Imperial College London

DrUmaAnand

Faculty of MedicineDepartment of Surgery & Cancer

Research Fellow
 
 
 
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Contact

 

+44 (0)20 3313 2362u.anand

 
 
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Location

 

BN5Commonwealth BuildingHammersmith Campus

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Summary

 

Summary

Gap43 positive Rat DRG neuron

Gap43 positive DRG neuron (From: Roblin et al 2015) 


My research interest is in neuronal plasticity, investigating ion channel/receptor expression and mechanisms of neurodegeneration, using immunostaining techniques in transfected cells, and sensory neurons from rats and humans in models of neuronal hypersensitivity.  For functional studies I use calcium imaging, to identify novel drug targets and their mechanism of action, in pharmacological assays of potential drug molecules, for treating chronic pain.

I use cell based assays for morphological studies of substances such as chemotherapy agents and toxins such as mycolactone in DRG neurons, especially useful for neurotoxicology. I am also involved in live cell nano imaging of neuronal growth cones using Scanning Ion Conductance Microscopy in collaboration with Prof. Yuri Korchev.

This work has led to the identification of modulators of novel targets including the TrkA inhibitor CT327 for treating pruritis associated with psoriasis, and the Angiotensin II subtype 2 receptor (AT2R) antagonist, EMA401.

I followed my Masters in Life Sciences from the University of Bombay, with a Ph.D. in Neuroscience from the United Medical and Dental Schools of Guy's and St. Thomas's Hospitals, University of London, U.K. 


 

 

Publications

Journals

Privitera R, Anand P, Donatien P, et al., 2021, Capsaicin 8% patch treatment in non-freezing cold injury : evidence for pain relief and nerve regeneration., Frontiers in Neurology, ISSN:1664-2295

Anand U, Pacchetti B, Anand P, et al., 2021, Cannabis-based medicines and pain: a review of potential synergistic and entourage effects, Pain Management, Vol:11, ISSN:1758-1869, Pages:395-403

Anand U, Jones B, Korchev Y, et al., 2020, CBD effects on TRPV1 signaling pathways in cultured DRG neurons, Journal of Pain Research, Vol:2020, ISSN:1178-7090, Pages:2269-2278

Anand U, Korchev Y, Anand P, 2019, The role of urea in neuronal degeneration and sensitization: an in vitro model of uremic neuropathy, Molecular Pain, Vol:15, ISSN:1744-8069

Anand P, Elsafa E, Privitera R, et al., 2019, Rational treatment of chemotherapy-induced peripheral neuropathy with capsaicin 8% patch: from pain relief towards disease modification, Journal of Pain Research, Vol:12, ISSN:1178-7090, Pages:2039-2052

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