Gap43 positive DRG neuron (From: Roblin et al 2015)
My research interest is in neuronal plasticity, investigating ion channel/receptor expression and mechanisms of neurodegeneration, using immunostaining techniques in transfected cells, and sensory neurons from rats and humans in models of neuronal hypersensitivity. For functional studies I use calcium imaging, to identify novel drug targets and their mechanism of action, in pharmacological assays of potential drug molecules, for treating chronic pain.
I use cell based assays for morphological studies of substances such as chemotherapy agents and toxins such as mycolactone in DRG neurons, especially useful for neurotoxicology. I am also involved in live cell nano imaging of neuronal growth cones using Scanning Ion Conductance Microscopy in collaboration with Prof. Yuri Korchev.
This work has led to the identification of modulators of novel targets including the TrkA inhibitor CT327 for treating pruritis associated with psoriasis, and the Angiotensin II subtype 2 receptor (AT2R) antagonist, EMA401.
I followed my Masters in Life Sciences from the University of Bombay, with a Ph.D. in Neuroscience from the United Medical and Dental Schools of Guy's and St. Thomas's Hospitals, University of London, U.K.
et al., 2022, The endocannabinoid analgesic entourage effect: investigations in cultured DRG neurons, Journal of Pain Research, Vol:15, ISSN:1178-7090, Pages:3493-3507
et al., 2022, Reversing painful and non-painful diabetic neuropathy with the capsaicin 8% patch: Clinical evidence for pain relief and restoration of function via nerve fiber regeneration, Frontiers in Neurology, Vol:13, ISSN:1664-2295
et al., 2021, Dose-related inhibition of capsaicin responses by cannabinoids CBG, CBD, THC and their combination in cultured sensory neurons, Journal of Pain Research, Vol:14, ISSN:1178-7090, Pages:3603-3614
et al., 2021, Capsaicin 8% patch treatment in non-freezing cold injury : evidence for pain relief and nerve regeneration., Frontiers in Neurology, Vol:12, ISSN:1664-2295, Pages:1-10
et al., 2021, Cannabis-based medicines and pain: a review of potential synergistic and entourage effects, Pain Management, Vol:11, ISSN:1758-1869, Pages:395-403