92 results found
Scott G, Zetterberg H, Jolly A, et al., 2018, Minocycline reduces chronic microglial activation after brain trauma but increases neurodegeneration, BRAIN, Vol: 141, Pages: 459-471, ISSN: 0006-8950
Glaysher MA, Mohanaruban A, Prechtl CG, et al., 2017, A randomised controlled trial of a duodenal-jejunal bypass sleeve device (EndoBarrier) compared with standard medical therapy for the management of obese subjects with type 2 diabetes mellitus, BMJ OPEN, Vol: 7, ISSN: 2044-6055
Tan CL, Alavi SA, Baldeweg SE, et al., 2017, The screening and management of pituitary dysfunction following traumatic brain injury in adults: British Neurotrauma Group guidance, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 88, Pages: 971-981, ISSN: 0022-3050
Feeney C, Sharp DJ, Hellyer PJ, et al., 2017, Serum IGF-I levels are associated with improved white matter recovery after TBI., Annals of Neurology, Vol: 82, Pages: 30-43, ISSN: 0364-5134
OBJECTIVE: Traumatic brain injury (TBI) is a common disabling condition with limited treatment options. Diffusion tensor imaging (DTI) measures recovery of axonal injury in white matter (WM) tracts after TBI. Growth hormone deficiency (GHD) after TBI may impair axonal and neuropsychological recovery, and serum IGF-I may mediate this effect. We conducted a longitudinal study to determine the effects of baseline serum IGF-I concentrations on WM tract and neuropsychological recovery after TBI. METHODS: Thirty-nine adults after TBI (84.6% male; age median 30.5y; 87.2% moderate-severe; time since TBI median 16.3 months, n=4 with GHD) were scanned twice, 13.3 months (12.1-14.9) apart, and 35 healthy controls scanned once. Symptom and quality of life questionnaires and cognitive assessments were completed at both visits (n=33). Our main outcome measure was fractional anisotropy (FA), a measure of WM tract integrity, in a priori regions of interest: splenium of corpus callosum (SPCC), and posterior limb of internal capsule (PLIC). RESULTS: At baseline, FA was reduced in many WM tracts including SPCC and PLIC following TBI compared to controls, indicating axonal injury, with longitudinal increases indicating axonal recovery. There was a significantly greater increase in SPCC FA over time in patients with serum IGF-I above vs. below the median-for-age. Only the higher IGF-I group had significant improvements in immediate verbal memory recall over time. INTERPRETATION: WM recovery and memory improvements after TBI were greater in patients with higher serum IGF-I at baseline. These findings suggest that GH/IGF-I system may be a potential therapeutic target following TBI. This article is protected by copyright. All rights reserved.
Miras AD, Herring R, Vusirikala A, et al., 2017, Measurement of hepatic insulin sensitivity early after the bypass of the proximal small bowel in humans, OBESITY SCIENCE & PRACTICE, Vol: 3, Pages: 95-98, ISSN: 2055-2238
Limbrick-Oldfield EH, Mick I, Cocks RE, et al., 2017, Neural substrates of cue reactivity and craving in gambling disorder, TRANSLATIONAL PSYCHIATRY, Vol: 7, ISSN: 2158-3188
Feeney C, Scott G, Raffel J, et al., 2016, Kinetic analysis of the translocator protein positron emission tomography ligand [F-18]GE-180 in the human brain, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 43, Pages: 2201-2210, ISSN: 1619-7070
Jamall OA, Feeney C, Zaw-Linn J, et al., 2016, Prevalence and correlates of vitamin D deficiency in adults after traumatic brain injury, CLINICAL ENDOCRINOLOGY, Vol: 85, Pages: 636-644, ISSN: 0300-0664
Byrne CS, Chambers ES, Alhabeeb H, et al., 2016, Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 104, Pages: 5-14, ISSN: 0002-9165
Iacovazzo D, Caswell R, Bunce B, et al., 2016, Germline or somatic GPR101 duplication leads to X-linked acrogigantism: a clinico-pathological and genetic study, ACTA NEUROPATHOLOGICA COMMUNICATIONS, Vol: 4, ISSN: 2051-5960
Goldstone AP, Miras AD, Scholtz S, et al., 2016, Link Between Increased Satiety Gut Hormones and Reduced Food Reward After Gastric Bypass Surgery for Obesity, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 101, Pages: 599-609, ISSN: 0021-972X
Scholtz S, Goldstone AP, le Roux CW, 2015, Changes in Reward after Gastric Bypass: the Advantages and Disadvantages, CURRENT ATHEROSCLEROSIS REPORTS, Vol: 17, ISSN: 1523-3804
Alsters SIM, Goldstone AP, Buxton JL, et al., 2015, Truncating Homozygous Mutation of Carboxypeptidase E (CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual Disability and Hypogonadotrophic Hypogonadism, PLOS ONE, Vol: 10, ISSN: 1932-6203
Scheimann AO, Nadler EE, Driscoll DJ, et al., 2015, Laparoscopic Sleeve Gastrectomy in 108 Obese Children and Adolescents Ages 5 to 21 Years by Alqahtani AR, Antonisamy B, Alamri H, Elahmedi M, Zimmerman VA, ANNALS OF SURGERY, Vol: 261, Pages: E118-E118, ISSN: 0003-4932
Sam AH, Sleeth ML, Thomas EL, et al., 2015, Circulating Pancreatic Polypeptide Concentrations Predict Visceral and Liver Fat Content, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 100, Pages: 1048-1052, ISSN: 0021-972X
, 2015, Hypothalamic obesity in children
© 2015 S. Karger AG, Basel. Hypothalamic obesity (HyOb) is a severe and rapidly developing form of obesity that was initially described in patients with hypothalamic tumours and surgical damage. However, this definition has now expanded to include obesity developing after a variety of insults to hypothalamic centres, such as infections, infiltrations, trauma, vascular problems, and hydrocephalus in addition to acquired or congenital functional defects in central energy homeostasis. The pathogenetic mechanisms underlying HyOb are complex and multifactorial. Weight gain results from damage to the ventromedial hypothalamus, which may lead to hyperphagia, a low resting metabolic rate, autonomic imbalance, growth hormone, gonadotropin and thyroid-stimulating hormone deficiencies, hypomobility and insomnia. Disruption of leptin signalling and decreased central sympathetic output seem to have a critical role in the development of HyOb. Surgical strategies to preserve hypothalamic integrity are mandatory for the prevention of HyOb in patients with craniopharyngioma or other hypothalamic tumours. At present, there is no standard pharmacological intervention that has been shown to consistently help these complicated patients. In select cases, octreotide seems to be effective when introduced early after the cranial insult. The safety and effectiveness of bariatric surgery in the management of HyOb has also not been well established. A general overview on HyOb with special emphasis on craniopharyngioma and Prader-Willi syndrome is provided in this chapter.
