Imperial College London
Alternate

Dr Tony Goldstone

Faculty of Medicine, Department of Brain Sciences

Reader in PsychoNeuroEndocrinology
 
 
 
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Contact

 

+44 (0)20 7594 5989tony.goldstone Website

 
 
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Location

 

S25Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Howell:2023:10.1002/osp4.652,
author = {Howell, TA and Matza, LS and Mallya, UG and Goldstone, AP and Butsch, WS and Lazarus, E},
doi = {10.1002/osp4.652},
journal = {Obesity Science and Practice},
pages = {376--382},
title = {Health state utilities associated with hyperphagia: data for use in cost-utility models},
url = {http://dx.doi.org/10.1002/osp4.652},
volume = {9},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectiveRare genetic diseases of obesity typically present with hyperphagia, a pathologic desire to consume food. Cost-utility models assessing the value of treatments for these rare diseases will require health state utilities representing hyperphagia. This study estimated utilities associated with various hyperphagia severity levels.MethodsFour health state vignettes were developed using published literature and clinician input to represent various severity levels of hyperphagia. Utilities were estimated for these health states in a time trade-off elicitation study in a UK general population sample.ResultsIn total, 215 participants completed interviews (39.5% male; mean age 39.1 years). Mean (SD) utilities were 0.98 (0.02) for no hyperphagia, 0.91 (0.10) for mild hyperphagia, 0.70 (0.30) for moderate hyperphagia, and 0.22 (0.59) for severe hyperphagia. Mean (SD) disutilities were −0.08 (0.10) for mild, −0.28 (0.30) for moderate, and −0.77 (0.58) for severe hyperphagia.ConclusionsThese data show increasing severity of hyperphagia is associated with decreased utility. Utilities associated with severe hyperphagia are similar to those of other health conditions severely impacting quality of life (QoL). These findings highlight that treatments addressing substantial QoL impacts of severe hyperphagia are needed. Utilities estimated here may be useful in cost-utility models of treatments for rare genetic diseases of obesity.
AU  - Howell,TA
AU  - Matza,LS
AU  - Mallya,UG
AU  - Goldstone,AP
AU  - Butsch,WS
AU  - Lazarus,E
DO  - 10.1002/osp4.652
EP  - 382
PY  - 2023///
SN  - 2055-2238
SP  - 376
TI  - Health state utilities associated with hyperphagia: data for use in cost-utility models
T2  - Obesity Science and Practice
UR  - http://dx.doi.org/10.1002/osp4.652
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000922753300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/10.1002/osp4.652
UR  - http://hdl.handle.net/10044/1/102173
VL  - 9
ER  -
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