Imperial College London

Tom Wong

Faculty of MedicineNational Heart & Lung Institute

Reader in Cardiology
 
 
 
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Contact

 

+44 (0)20 7351 8619tom.wong

 
 
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Assistant

 

Dr Vias Markides +44 (0)20 7351 8619

 
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Location

 

Chelsea WingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

182 results found

Riad OHMA, Wong T, Ali AN, Ibrahim MT, Abdelhamid MA, Nabih MAet al., 2023, Safety and outcome of cryoballoon ablation versus radiofrequency catheter ablation of the pulmonary veins in patients with paroxysmal atrial fibrillation (vol 113, hcaa041.027, 2020), QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 116, Pages: 732-732, ISSN: 1460-2725

Journal article

O'Connor M, Barbero U, Kramer DB, Lee A, Hua A, Ismail T, Mccarthy KP, Niederer S, Rinaldi CA, Markides V, Clarke J-RD, Babu-Narayan S, Ho SY, Wong Tet al., 2023, Anatomic, histologic, and mechanical features of the right atrium: implications for leadless atrial pacemaker implantation, EUROPACE, Vol: 25, ISSN: 1099-5129

Journal article

Khan HR, Yakupoglu HY, Kralj-Hans I, Haldar S, Bahrami T, Clague J, De Souza A, Hussain W, Jarman J, Jones DG, Salukhe T, Markides V, Gupta D, Khattar R, Wong T, CASA AFIet al., 2023, Left Atrial Function Predicts Atrial Arrhythmia Recurrence Following Ablation of Long-Standing Persistent Atrial Fibrillation, CIRCULATION-CARDIOVASCULAR IMAGING, Vol: 16, ISSN: 1941-9651

Journal article

Butcher CJT, Cantor E, Sohaib A, Shun-Shin MJ, Haynes R, Khan H, Kyriacou A, Shi R, Chen Z, Haldar S, Cleland JGF, Hussain W, Markides V, Jones DG, Lane RE, Mason MJ, Whinnett ZI, Francis DP, Wong Tet al., 2023, Variation in optimal hemodynamic atrio-ventricular delay of biventricular pacing with different endocardial left ventricular lead locations using precision hemodynamics, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 34, Pages: 1431-1440, ISSN: 1045-3873

Journal article

Betts TR, Good WW, Melki L, Metzner A, Grace A, Verma A, Murray S, James S, Wong T, Boersma LVA, Steven D, Sultan A, Busch S, Neuzil P, de Asmundis C, Lee J, Szili-Torok Tet al., 2023, Treatment of pathophysiologic propagation outside of the pulmonary veins in retreatment of atrial fibrillation patients: RECOVER AF study, EUROPACE, ISSN: 1099-5129

Journal article

Moore JP, de Groot NMS, Connor M, Cortez D, Su J, Burrows A, Shannon KM, Leary ETO, Shah M, Khairy P, Atallah J, Wong T, Lloyd MS, Taverne YJHJ, Dubin AM, Nielsen JC, Evertz R, Czosek RJ, Madhavan M, Chang PM, Aydin A, Cano Oet al., 2023, Conduction System Pacing Versus Conventional Cardiac Resynchronization Therapy in Congenital Heart Disease, JACC-CLINICAL ELECTROPHYSIOLOGY, Vol: 9, Pages: 385-393, ISSN: 2405-500X

Journal article

O'Connor M, Riad O, Shi R, Hunnybun D, Li W, Jarman JWE, Foran J, Rinaldi CA, Markides V, Gatzoulis MA, Wong Tet al., 2023, Left bundle branch area pacing in congenital heart disease, EUROPACE, Vol: 25, Pages: 561-570, ISSN: 1099-5129

Journal article

Elliott MK, Strocchi M, Sieniewicz BJ, Sidhu B, Mehta V, Wijesuriya N, Behar JM, Thorpe A, Martic D, Wong T, Niederer S, Rinaldi CAet al., 2023, Biventricular endocardial pacing and left bundle branch area pacing for cardiac resynchronization: Mechanistic insights from electrocardiographic imaging, acute hemodynamic response, and magnetic resonance imaging, HEART RHYTHM, Vol: 20, Pages: 207-216, ISSN: 1547-5271

