Publications
148 results found
Goldstone AP, Brynes AE, Thomas EL, et al., 2002, Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 75, Pages: 468-475, ISSN: 0002-9165
- Author Web Link
- Cite
- Citations: 69
Goldstone AP, Unmehopa UA, Bloom SR, et al., 2002, Hypothalamic NPY and agouti-related protein are increased in human illness but not in Prader-Willi syndrome and other obese subjects, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 87, Pages: 927-937, ISSN: 0021-972X
- Author Web Link
- Cite
- Citations: 70
Goldstone AP, Thomas EL, Brynes AE, et al., 2001, Visceral adipose tissue and metabolic complications of obesity are reduced in Prader-Willi syndrome female adults: Evidence for novel influences on body fat distribution, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 86, Pages: 4330-4338, ISSN: 0021-972X
- Author Web Link
- Cite
- Citations: 130
Thomas EL, Brynes AE, McCarthy J, et al., 2000, Preferential loss of visceral fat following aerobic exercise, measured by magnetic resonance imaging, LIPIDS, Vol: 35, Pages: 769-776, ISSN: 0024-4201
- Author Web Link
- Cite
- Citations: 77
Iqbal S, Grimwade D, Chase A, et al., 2000, Identification of <i>PML/RAR</i>α rearrangements in suspected acute promyelocytic leukemia using fluorescence <i>in situ</i> hybridization of bone marrow smears:: a comparison with cytogenetics and RT-PCR in MRC ATRA trial patients, LEUKEMIA, Vol: 14, Pages: 950-953, ISSN: 0887-6924
- Author Web Link
- Cite
- Citations: 8
Goldstone AP, Morgan I, Mercer JG, et al., 2000, Effect of leptin on hypothalamic GLP-1 peptide and brain-stem pre-proglucagon mRNA, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 269, Pages: 331-335, ISSN: 0006-291X
- Author Web Link
- Cite
- Citations: 53
de Silva AM, Walder KR, Aitman TJ, et al., 1999, Combination of polypmorphisms in OB-R and the OB gene associated with insulin resistance in Nauruan males, INTERNATIONAL JOURNAL OF OBESITY, Vol: 23, Pages: 816-822, ISSN: 0307-0565
- Author Web Link
- Cite
- Citations: 29
Allford S, Grimwade D, Langabeer S, et al., 1999, Identification of the t(15;17) in AML FAB types other than M3: evaluation of the role of molecular screening for the PML/RARalpha rearrangement in newly diagnosed AML. The Medical Research Council (MRC) Adult Leukaemia Working Party., Br J Haematol, Vol: 105, Pages: 198-207, ISSN: 0007-1048
Acute promyelocytic leukaemia (APL) is characterized by the t(15;17) leading to the formation of PML-RARalpha and RARalpha-PML fusion genes; this rearrangement has been considered both diagnostic for, and restricted to, this subtype of acute myeloid leukaemia (AML FAB M3). We describe two cases of AML with the t(15;17) associated with a PML/RARalpha rearrangement which lacked typical APL morphology, classified as FAB M1 and M2 respectively. In both cases morphological review revealed small populations of cells which exhibited some features associated with APL. In the case classified as M1, PML immunofluorescence studies revealed the classic microparticulate nuclear staining pattern as observed in typical cases of APL with the t(15;17). Similarly, blasts from this case were found to be sensitive to ATRA in vitro as determined by NBT reduction test and by normalization of the PML nuclear body staining pattern. To determine the frequency of PML/RARalpha rearrangements in FAB subtypes other than M3, 530 patients from the MRC AML trials were screened using nested RT-PCR. Only one individual, initially classified as M5 with a normal karyotype, was found to have a PML/RARalpha rearrangement. The diagnosis was revised to M3 variant on subsequent morphological review. In conclusion, this study demonstrates that, in rare cases, the t(15;17) is not restricted to patients with M3 morphology as defined by current FAB criteria. Therefore, although we consider cytogenetic analysis of newly diagnosed cases of AML to be mandatory, our data suggests that routine molecular screening for PML/RARalpha rearrangements is not justified and should be reserved for those cases displaying features which may be suspicious of APL even if such cells comprise only a minority of the total population.