Kweh FA, Miller JL, Sulsona CR, et al., 2015, Hyperghrelinemia in Prader-Willi Syndrome Begins in Early Infancy Long Before the Onset of Hyperphagia, AMERICAN JOURNAL OF MEDICAL GENETICS PART A, Vol: 167, Pages: 69-79, ISSN: 1552-4825
Daud NM, Ismail NA, Thomas EL, et al., 2014, The Impact of Oligofructose on Stimulation of Gut Hormones, Appetite Regulation and Adiposity, OBESITY, Vol: 22, Pages: 1430-1438, ISSN: 1930-7381
Miras AD, Scholtz S, Chhina N, et al., 2014, Role for Increased Plasma PYY and GLP-1 in Reducing Anticipatory Food Reward after Gastric Bypass Surgery, ENDOCRINE REVIEWS, Vol: 35, ISSN: 0163-769X
Scholtz S, Miras AD, Chhina N, et al., 2014, Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding, GUT, Vol: 63, Pages: 891-902, ISSN: 0017-5749
Goldstone AP, Prechtl CG, Scholtz S, et al., 2014, Ghrelin mimics fasting to enhance human hedonic, orbitofrontal cortex, and hippocampal responses to food, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 99, Pages: 1319-1330, ISSN: 0002-9165
Heymsfield SB, Avena NM, Baier L, et al., 2014, Hyperphagia: Current Concepts and Future Directions Proceedings of the 2nd International Conference on Hyperphagia, OBESITY, Vol: 22, Pages: S1-S17, ISSN: 1930-7381
Baxter D, Sharp DJ, Feeney C, et al., 2013, Pituitary Dysfunction after Blast Traumatic Brain Injury: The UK BIOSAP Study, ANNALS OF NEUROLOGY, Vol: 74, Pages: 527-536, ISSN: 0364-5134
Bonnefond A, Raimondo A, Stutzmann F, et al., 2013, Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features, JOURNAL OF CLINICAL INVESTIGATION, Vol: 123, Pages: 3037-3041, ISSN: 0021-9738
Deal CL, Tony M, Hoybye C, et al., 2013, Growth Hormone Research Society Workshop Summary: Consensus Guidelines for Recombinant Human Growth Hormone Therapy in Prader-Willi Syndrome, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 98, Pages: E1072-E1087, ISSN: 0021-972X
Cegla J, Jones B, Seyani L, et al., 2013, Comparison of the overnight metyrapone and glucagon stimulation tests in the assessment of secondary hypoadrenalism, CLINICAL ENDOCRINOLOGY, Vol: 78, Pages: 738-742, ISSN: 0300-0664
Goldstone AP, Holland AJ, Butler JV, et al., 2012, Appetite hormones and the transition to hyperphagia in children with Prader-Willi syndrome, INTERNATIONAL JOURNAL OF OBESITY, Vol: 36, Pages: 1564-1570, ISSN: 0307-0565
, 2012, Primary lymph node gastrinoma or metastatic gastrinoma with unidentified primary tumor site?, World Journal of Endocrine Surgery, Vol: 4, Pages: 66-70, ISSN: 0975-5039
Gastrinomas are neuroendocrine tumors that secrete gastrin and result in a clinical syndrome of peptic ulcer disease first described by Zollinger and Ellison in 1955.1 They present either sporadically or as a component of a hereditary determined syndrome, multiple endocrine neoplasia type 1. They are usually located in the pancreas and duodenum but have been reported to occur in both abdominal and extraabdominal sites.2 Reports of clinical and biochemical cure following resection of lymph nodes found to contain gastrinomas, in patients without a localized primary tumor, led investigators to cite the existence of the primary lymph node gastrinoma. Whether these cases represent metastatic disease from an, as yet, unidentified primary tumor, or de novo occurrence of a gastrinoma in a lymph node remains controversial. While some authors report that primary lymph node gastrinomas account for up to 10% of sporadic gastrinomas3,4 others question this theory, hypothesizing that their presentation represents an undetected microgastrinoma with metastatic lymph node involvement.5 Herewith, we report on a patient with Zollinger-Ellison syndrome in whom a peripancreatic lymph node with evidence of gastrinoma is the only apparent morphologic manifestation of the disease.
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