Journal article

O'Connor M, Shi R, Kramer DB, Riad O, Hunnybun D, Jarman JWE, Foran J, Cantor E, Markides V, Wong Tet al., 2023, Conduction system pacing learning curve: Left bundle pacing compared to His bundle pacing, IJC HEART & VASCULATURE, Vol: 44

Journal article

Zakeri R, Ahluwalia N, Tindale A, Omar F, Packer M, Khan H, Baker V, Honarbakhsh S, Earley MJ, Sporton S, Schilling RJ, Jones D, Markides V, Hunter RJ, Wong Tet al., 2023, Long-term outcomes following catheter ablation versus medical therapy in patients with persistent atrial fibrillation and heart failure with reduced ejection fraction, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 25, Pages: 77-86, ISSN: 1388-9842

Journal article

Malaczynska-Rajpold K, Jarman J, Shi R, Wright P, Wong T, Markides Vet al., 2022, Beyond pulmonary vein isolation for persistent atrial fibrillation: sequential high-resolution mapping to guide ablation, JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY, Vol: 65, Pages: 53-62, ISSN: 1383-875X

Journal article

Bodagh N, Malaczynska-Rajpold K, Eysenck W, O'Connor M, Wong Tet al., 2022, Left Bundle Area Pacing for Tachycardia-Bradycardia Syndrome in a Patient With Dextrocardia., JACC Case Rep, Vol: 4, Pages: 1213-1217

We present the case of an 81-year-old woman with a background of situs inversus with dextrocardia who was successfully treated for tachycardia-bradycardia syndrome with left bundle area pacing. This report describes how this approach can circumvent the limitations of other pacing approaches to optimize patient outcomes. (Level of Difficulty: Intermediate.).

Journal article

Ladouceur M, Van De Bruaene A, Kauling R, Budts W, Roos-Hesselink J, Villagra Albert S, Sanchez Perez I, Sarubbi B, Fusco F, Gallego P, Rodriguez-Puras M-J, Bouchardy J, Blanche C, Rutz T, Prokselj K, Labombarda F, Iserin L, Wong T, Gatzoulis MAet al., 2022, A new score for life-threatening ventricular arrhythmias and sudden cardiac death in adults with transposition of the great arteries and a systemic right ventricle, EUROPEAN HEART JOURNAL, Vol: 43, Pages: 2685-+, ISSN: 0195-668X

Journal article

Schleberger R, Schwarzl JM, Moser J, Nies M, Hoeller A, Muenkler P, Dinshaw L, Jungen C, Lemoine MD, Maury P, Sacher F, Martin CA, Wong T, Estner HL, Jais P, Willems S, Eickholt C, Meyer Cet al., 2022, The impact of ultra-high-density mapping on long-term outcome after catheter ablation of ventricular tachycardia, SCIENTIFIC REPORTS, Vol: 12, ISSN: 2045-2322

Journal article

Mehta VS, O'Brien H, Elliott MK, Wijesuriya N, Auricchio A, Ayis S, Blomstrom-Lundqvist C, Bongiorni MG, Butter C, Deharo J-C, Gould J, Kennergren C, Kuck K-H, Kutarski A, Leclercq C, Maggioni AP, Sidhu BS, Wong T, Niederer S, Rinaldi CAet al., 2022, Machine learning-derived major adverse event prediction of patients undergoing transvenous lead extraction: Using the ESC EHRA EORP European lead extraction ConTRolled ELECTRa registry, HEART RHYTHM, Vol: 19, Pages: 885-893, ISSN: 1547-5271

Journal article

Griffiths S, Behar JM, Kramer DB, Debney MT, Monkhouse C, Lefas AY, Lowe M, Amin F, Cantor E, Boyalla V, Karim N, Till J, Markides V, Clague JR, Wong Tet al., 2022, The long-term outcomes of cardiac implantable electronic devices implanted via the femoral route, Pacing and Clinical Electrophysiology, Vol: 45, Pages: 481-490, ISSN: 0147-8389