Allford S, Grimwade D, Langabeer S, et al., 1999, Identification of the t(15;17) in AML FAB types other than M3:: evaluation of the role of molecular screening for the <i>PML/RAR</i>α rearrangement in newly diagnosed AML, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 105, Pages: 198-207, ISSN: 0007-1048
- Author Web Link
- Cite
- Citations: 36
Meeran K, O'Shea D, Edwards CM, et al., 1999, Repeated Intracerebroventricular Administration of Glucagon-Like Peptide-1-(7-36) Amide or Exendin-(9-39) Alters Body Weight in the Rat* *This work was supported by the United Kingdom Medical Research Council., Endocrinology, Vol: 140, Pages: 244-250
Meeran K, O'Shea D, Edwards CMB, et al., 1999, Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat, ENDOCRINOLOGY, Vol: 140, Pages: 244-250, ISSN: 0013-7227
- Author Web Link
- Cite
- Citations: 255
Thomas EL, Saeed N, Hajnal JV, et al., 1998, Magnetic resonance imaging of total body fat, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 85, Pages: 1778-1785, ISSN: 8750-7587
- Author Web Link
- Cite
- Citations: 233
Rossi M, Kim MS, Morgan DGA, et al., 1998, A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone <i>in vivo</i>, ENDOCRINOLOGY, Vol: 139, Pages: 4428-4431, ISSN: 0013-7227
- Author Web Link
- Cite
- Citations: 471
Morgan DGA, Small CJ, Abusnana S, et al., 1998, The NPY Y1 receptor antagonist BIBP 3226 blocks NPY induced feeding via a non-specific mechanism, REGULATORY PEPTIDES, Vol: 75-6, Pages: 377-382, ISSN: 0167-0115
- Author Web Link
- Cite
- Citations: 45
Grimwade D, Gorman P, Duprez E, et al., 1997, Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia, BLOOD, Vol: 90, Pages: 4876-4885, ISSN: 0006-4971
- Author Web Link
- Cite
- Citations: 118
Small CJ, Morgan DGA, Meeran K, et al., 1997, Peptide analogue studies of the hypothalamic neuropeptide Y receptor mediating pituitary adrenocorticotrophic hormone release, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 94, Pages: 11686-11691, ISSN: 0027-8424
- Author Web Link
- Cite
- Citations: 54
Goldstone AP, Mercer JG, Gunn I, et al., 1997, Leptin interacts with glucagon-like peptide-1 neurons to reduce food intake and body weight in rodents, FEBS LETTERS, Vol: 415, Pages: 134-138, ISSN: 0014-5793
- Author Web Link
- Cite
- Citations: 120
Rossi M, Small CJ, Goldstone AP, et al., 1997, Melanin concentrating hormone (MCH) concentration is increased in the hypothalamus of obese Zucker rats, DIABETOLOGIA, Vol: 40, Pages: 1054-1054, ISSN: 0012-186X
- Author Web Link
- Cite
- Citations: 1
Gotoda T, Manning BS, Goldstone AP, et al., 1997, Leptin receptor gene variation and obesity: Lack of association in a white British male population, HUMAN MOLECULAR GENETICS, Vol: 6, Pages: 869-876, ISSN: 0964-6906
- Author Web Link
- Cite
- Citations: 159
Rees D, Grimwade D, Langabeer S, et al., 1997, Influence of genetic predisposition to thrombosis on natural history of acute promyelocytic leukaemia, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 96, Pages: 490-492, ISSN: 0007-1048
- Author Web Link
- Cite
- Citations: 19
Goldstone AP, ScottCoombes DM, Lynn JA, 1996, Surgical management of gastrointestinal endocrine tumours, BAILLIERES CLINICAL GASTROENTEROLOGY, Vol: 10, Pages: 707-736, ISSN: 0950-3528
- Author Web Link
- Cite
- Citations: 7
Gratwohl A, Gorin C, Apperley J, et al., 1996, The European Group for Blood and Marrow Transplantation (EBMT): A report from the President and the Chairmen of the Working Parties, BONE MARROW TRANSPLANTATION, Vol: 18, Pages: 677-691, ISSN: 0268-3369
- Author Web Link
- Cite
- Citations: 5
