Publications
36 results found
De Beule PAA, Dunsby C, Owen DM, et al., 2007, A novel hyperspectral lifetime probe for autofluorescence - art. no. 643303, Conference on Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VII, Pages: 43303-43303
The application of autofluorescence in non-invasive medical diagnostics could have great potential. Two major drawbacks inherent to this approach are low signal levels compared to those from exogenous fluorescent probes and complexity caused by the multiplicity of fluorescent biomolecules in tissue. Here we present a new optical system that is based on single channel detection via all optical fiber and call measure the fluorescence emission spectrum and fluorescence lifetime simultaneously for excitation wavelengths of 355 and 435nm. Single channel measurements integrate the signal normally available in all imaging setup and therefore have a better signal-to-noise ratio. Resolving both the fluorescence emission spectrum and fluorescence lifetime provides the opportunity to discriminate multiple fluorophores. This instrument is intended for NAD(P)H and flavin measurements for the dynamic monitoring of cellular metabolism and optical measurements of cancerous tissue. Initial results from a study of live cells and a clinical study of human skin lesions are presented.
Anand U, Otto WR, Casula MA, et al., 2006, The effect of neurotrophic factors on morphology, TRPV1 expression and capsaicin responses of cultured human DRG sensory neurons, NEUROSCIENCE LETTERS, Vol: 399, Pages: 51-56, ISSN: 0304-3940
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- Citations: 88
Anand U, Cohen J, McMahon SB, 2006, Preferential Growth of Neonatal Rat Dorsal Root Ganglion Cells on Homotypic Peripheral Newe Substrates ln vitro, European Journal of Neuroscience, ISSN: 1460-9568
Anand U, 2005, Anand, U. 2007. Mechanisms and Management of Cancer Pain. The Cancer Handbook., The Cancer Handbook, Editors: Alison, Publisher: Copyright © 2005 John Wiley & Sons, Ltd
Chronic intractable pain is experienced by an overwhelming majority of cancer patients, compromising their quality of life. The pain can be due to several causes: infiltration by tumours, bone metastases, or a consequence of therapy. The mainstay of analgesia has been opioid treatment of various formulations, but this is limited in efficacy and is not without considerable side effects. Recent advances in understanding the underlying pathophysiological and molecular mechanisms of cancer pain have been derived from animal models and related histopathological findings from chronic pain patients. The identification of novel drug targets, and their imminent clinical trials, provides the prospect of new treatments for alleviating cancer pain in the near future.
Taherzadeh O, Otto WR, Anand U, et al., 2003, Influence of human skin injury on regeneration of sensory neurons, CELL AND TISSUE RESEARCH, Vol: 312, Pages: 275-280, ISSN: 0302-766X
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- Citations: 16
Boettger MK, Till S, Chen AX, et al., 2002, Calcium-activated potassium channel SK1- and IK1-like immunoreactivity in injured human sensory neurones and its regulation by neurotrophic factors, BRAIN, Vol: 125, Pages: 252-263, ISSN: 0006-8950
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- Citations: 75
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