and Raffield, LM and Cutland, CL and Sirima, SB and Diarra, A and Tiono, AB and Fried, M and Gwamaka, M and Adu-Afarwuah, S and Wirth, JP and Wegmueller, R and Madhi, SA and Snow, RW and Hill, AVS and Rockett, KA and Sandhu, MS and Kwiatkowski, DP and Prentice, AM and Byrd, KA and Ndjebayi, A and Stewart, CP and Engle-Stone, R and Green, TJ and Karakochuk, CD and Suchdev, PS and Bejon, P and Duffy, PE and Davey, Smith G and Elliott, AM and Williams, TN and Atkinson, SH},
doi = {10.1038/s41591-021-01238-4},
journal = {Nature Medicine},
pages = {653--658},
title = {Malaria is a cause of iron deficiency in African children},
url = {http://dx.doi.org/10.1038/s41591-021-01238-4},
volume = {27},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Malaria and iron deficiency (ID) are common and interrelated public health problems in African children. Observational data suggest that interrupting malaria transmission reduces the prevalence of ID1. To test the hypothesis that malaria might cause ID, we used sickle cell trait (HbAS, rs334), a genetic variant that confers specific protection against malaria2, as an instrumental variable in Mendelian randomization analyses. HbAS was associated with a 30% reduction in ID among children living in malaria-endemic countries in Africa (n = 7,453), but not among individuals living in malaria-free areas (n = 3,818). Genetically predicted malaria risk was associated with an odds ratio of 2.65 for ID per unit increase in the log incidence rate of malaria. This suggests that an intervention that halves the risk of malaria episodes would reduce the prevalence of ID in African children by 49%.
AU  - Muriuki,JM
AU  - Mentzer,AJ
AU  - Mitchell,R
AU  - Webb,EL
AU  - Etyang,AO
AU  - Kyobutungi,C
AU  - Morovat,A
AU  - Kimita,W
AU  - Ndungu,FM
AU  - Macharia,AW
AU  - Ngetsa,CJ
AU  - Makale,J
AU  - Lule,SA
AU  - Musani,SK
AU  - Raffield,LM
AU  - Cutland,CL
AU  - Sirima,SB
AU  - Diarra,A
AU  - Tiono,AB
AU  - Fried,M
AU  - Gwamaka,M
AU  - Adu-Afarwuah,S
AU  - Wirth,JP
AU  - Wegmueller,R
AU  - Madhi,SA
AU  - Snow,RW
AU  - Hill,AVS
AU  - Rockett,KA
AU  - Sandhu,MS
AU  - Kwiatkowski,DP
AU  - Prentice,AM
AU  - Byrd,KA
AU  - Ndjebayi,A
AU  - Stewart,CP
AU  - Engle-Stone,R
AU  - Green,TJ
AU  - Karakochuk,CD
AU  - Suchdev,PS
AU  - Bejon,P
AU  - Duffy,PE
AU  - Davey,Smith G
AU  - Elliott,AM
AU  - Williams,TN
AU  - Atkinson,SH
DO  - 10.1038/s41591-021-01238-4
EP  - 658
PY  - 2021///
SN  - 1078-8956
SP  - 653
TI  - Malaria is a cause of iron deficiency in African children
T2  - Nature Medicine
UR  - http://dx.doi.org/10.1038/s41591-021-01238-4
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000620458400003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41591-021-01238-4
UR  - http://hdl.handle.net/10044/1/86430
VL  - 27
ER  -
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