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@article{Anand:2021:10.2217/pmt-2020-0110,
author = {Anand, U and Pacchetti, B and Anand, P and Sodergren, MH},
doi = {10.2217/pmt-2020-0110},
journal = {Pain Management},
pages = {395--403},
title = {Cannabis-based medicines and pain: a review of potential synergistic and entourage effects},
url = {http://dx.doi.org/10.2217/pmt-2020-0110},
volume = {11},
year = {2021}
}

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TY  - JOUR
AB  - The recent legalization of medicinal cannabis in several jurisdictions has spurred the development of therapeutic formulations for chronic pain. Unlike pure delta-9-tetrahydrocannabinol (THC), full-spectrum products contain naturally occurring cannabinoids and have been reported to show improved efficacy or tolerability, attributed to synergy between cannabinoids and other components in the cannabis plant. Although ‘synergy’ indicates that two or more active compounds may produce an additive or combined effect greater than their individual analgesic effect, potentiation of the biological effect of a compound by related but inactive compounds, in combination, was termed the ‘entourage effect’. Here, we review current evidence for potential synergistic and entourage effects of cannabinoids in pain relief. However, definitive clinical trials and in vitro functional studies are still required.
AU  - Anand,U
AU  - Pacchetti,B
AU  - Anand,P
AU  - Sodergren,MH
DO  - 10.2217/pmt-2020-0110
EP  - 403
PY  - 2021///
SN  - 1758-1869
SP  - 395
TI  - Cannabis-based medicines and pain: a review of potential synergistic and entourage effects
T2  - Pain Management
UR  - http://dx.doi.org/10.2217/pmt-2020-0110
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000627472300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.futuremedicine.com/doi/10.2217/pmt-2020-0110
UR  - http://hdl.handle.net/10044/1/90468
VL  - 11
ER  -

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