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@article{Belramman:2022:10.1001/jamasurg.2022.0298,
author = {Belramman, A and Bootun, R and Tang, TY and Lane, TRA and Davies, AH},
doi = {10.1001/jamasurg.2022.0298},
journal = {JAMA Surgery},
pages = {395--404},
title = {Pain outcomes in a multicentre randomised clinical trial comparing MechanOChemical ablation versus CyanoAcrylate Adhesive for the treatment of primary truncal saphenous veins incompetence},
url = {http://dx.doi.org/10.1001/jamasurg.2022.0298},
volume = {157},
year = {2022}
}

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TY  - JOUR
AB  - Importance  Endovenous thermal ablations (ETAs) are recommended as first-line treatment for truncal vein reflux, have a short recovery time, and are cost-effective. However, ETAs are associated with discomfort during tumescent anesthesia infiltration. To minimize discomfort, nonthermal, nontumescent ablation techniques had emerged in the form of mechanochemical ablation (MOCA) and cyanoacrylate adhesive injection (CAE).Objective  To assess pain scores immediately after truncal ablation using a 100-mm visual analog scale and 10-point number scale to compare pain-related outcomes following mechanochemical ablation vs cyanoacrylate adhesive treatment.Design, Setting, and Participants  The Multicenter Randomized II Clinical Trial Comparing Mechanochemical Ablation vs Cyanoacrylate Adhesive for the Treatment of Primary Truncal Saphenous Veins Incompetence study was a prospective multicenter randomized clinical trial conducted at 3 sites between November 2017 and January 2020. Inclusion criteria were primary great or small saphenous varicose veins; exclusion criteria included recurrent varicose veins, current deep venous thrombosis, or serious arterial disease. There were 392 participants screened, 225 were excluded, and 167 participants underwent randomization. Four participants did not receive allocated intervention and were included in the intention-to-treat analysis. Follow-up took place at 2 weeks, and 3, 6, and 12 months.Interventions  Patients with primary truncal vein incompetence were randomized to receive either MOCA or CAE.Main Outcomes and Measures  The primary outcome measure was pain score immediately after completing truncal ablation using a 100-mm visual analog scale (VAS) and a 10-point number scale. Secondary outcome measures included degree of ecchymosis, occlusion rates, clinical severity, and generic and disease-specific quality of life (QoL) scores.Results  Of 167 study participants, 99 (59.3%) were women, and the mean (SD) age was 56 (15.8) years. O
AU  - Belramman,A
AU  - Bootun,R
AU  - Tang,TY
AU  - Lane,TRA
AU  - Davies,AH
DO  - 10.1001/jamasurg.2022.0298
EP  - 404
PY  - 2022///
SN  - 2168-6262
SP  - 395
TI  - Pain outcomes in a multicentre randomised clinical trial comparing MechanOChemical ablation versus CyanoAcrylate Adhesive for the treatment of primary truncal saphenous veins incompetence
T2  - JAMA Surgery
UR  - http://dx.doi.org/10.1001/jamasurg.2022.0298
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000789285100003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://jamanetwork.com/journals/jamasurgery/fullarticle/2790976
UR  - http://hdl.handle.net/10044/1/109528
VL  - 157
ER  -

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