Grimwade D, Howe K, Langabeer S, et al., 1996, Establishing the presence of the t(15;17) in suspected acute promyelocytic leukaemia: Cytogenetic, molecular and PML immunofluorescence assessment of patients entered into the MRC ATRA trial, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 94, Pages: 557-573, ISSN: 0007-1048
- Author Web Link
- Cite
- Citations: 105
Grimwade D, Howe K, Langabeer S, et al., 1996, Establishing the presence of the t(15;17) in suspected acute promyelocytic leukaemia: cytogenetic, molecular and PML immunofluorescence assessment of patients entered into the M.R.C. ATRA trial. M.R.C. Adult Leukaemia Working Party., Br J Haematol, Vol: 94, Pages: 557-573, ISSN: 0007-1048
Detection of the t(15;17) or its molecular consequence, the PML-RAR alpha rearrangement, is critical for meaningful analysis of clinical trials involving patients with suspected acute promyelocytic leukaemia (APL). Its presence remains the best predictor of a favourable response to retinoids, such as ATRA, which in combination with chemotherapy confer significant improvements in disease-free survival. We have evaluated the relative efficacy of RT-PCR, cytogenetics and PML immunofluorescence staining to identify the existence of the translocation in 100 patients entered into the Medical Research Council (M.R.C.) ATRA trial. RT-PCR successfully identified PML-RAR alpha rearrangements in 93/100 patients, including 65 where only peripheral blood or post-induction marrow samples were available for analysis and in 12 patients in whom cytogenetic assessment failed to demonstrate t(15;17) due to poor-quality metaphases (10/12) or as a reflection of cryptic PML-RAR alpha rearrangements (2/12). Parallel employment of the RAR alpha-PML assay confirmed expression of del(17q)-derived transcripts in 81% and permitted determination of the PML breakpoint (a potential independent prognostic variable) in all 93 cases. Sequencing of RT-PCR products derived from 50 patients with 3' PML breakpoints revealed five bcr 2 cases, including a novel exon 5 breakpoint. 35/81 (43%) patients with cytogenetic evidence of t(15;17) possessed additional karyotypic abnormalities. In four patients with available buffy coat smears, lack of cytogenetic or molecular evidence of the t(15;17) was confirmed by a wild-type PML immunofluorescence nuclear staining pattern, in contrast to the characteristic microparticulate distribution detected in 14 patients with RT-PCR evidence of the rearrangement. However, although PML immunofluorescence staining is suitable for rapid determination of patients likely to benefit from ATRA, this approach does not obviate the need for cytogenetic and RT-PCR analysis of all pat
Grimwade D, Howe K, Davies L, et al., 1996, Establishing the presence of the t(15;17) in suspected APL: Cytogenetic, molecular and PML immunofluorescence assessment of patients entered into the UK MRC ATRA trial, Publisher: BLACKWELL SCIENCE LTD, Pages: 831-831, ISSN: 0007-1048
Grimwade D, Davies L, Howe K, et al., 1996, Establishing the presence of t(15;17) in patients with suspected APL, entered into the MRC ATRA study, by PML immunofluorescence staining, Publisher: WILEY-BLACKWELL, Pages: 203-203, ISSN: 0007-1048
Grimwade D, Howe K, Langabeer S, et al., 1996, Minimal residual disease detection in acute promyelocytic leukemia by reverse-transcriptase PCR: Evaluation of PML-RAR alpha and RAR alpha-PML assessment in patients who ultimately relapse, LEUKEMIA, Vol: 10, Pages: 61-66, ISSN: 0887-6924
- Author Web Link
- Cite
- Citations: 66
MARTENSZ ND, GOLDSTONE AP, STUART E, et al., 1990, INTERACTIONS BETWEEN OPIOID-PEPTIDES AND ADRENALINE-CONTAINING NEURONS MODULATE LUTEINIZING-HORMONE SECRETION IN MALE-RATS, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 2, Pages: 71-77, ISSN: 0953-8194
- Author Web Link
- Cite
- Citations: 2
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.