BACKGROUND: Conventional superior access for cardiac implantable electronic devices (CIEDs) is not always possible and femoral CIEDs (F-CIED) are an alternative option when leadless systems are not suitable. The long-term outcomes and extraction experiences with F-CIEDs, in particular complex F-CIED (ICD/CRT devices), remain poorly understood. METHODS: Patients referred for F-CIEDs implantation between 2002 and 2019 at two tertiary centers were included. Early complications were defined as ≤30 days following implant and late complications >30 days. RESULTS: Thirty-one patients (66% male; age 56 ± 20 years; 35% [11] patients with congenital heart disease) were implanted with F-CIEDs (10 ICD/CRT and 21 pacemakers). Early complications were observed in 6.5% of patients: two lead displacements. Late complications at 6.8 ± 4.4 years occurred in 29.0% of patients. This was higher with complex F-CIED compared to simple F-CIED (60.0% vs. 14.3%, p = .02). Late complications were predominantly generator site related (n = 8, 25.8%) including seven infections/erosions and one generator migration. Eight femoral generators and 14 leads (median duration in situ seven [range 6-11] years) were extracted without complication. CONCLUSIONS: Procedural success with F-CIEDs is high with clinically acceptable early complication rates. There is a notable risk of late complications, particularly involving the generator site of complex devices following repeat femoral procedures. Extraction of chronic F-CIED in experienced centers is feasible and safe.

Journal article

O'Connor M, Ho SY, McCarthy KP, Gatzoulis M, Wong Tet al., 2022, Left bundle pacing in transposition of the great arteries with previous atrial redirection operation, HeartRhythm Case Reports, Vol: 8, Pages: 176-179, ISSN: 2214-0271

Journal article

Jun C, Zhang H, Mohiaddin R, Wong T, Firmin D, Keegan J, Yang Get al., 2022, Adaptive hierarchical dual consistency for semi-supervised left atrium segmentation on cross-domain data, IEEE Transactions on Medical Imaging, Vol: 41, Pages: 420-433, ISSN: 0278-0062

Semi-supervised learning provides great significance in left atrium (LA) segmentation model learning with insufficient labelled data. Generalising semi supervised learning to cross-domain data is of high importance to further improve model robustness. However, the widely existing distribution difference and sample mismatch between different data domains hinder the generalisation of semi-supervised learning. In this study, we alleviate these problems by proposing an Adaptive Hier10 archical Dual Consistency (AHDC) for the semi-supervised LA segmentation on cross-domain data. The AHDC mainlyconsists of a Bidirectional Adversarial Inference module (BAI) and a Hierarchical Dual Consistency learning module (HDC). The BAI overcomes the difference of distributions and the sample mismatch between two different domains. It mainly learns two mapping networks adversarially to obtain two matched domains through mutual adaptation. The HDC investigates a hierarchical dual learning paradigm for cross-domain semi-supervised segmentation based on the obtained matched domains. It mainly builds two dual modelling networks for mining the complementary information in both intra-domain and inter-domain. For the intra domain learning, a consistency constraint is applied to the dual-modelling targets to exploit the complementary modelling information. For the inter-domain learning, a consistency constraint is applied to the LAs modelled by two dual modelling networks to exploit the complementary knowl28 edge among different data domains. We demonstrated the performance of our proposed AHDC on four 3D late gadolinium enhancement cardiac MR (LGE-CMR) datasets fromdifferent centres and a 3D CT dataset. Compared to otherstate-of-the-art methods, our proposed AHDC achievedhigher segmentation accuracy, which indicated its capability in the cross-domain semi-supervised LA segmentation.

