Imperial College London
Alternate

Dr Tony Goldstone

Faculty of Medicine, Department of Brain Sciences

Reader in PsychoNeuroEndocrinology
 
 
 
//

Contact

 

+44 (0)20 7594 5989tony.goldstone Website

 
 
//

Location

 

S25Commonwealth BuildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Sjostrom:2021:10.3390/jcm10163613,
author = {Sjostrom, A and Pellikaan, K and Sjostrom, H and Goldstone, AP and Grugni, G and Crino, A and De, Graaff LCG and Hoybye, C},
doi = {10.3390/jcm10163613},
journal = {Journal of Clinical Medicine},
title = {Hyperprolactinemia in adults with Prader-Willi syndrome},
url = {http://dx.doi.org/10.3390/jcm10163613},
volume = {10},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Prader-Willi syndrome (PWS) is a rare neurodevelopmental genetic disorder typically characterized by body composition abnormalities, hyperphagia, behavioural challenges, cognitive dysfunction, and hypogonadism. Psychotic illness is common, particularly in patients with maternal uniparental disomy (mUPD), and antipsychotic medications can result in hyperprolactinemia. Information about hyperprolactinemia and its potential clinical consequences in PWS is sparse. Here, we present data from an international, observational study of 45 adults with PWS and hyperprolactinemia. Estimated prevalence of hyperprolactinemia in a subset of centres with available data was 22%, with 66% of those related to medication and 55% due to antipsychotics. Thirty-three patients were men, 12 women. Median age was 29 years, median BMI 29.8 kg/m2, 13 had mUPD. Median prolactin was 680 mIU/L (range 329–5702). Prolactin levels were higher in women and patients with mUPD, with only 3 patients having severe hyperprolactinemia. Thyroid function tests were normal, 24 were treated with growth hormone, 29 with sex steroids, and 20 with antipsychotic medications. One patient had kidney insufficiency, and one a microprolactinoma. In conclusion, severe hyperprolactinemia was rare, and the most common aetiology of hyperprolactinemia was treatment with antipsychotic medications. Although significant clinical consequences could not be determined, potential negative long-term effects of moderate or severe hyperprolactinemia cannot be excluded. Our results suggest including measurements of prolactin in the follow-up of adults with PWS, especially in those on treatment with antipsychotics
AU  - Sjostrom,A
AU  - Pellikaan,K
AU  - Sjostrom,H
AU  - Goldstone,AP
AU  - Grugni,G
AU  - Crino,A
AU  - De,Graaff LCG
AU  - Hoybye,C
DO  - 10.3390/jcm10163613
PY  - 2021///
SN  - 2077-0383
TI  - Hyperprolactinemia in adults with Prader-Willi syndrome
T2  - Journal of Clinical Medicine
UR  - http://dx.doi.org/10.3390/jcm10163613
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000690476400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.mdpi.com/2077-0383/10/16/3613
UR  - http://hdl.handle.net/10044/1/95372
VL  - 10
ER  -
Download