Imperial College London
Alternate

ProfessorUtaGriesenbach

Faculty of Medicine, National Heart & Lung Institute

Professor of Molecular Medicine
 
 
 
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Contact

 

+44 (0)20 7594 7927u.griesenbach

 
 
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Assistant

 

Miss Samia Soussi +44 (0)20 7594 7980

 
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Location

 

Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

297 results found

Griesenbach U, Meng C, Farley R, Gardner A, Brake MA, Frankel GM, Gruenert DC, Cheng SH, Scheule RK, Alton EWFWet al., 2009, The role of doxorubicin in non-viral gene transfer in the lung, BIOMATERIALS, Vol: 30, Pages: 1971-1977, ISSN: 0142-9612

Journal article

Griesenbach U, Alton EWFW, 2009, Gene transfer to the lung: Lessons learned from more than 2 decades of CF gene therapy, ADVANCED DRUG DELIVERY REVIEWS, Vol: 61, Pages: 128-139, ISSN: 0169-409X

Journal article

Griesenbach U, Alton EWFW, 2009, Cystic fibrosis Ferreting with fibroblasts for cystic fibrosis, GENE THERAPY, Vol: 16, Pages: 1-2, ISSN: 0969-7128

Journal article

Davies JC, Gill D, Griesenbach U, Voase N, Davies G, Higgins T, Innes JA, Boyd C, Porteous D, Hyde S, Alton EWet al., 2009, EVALUATION OF SAFETY AND GENE EXPRESSION WITH A SINGLE DOSE OF PGM169/GL67A ADMINISTERED TO THE NOSE AND LUNG OF INDIVIDUALS WITH CF: THE UK CF GENE THERAPY CONSORTIUM "PILOT STUDY", PEDIATRIC PULMONOLOGY, Pages: 305-306, ISSN: 8755-6863

Journal article

McBain SC, Griesenbach U, Xenariou S, Keramane A, Batich CD, Alton EWFW, Dobson Jet al., 2008, Magnetic nanoparticles as gene delivery agents: enhanced transfection in the presence of oscillating magnet arrays, NANOTECHNOLOGY, Vol: 19, ISSN: 0957-4484

Journal article

Griesenbach U, Smith SN, Farley R, Singh C, Alton EWFWet al., 2008, Validation of nasal potential difference measurements in gut-corrected CF knockout mice, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 39, Pages: 490-496, ISSN: 1044-1549

Journal article

Griesenbach U, Vicente CC, Green A-M, Cheng SH, Pringle IA, Hyde SC, Gill DR, McLachlan G, Collie D, Alton EWet al., 2008, Secreted gaussia luciferase is a sensitive reporter of gene transfer in the sheep lung, 16th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy, Publisher: MARY ANN LIEBERT INC, Pages: 1123-1123, ISSN: 1043-0342

Conference paper

Griesenbach U, Vicente CC, Green A-M, Cheng SH, Scheule RK, Pringle IA, Gill DR, Hyde SC, Alton EWFWet al., 2008, Successful transfection of human air liquid interface cultures in vivo with the non-viral gene transfer agent GL67A, 16th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy, Publisher: MARY ANN LIEBERT INC, Pages: 1155-1156, ISSN: 1043-0342

Conference paper

Larsen MDB, Griesenbach U, Alton EWFW, 2008, Tight junction openers increase non-viral gene transfer to the airway epithelium in vivo, 16th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy, Publisher: MARY ANN LIEBERT INC, Pages: 1125-1125, ISSN: 1043-0342

Conference paper

Griesenbach U, Munkonge FM, Sumner-Jones S, Holder E, Smith SN, Boyd AC, Gill DR, Hyde SC, Porteous D, Alton EWFWet al., 2008, Assessment of CFTR function after gene transfer in vitro and in vivo., Methods in molecular biology (Clifton, N.J.), Vol: 433, Pages: 229-242, ISSN: 1064-3745

Cystic fibrosis (CF) a monogenic lethal disease and, therefore, ideally suited for the development of gene therapy. The first clinical trials were carried out shortly after cloning the CF gene in 1989. Since then, 25 trials have been carried out. Proof of principle for low-level airway gene transfer was established in most, but not all, trials. It is currently unclear whether current gene transfer efficiency will lead to improvements in clinically relevant endpoints such as inflammation or infection. In addition to addressing this important question, we and others are further improving airway gene transfer, by modifying existing and developing new gene transfer agents. Here, we describe pre-clinical methods related to assessing correction of the CF chloride transport defect.