Journal article

Boyalla V, Harling L, Snell A, Kralj-Hans I, Barradas-Pires A, Haldar S, Khan HR, Cleland JGF, Athanasiou T, Harding SE, Wong Tet al., 2022, Biomarkers as predictors of recurrence of atrial fibrillation post ablation: an updated and expanded systematic review and meta-analysis, Clinical Research in Cardiology, Vol: 111, Pages: 680-691, ISSN: 0300-5860

BackgroundA high proportion of patients undergoing catheter ablation (CA) for atrial fibrillation (AF) experience recurrence of arrhythmia. This meta-analysis aims to identify pre-ablation serum biomarker(s) associated with arrhythmia recurrence to improve patient selection before CA.MethodsA systematic approach following PRISMA reporting guidelines was utilised in libraries (Pubmed/Medline, Embase, Web of Science, Scopus) and supplemented by scanning through bibliographies of articles. Biomarker levels were compared using a random-effects model and presented as odds ratio (OR). Heterogeneity was examined by meta-regression and subgroup analysis.ResultsIn total, 73 studies were identified after inclusion and exclusion criteria were applied. Nine out of 22 biomarkers showed association with recurrence of AF after CA. High levels of N-Terminal-pro-B-type-Natriuretic Peptide [OR (95% CI), 3.11 (1.80–5.36)], B-type Natriuretic Peptide [BNP, 2.91 (1.74–4.88)], high-sensitivity C-Reactive Protein [2.04 (1.28–3.23)], Carboxy-terminal telopeptide of collagen type I [1.89 (1.16–3.08)] and Interleukin-6 [1.83 (1.18–2.84)] were strongly associated with identifying patients with AF recurrence. Meta-regression highlighted that AF type had a significant impact on BNP levels (heterogeneity R2 = 55%). Subgroup analysis showed that high BNP levels were more strongly associated with AF recurrence in paroxysmal AF (PAF) cohorts compared to the addition of non-PAF patients. Egger’s test ruled out the presence of publication bias from small-study effects.ConclusionRanking biomarkers based on the strength of association with outcome provides each biomarker relative capacity to predict AF recurrence. This will provide randomised controlled trials, a guide to choosing a priori tool for identifying patients likely to revert to AF, which are required to substantiate these findings.

Journal article

Chen J, Yang G, Khan H, Zhang H, Zhang Y, Zhao S, Mohiaddin R, Wong T, Firmin D, Keegan Jet al., 2022, JAS-GAN: generative adversarial network based joint atrium and scar segmentations on unbalanced atrial targets, IEEE Journal of Biomedical and Health Informatics, Vol: 26, Pages: 103-114, ISSN: 2168-2194

Automated and accurate segmentation of the left atrium (LA) and atrial scars from late gadolinium-enhanced cardiac magnetic resonance (LGE CMR) images are in high demand for quantifying atrial scars. The previous quantification of atrial scars relies on a two-phase segmentation for LA and atrial scars due to their large volume difference (unbalanced atrial targets). In this paper, we propose an inter-cascade generative adversarial network, namely JAS-GAN, to segment the unbalanced atrial targets from LGE CMR images automatically and accurately in an end-to-end way. Firstly, JAS-GAN investigates an adaptive attention cascade to automatically correlate the segmentation tasks of the unbalanced atrial targets. The adaptive attention cascade mainly models the inclusion relationship of the two unbalanced atrial targets, where the estimated LA acts as the attention map to adaptively focus on the small atrial scars roughly. Then, an adversarial regularization is applied to the segmentation tasks of the unbalanced atrial targets for making a consistent optimization. It mainly forces the estimated joint distribution of LA and atrial scars to match the real ones. We evaluated the performance of our JAS-GAN on a 3D LGE CMR dataset with 192 scans. Compared with state-of-the-art methods, our proposed approach yielded better segmentation performance (Average Dice Similarity Coefficient (DSC) values of 0.946 and 0.821 for LA and atrial scars, respectively), which indicated the effectiveness of our proposed approach for segmenting unbalanced atrial targets.

