Imperial College London
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ProfessorTristanRodriguez

Faculty of Medicine, National Heart & Lung Institute

Professor of Cell and Developmental Biology
 
 
 
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Contact

 

+44 (0)20 7594 5448tristan.rodriguez Website

 
 
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Location

 

331ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lima:2017:10.1016/bs.ctdb.2017.10.012,
author = {Lima, A and Burgstaller, J and Sanchez, Nieto JM and Rodriguez, T},
doi = {10.1016/bs.ctdb.2017.10.012},
journal = {Current Topics in Developmental Biology},
pages = {339--363},
title = {The mitochondria and the regulation of cell fitness during earlymammalian development},
url = {http://dx.doi.org/10.1016/bs.ctdb.2017.10.012},
volume = {128},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - From fertilization until the onset of gastrulation the early mammalian embryo undergoes a dramatic series of changes that converts a single fertilized cell into a remarkably complex organism. Much attention has been given to the molecular changes occurring during this process, but here we will review what is known about the changes affecting the mitochondria and how they impact on the energy metabolism and apoptotic response of the embryo. We will also focus on understanding what quality control mechanisms ensure optimal mitochondrial activity in the embryo, and in this way provide an overview of the importance of the mitochondria in determining cell fitness during early mammalian development.
AU  - Lima,A
AU  - Burgstaller,J
AU  - Sanchez,Nieto JM
AU  - Rodriguez,T
DO  - 10.1016/bs.ctdb.2017.10.012
EP  - 363
PY  - 2017///
SN  - 0070-2153
SP  - 339
TI  - The mitochondria and the regulation of cell fitness during earlymammalian development
T2  - Current Topics in Developmental Biology
UR  - http://dx.doi.org/10.1016/bs.ctdb.2017.10.012
UR  - http://hdl.handle.net/10044/1/55861
VL  - 128
ER  -
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