Journal article

Hilliard TN, Zhu J, Farley R, Escudero-Garcia S, Wainwright BJ, Jeffery PK, Griesenbach U, Bush A, Davies JC, Alton EWFWet al., 2008, Nasal abnormalities in cystic fibrosis mice independent of infection and inflammation, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 39, Pages: 19-25, ISSN: 1044-1549

Journal article

Hyde SC, Pringle IA, Abdullah S, Lawton AE, Davies LA, Varathalingam A, Nunez-Alonso G, Green A-M, Bazzani RP, Sumner-Jones SG, Chan M, Li H, Yew NS, Cheng SH, Boyd AC, Davies JC, Griesenbach U, Porteous DJ, Sheppard DN, Munkonge FM, Alton EWFW, Gill DRet al., 2008, CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression, NATURE BIOTECHNOLOGY, Vol: 26, Pages: 549-551, ISSN: 1087-0156

Journal article

Griesenbach U, Meng C, Farley R, Cheng SH, Scheule RK, Davies MH, Wolstenholme-Hogg PC, ten Hove W, van der Hoeven P, Sinn PL, McCray PB, Inoue M, Geddes DM, Hasegawa M, Frankel G, Wiles S, Alton EWFWet al., 2008, <i>In vivo</i> imaging of gene transfer to the respiratory tract, BIOMATERIALS, Vol: 29, Pages: 1533-1540, ISSN: 0142-9612

Journal article

Mitomo K, Inoue M, Iwasaki H, Tabata T-A, Yoshizaki M, Nagashima N, Washizawa K-T, Fujikawa S, Akiba E, Geddes DM, Griesenbach U, Alton EWFW, Hasegawa Met al., 2008, Detection of clustered GFP positive cells transduced by lentiviral vector pseudotyped sendai virus envelopes in mouse nasal epithelium, 13th Annual Meeting of the Japan-Society-of-Gene-Therapy, Publisher: JOHN WILEY & SONS LTD, Pages: 445-445, ISSN: 1099-498X

Conference paper

Mitomo K, Griesenbach U, Inoue M, Washizawa K, Fujikawa S, Iwasaki H, Somerton L, Farley R, Singh C, Hasegawa M, Alton EWFWet al., 2008, Potential airway stem/progenitor cell integration after transduction with a lentiviral vector pseudotyped with Sendai virus envelope proteins, 5th Annual Conference of the British-Society-for-Gene-Therapy, Publisher: MARY ANN LIEBERT INC, Pages: 404-404, ISSN: 1043-0342

Conference paper

Davidson H, Wilson A, Gray RD, Horsley A, Pringle I, McLachlan G, Gibson J, Holder E, Jones L, Doherty A, Coles R, Sumner-Jones S, Wasowicz M, Manvell M, Griesenbach U, Hyde SC, Gill DR, Davies J, Collie DDS, Alton E, Porteous DJ, Boyd ACet al., 2008, Development of an immunocytochemical assay to detect human CFTR expression following gene therapy, 5th Annual Conference of the British-Society-for-Gene-Therapy, Publisher: MARY ANN LIEBERT INC, Pages: 416-416, ISSN: 1043-0342

Conference paper

Larsen MDB, Griesenbach U, Goussard S, Gruenert DC, Geddes DM, Scheule RK, Cheng SH, Courvalin P, Grillot-Courvalin C, Alton EWFWet al., 2008, Bactofection of lung epithelial cells <i>in vitro</i> and <i>in vivo</i> using a genetically modified <i>Escherichia coli</i>, GENE THERAPY, Vol: 15, Pages: 434-442, ISSN: 0969-7128

Journal article

Rakonczay Z, Hegyi P, Hasegawa M, Inoue M, You J, Iida A, Ignath I, Alton EWFW, Griesenbach U, Ovari G, Vag J, Da Paula AC, Crawford RM, Varga G, Amaral MD, Mehta A, Lonovics J, Argent BE, Gray MAet al., 2008, CFTR gene transfer to human cystic fibrosis pancreatic duct cells using a sendai virus vector, JOURNAL OF CELLULAR PHYSIOLOGY, Vol: 214, Pages: 442-455, ISSN: 0021-9541

Journal article

Griesenbach U, Munkonge FM, Sumner-Jones S, Holder E, Smith SN, Boyd AC, Gill DR, Hyde SC, Porteous D, Alton EWFW, UK Cystic Fibrosis Gene Therapy Consortiumet al., 2008, Assessment of CFTR function after gene transfer in vitro and in vivo., Methods Mol Biol, Vol: 433, Pages: 229-242, ISSN: 1064-3745

Cystic fibrosis (CF) a monogenic lethal disease and, therefore, ideally suited for the development of gene therapy. The first clinical trials were carried out shortly after cloning the CF gene in 1989. Since then, 25 trials have been carried out. Proof of principle for low-level airway gene transfer was established in most, but not all, trials. It is currently unclear whether current gene transfer efficiency will lead to improvements in clinically relevant endpoints such as inflammation or infection. In addition to addressing this important question, we and others are further improving airway gene transfer, by modifying existing and developing new gene transfer agents. Here, we describe pre-clinical methods related to assessing correction of the CF chloride transport defect.