Journal article

Shi R, Zaman JAB, Chen Z, Shi X, Zhu M, Sathishkumar A, Boyalla V, Karim N, Cantor E, Haldar S, Jones DG, Hussain W, Markides V, Virdee M, Wang X, Grace A, Wong Tet al., 2022, Novel aggregated multiposition noncontact mapping of atrial tachycardia in humans: From computational modeling to clinical validation, HEART RHYTHM, Vol: 19, Pages: 61-69, ISSN: 1547-5271

Journal article

O'Connor M, Gatzoulis M, Wong T, 2021, Conduction system pacing in adults with congenital heart disease, International Journal of Cardiology Congenital Heart Disease, Vol: 6, Pages: 100288-100288, ISSN: 2666-6685

Journal article

Haldar S, Khan HR, Boyalla V, Kralj-Hans I, Jones S, Lord J, Onyimadu O, Sathishkumar A, Bahrami T, Clague J, De Souza A, Francis D, Hussain W, Jarman J, Jones DG, Chen Z, Mediratta N, Hyde J, Lewis M, Mohiaddin R, Salukhe T, Murphy C, Kelly J, Khattar R, Toff WD, Markides V, McCready J, Gupta D, Wong Tet al., 2021, Thoracoscopic surgical ablation versus catheter ablation as first-line treatment for long-standing persistent atrial fibrillation: the CASA-AF RCT, Efficacy and Mechanism Evaluation, Vol: 8, Pages: 1-122, ISSN: 2050-4365

<jats:sec id="abs1-1"> <jats:title>Background</jats:title> <jats:p>Standalone thoracoscopic surgical ablation may be more effective than catheter ablation in patients with long-standing persistent atrial fibrillation.</jats:p> </jats:sec> <jats:sec id="abs1-2"> <jats:title>Objectives</jats:title> <jats:p>To determine whether or not surgical ablation is clinically superior to catheter ablation as the first-line treatment strategy in long-standing persistent atrial fibrillation.</jats:p> </jats:sec> <jats:sec id="abs1-3"> <jats:title>Design</jats:title> <jats:p>This was a prospective, multicentre, randomised control trial.</jats:p> </jats:sec> <jats:sec id="abs1-4"> <jats:title>Setting</jats:title> <jats:p>Four NHS tertiary centres in England.</jats:p> </jats:sec> <jats:sec id="abs1-5"> <jats:title>Participants</jats:title> <jats:p>Adults with long-standing persistent atrial fibrillation, who had European Heart Rhythm Association symptom scores &gt; 2 and who were naive to previous catheter ablation or thoracic/cardiac surgery.</jats:p> </jats:sec> <jats:sec id="abs1-6"> <jats:title>Interventions</jats:title> <jats:p>Minimally invasive thoracoscopic surgical ablation and conventional catheter ablation (control intervention).</jats:p> </jats:sec> <jats:sec id="abs1-7"> <jats:title>Mai

Journal article

Hind M, Wong T, 2021, Atrial Fibrillation, Obstructive Sleep Apnea, and Continuous Positive Airway Pressure: No Easy Fix, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 204, Pages: 503-505, ISSN: 1073-449X

Journal article

Gandjbakhch E, Laredo M, Berruezo A, Gourraud J-B, Sellal J-M, Martins R, Sacher F, Pison L, Pruvot E, Jauregui B, Frontera A, Kumar S, Wong T, DellaBella P, Maury Pet al., 2021, Outcomes after catheter ablation of ventricular tachycardia without implantable cardioverter-defibrillator in selected patients with arrhythmogenic right ventricular cardiomyopathy, EUROPACE, Vol: 23, Pages: 1428-1436, ISSN: 1099-5129

Journal article

Griffiths S, Behar JM, Li W, Kabir T, Wong Tet al., 2021, Cerebral protection device for transvenous lead extraction in a patient with an intracardiac shunt, International Journal of Cardiology Congenital Heart Disease, Vol: 4, Pages: 100138-100138, ISSN: 2666-6685

