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@article{Pernaute:2014:10.1101/gad.245621.114,
author = {Pernaute, B and Spruce, T and Smith, KM and Sanchez-Nieto, JM and Manzanares, M and Cobb, B and Rodriguez, TA},
doi = {10.1101/gad.245621.114},
journal = {Genes and Development},
pages = {1873--1878},
title = {MicroRNAs control the apoptotic threshold in primed Pluripotent stem cells through regulation of BIM},
url = {http://dx.doi.org/10.1101/gad.245621.114},
volume = {28},
year = {2014}
}

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TY  - JOUR
AB  - Mammalian primed pluripotent stem cells have been shown to be highly susceptible to cell death stimuli due to their low apoptotic threshold, but how this threshold is regulated remains largely unknown. Here we identify microRNA (miRNA)-mediated regulation as a key mechanism controlling apoptosis in the post-implantation epiblast. Moreover, we found that three miRNA families, miR-20, miR-92, and miR-302, control the mitochondrial apoptotic machinery by fine-tuning the levels of expression of the proapoptotic protein BIM. These families therefore represent an essential buffer needed to maintain cell survival in stem cells that are primed for not only differentiation but also cell death.
AU  - Pernaute,B
AU  - Spruce,T
AU  - Smith,KM
AU  - Sanchez-Nieto,JM
AU  - Manzanares,M
AU  - Cobb,B
AU  - Rodriguez,TA
DO  - 10.1101/gad.245621.114
EP  - 1878
PY  - 2014///
SN  - 0890-9369
SP  - 1873
TI  - MicroRNAs control the apoptotic threshold in primed Pluripotent stem cells through regulation of BIM
T2  - Genes and Development
UR  - http://dx.doi.org/10.1101/gad.245621.114
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341674700003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/17908
VL  - 28
ER  -

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