Imperial College London
Alternate

Dr Tony Goldstone

Faculty of Medicine, Department of Brain Sciences

Reader in PsychoNeuroEndocrinology
 
 
 
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Contact

 

+44 (0)20 7594 5989tony.goldstone Website

 
 
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Location

 

S25Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Miras:2016:10.1002/osp4.76,
author = {Miras, AD and Herring, R and Vuisrikala, A and Shojaee-Moradi, F and Jackson, NC and Chandaria, S and Jackson, SN and Goldstone, AP and Hakim, N and Patel, A and Umpleby, AM and le, Roux CW},
doi = {10.1002/osp4.76},
journal = {Obesity Science & Practice},
pages = {95--98},
title = {Measurement of hepatic insulin sensitivity early after the bypass of the proximal small bowel in humans},
url = {http://dx.doi.org/10.1002/osp4.76},
volume = {3},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective: Unlike gastric banding or sleeve gastrectomy procedures, intestinal bypass procedures, and the Roux-en-Y gastric bypass (RYGB) in particular, lead to rapid improvements in glycaemia early after surgery. The bypass of the proximal small bowel may have weight loss and even caloric restriction independent glucose-lowering properties on hepatic insulin sensitivity. In this first in humans mechanistic study, we examined this hypothesis by investigating the early effects of the duodeno-jejunal bypass liner (DJBL; GI Dynamics, USA) on the hepatic insulin sensitivity using the gold standard euglycaemic hyperinsulinaemic clamp methodology. Method: Seven patients with obesity underwent measurement of hepatic insulin sensitivity at baseline, one week after a low-calorie liquid diet and after a further one week following insertion of the DJBL whilst on the same diet.Results: DJBL did not improve the insulin sensitivity of hepatic glucose production (HGP) beyond the improvements achieved with caloric restriction. Conclusions: Caloric restriction may be the predominant driver of early increases in hepatic insulin sensitivity after the endoscopic bypass of the proximal small bowel. The same mechanism may be at play after RYGB and explain, at least in part, the rapid improvements in glycaemia.
AU  - Miras,AD
AU  - Herring,R
AU  - Vuisrikala,A
AU  - Shojaee-Moradi,F
AU  - Jackson,NC
AU  - Chandaria,S
AU  - Jackson,SN
AU  - Goldstone,AP
AU  - Hakim,N
AU  - Patel,A
AU  - Umpleby,AM
AU  - le,Roux CW
DO  - 10.1002/osp4.76
EP  - 98
PY  - 2016///
SN  - 2055-2238
SP  - 95
TI  - Measurement of hepatic insulin sensitivity early after the bypass of the proximal small bowel in humans
T2  - Obesity Science & Practice
UR  - http://dx.doi.org/10.1002/osp4.76
UR  - http://hdl.handle.net/10044/1/40634
VL  - 3
ER  -
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