Journal article

Simard T, Jung RG, Lehenbauer K, Piayda K, Pracon R, Jackson GG, Flores-Umanzor E, Faroux L, Korsholm K, Chun JKR, Chen S, Maarse M, Montrella K, Chaker Z, Spoon JN, Pastormerlo LE, Meincke F, Sawant AC, Moldovan CM, Qintar M, Aktas MK, Branca L, Radinovic A, Ram P, El-Zein RS, Flautt T, Ding WY, Sayegh B, Benito-Gonzalez T, Lee O-H, Badejoko SO, Paitazoglou C, Karim N, Zaghloul AM, Agrawal H, Kaplan RM, Alli O, Ahmed A, Suradi HS, Knight BP, Alla VM, Panaich SS, Wong T, Bergmann MW, Chothia R, Kim J-S, Perez de Prado A, Bazaz R, Gupta D, Valderrabano M, Sanchez CE, El Chami MF, Mazzone P, Adamo M, Ling F, Wang DD, O'Neill W, Wojakowski W, Pershad A, Berti S, Spoon D, Kawsara A, Jabbour G, Boersma LVA, Schmidt B, Nielsen-Kudsk JE, Rodes-Cabau J, Freixa X, Ellis CR, Fauchier L, Demkow M, Sievert H, Main ML, Hibbert B, Holmes DR, Alkhouli Met al., 2021, Predictors of Device-Related Thrombus Following Percutaneous Left Atrial Appendage Occlusion, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 78, Pages: 297-313, ISSN: 0735-1097

Journal article

Maclean E, Simon R, Ang R, Dhillon G, Ahsan S, Khan F, Earley M, Lambiase PD, Rosengarten J, Chow AW, Dhinoja M, Providencia R, Markides V, Wong T, Hunter RJ, Behar JMet al., 2021, A multi-center experience of ablation index for evaluating lesion delivery in typical atrial flutter, PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, Vol: 44, Pages: 1039-1046, ISSN: 0147-8389

Journal article

Shi R, Chen Z, Pope MTB, Zaman JAB, Debney M, Marinelli A, Boyalla V, Sathishkumar A, Karim N, Cantor E, Valli H, Haldar S, Jones DG, Hussain W, Markides V, Betts TR, Wong Tet al., 2021, Individualized ablation strategy to treat persistent atrial fibrillation: Core-to-boundary approach guided by charge-density mapping, HEART RHYTHM, Vol: 18, Pages: 862-870, ISSN: 1547-5271

Journal article

Ali AN, Riad O, Tawfik M, Opel A, Wong Tet al., 2021, Newer generation cryoballoon vs. contact force-sensing radiofrequency ablation catheter in the ablation of paroxysmal atrial fibrillation., Herzschrittmacherther Elektrophysiol, Vol: 32, Pages: 236-243

BACKGROUND: Catheter ablation for atrial fibrillation (AF) has become an effective treatment to control symptoms. The second generation cryoballoon (CB) was designed for more efficient and homogenous freeze. Radiofrequency (RF) ablation catheters using three-dimensional electroanatomical mapping with the use of contact-force radiofrequency (CF RF) technology has achieved good results in several studies. OBJECTIVES: To compare the efficacy and safety of second-generation CB ablation in contrast to CF RF ablation in the ablation of paroxysmal AF. METHODS: A total of 81 consecutive patients suffering from paroxysmal AF underwent pulmonary vein isolation (PVI) either by the second generation cryoballoon (n = 44) or a contact force-sensing RF catheter (n = 37). The study was conducted at Ain Shams University Hospitals and Royal Brompton & Harefield NHS trust. Baseline data, procedural data and patient follow up-at 3, 6 and 12 months-were collected and analysed. RESULTS: The mean age was 53.8 ± 15 years in the CB group and 62.4 ± 12 years in the RF group, females representing 40.9% and 48.6% respectively. The baseline characteristics were comparable, but the CB group had less left atrial diameter and more left ventricular ejection fraction. The CB procedure was shorter (94.4 ± 39.3 vs. 140.8 ± 44.3 min, p < 0.0001), with longer fluoroscopy time (30 vs. 15.1 min, p = 0.047). Procedural complications were comparable between the two groups (CB 4.6%, CF RF 2.7%, p = 0.411). After 1 year, the recurrence rate in the CB group was similar to RF (27.3% vs. 27% respectively, p = 0.980). CONCLUSION: Second-generation CB ablation of paroxysmal AF has similar efficacy and safety to contact force-sensing RF catheters, with shorter procedure times and more fluoroscopy.

Journal article

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