Journal article

Ban H, Inoue M, Griesenbach U, Munkonge F, Chan M, Iida A, Alton E, Hasegawa Met al., 2007, Expression and maturation of Sendai virus vector-derived CFTR protein: functional and biochemical evidence using a GFP-CFTR fusion protein, GENE THERAPY, Vol: 14, Pages: 1688-1694, ISSN: 0969-7128

Journal article

Alexander BL, Ali RR, Alton EWFW, Bainbridge JW, Braun S, Cheng SH, Flotte TR, Gaspar HB, Grez M, Griesenbach U, Kaplitt MG, Ott MG, Seger R, Simons M, Thrasher AJ, Thrasher AZ, Herttuala SYet al., 2007, Progress and prospects: gene therapy clinical trials (part 1) (vol 14, pg 1439, 2007), GENE THERAPY, Vol: 14, Pages: 1754-1754, ISSN: 0969-7128

Journal article

Griesenbach U, Jeswiet SB, Larsen MDB, Bakar Y, Voase NWG, Gammie FM, Mullard KE, Geddes DM, Davies JC, Alton EWFW, Marriott C, Gray R, Horsley A, Imrie M, Dewar M, Greening AP, Innes Aet al., 2007, UK cf gene therapy consortium tracking study: Change in sputum properties in response to IV antibiotics, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A30-A30, ISSN: 0040-6376

Conference paper

Larsen MDB, Griesenbach U, Goussard S, Geddes DM, Grillot-Courvalin C, Alton EWFWet al., 2007, Bactofection into airway epithelial cells in vitro and in vivo using a genetically modified Escherichia coli, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A105-A105, ISSN: 0040-6376

Conference paper

Xenariou S, Griesenbach U, Liang HD, Zhu J, Farley R, Somerton L, Singh C, Jeffery PK, Blomley M, Alton Eet al., 2007, Assessing ultrasound as a method to enhance non-viral gene transfer to the lung, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A105-A105, ISSN: 0040-6376

Conference paper

Alton E, Ferrari S, Griesenbach U, 2007, Progress and prospects: Gene therapy clinical trials (part 2), GENE THERAPY, Vol: 14, Pages: 1555-1563, ISSN: 0969-7128

Journal article

Ferrari S, Griesenbach U, Iida A, Farley R, Wright AM, Zhu J, Munkonge FM, Smith SN, You J, Ban H, Inoue M, Chan M, Singh C, Verdon B, Argent BE, Wainwright B, Jeffery PK, Geddes DM, Porteous DJ, Hyde SC, Gray MA, Hasegawa M, Alton EWFWet al., 2007, Sendai virus-mediated CFTR gene transfer to the airway epithelium, GENE THERAPY, Vol: 14, Pages: 1371-1379, ISSN: 0969-7128

Journal article

Alton E, 2007, Progress and prospects: Gene therapy clinical trials (part 1), GENE THERAPY, Vol: 14, Pages: 1439-1447, ISSN: 0969-7128

Journal article

Xenariou S, Griesenbach U, Liang H-D, Zhu J, Farley R, Somerton L, Singh C, Jeffery PK, Ferrari S, Scheule RK, Cheng SH, Geddes DM, Blomley M, Alton EWFWet al., 2007, Use of ultrasound to enhance nonviral lung gene transfer in vivo, GENE THERAPY, Vol: 14, Pages: 768-774, ISSN: 0969-7128

Journal article

McLachlan G, Baker A, Tennant P, Gordon C, Vrettou C, Renwick L, Blundell R, Cheng SH, Scheule RK, Davies L, Painter H, Coles RL, Lawton AE, Marriott C, Gill DR, Hyde SC, Griesenbach U, Alton EWFW, Boyd AC, Porteous DJ, Collie DDSet al., 2007, Optimizing aerosol gene delivery and expression in the ovine lung, MOLECULAR THERAPY, Vol: 15, Pages: 348-354, ISSN: 1525-0016

Journal article

Gray RD, Horsley A, Macleod K, Imrie M, Dewar M, Voase N, Donovan J, Hyde S, Gill D, Griesenbach U, Davies JC, Alton E, Boyd AC, Porteous D, Cunningham S, Innes JA, Greening APet al., 2007, UKCF gene therapy consortium tracking study: Sputum and serum calprotectin are useful novel measurements in CF exacerbation, PEDIATRIC PULMONOLOGY, Pages: 338-338, ISSN: 8755-6863

Journal article

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