Publications
297 results found
Griesenbach U, Meng C, Farley R, et al., 2009, The role of doxorubicin in non-viral gene transfer in the lung, BIOMATERIALS, Vol: 30, Pages: 1971-1977, ISSN: 0142-9612
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- Citations: 11
Griesenbach U, Alton EWFW, 2009, Gene transfer to the lung: Lessons learned from more than 2 decades of CF gene therapy, ADVANCED DRUG DELIVERY REVIEWS, Vol: 61, Pages: 128-139, ISSN: 0169-409X
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- Citations: 116
Griesenbach U, Alton EWFW, 2009, Cystic fibrosis Ferreting with fibroblasts for cystic fibrosis, GENE THERAPY, Vol: 16, Pages: 1-2, ISSN: 0969-7128
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- Citations: 1
Davies JC, Gill D, Griesenbach U, et al., 2009, EVALUATION OF SAFETY AND GENE EXPRESSION WITH A SINGLE DOSE OF PGM169/GL67A ADMINISTERED TO THE NOSE AND LUNG OF INDIVIDUALS WITH CF: THE UK CF GENE THERAPY CONSORTIUM "PILOT STUDY", PEDIATRIC PULMONOLOGY, Pages: 305-306, ISSN: 8755-6863
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- Citations: 1
McBain SC, Griesenbach U, Xenariou S, et al., 2008, Magnetic nanoparticles as gene delivery agents: enhanced transfection in the presence of oscillating magnet arrays, NANOTECHNOLOGY, Vol: 19, ISSN: 0957-4484
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- Citations: 101
Griesenbach U, Smith SN, Farley R, et al., 2008, Validation of nasal potential difference measurements in gut-corrected CF knockout mice, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 39, Pages: 490-496, ISSN: 1044-1549
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- Citations: 20
Griesenbach U, Vicente CC, Green A-M, et al., 2008, Secreted gaussia luciferase is a sensitive reporter of gene transfer in the sheep lung, 16th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy, Publisher: MARY ANN LIEBERT INC, Pages: 1123-1123, ISSN: 1043-0342
Griesenbach U, Vicente CC, Green A-M, et al., 2008, Successful transfection of human air liquid interface cultures in vivo with the non-viral gene transfer agent GL67A, 16th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy, Publisher: MARY ANN LIEBERT INC, Pages: 1155-1156, ISSN: 1043-0342
Larsen MDB, Griesenbach U, Alton EWFW, 2008, Tight junction openers increase non-viral gene transfer to the airway epithelium in vivo, 16th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy, Publisher: MARY ANN LIEBERT INC, Pages: 1125-1125, ISSN: 1043-0342
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- Citations: 1
Griesenbach U, Munkonge FM, Sumner-Jones S, et al., 2008, Assessment of CFTR function after gene transfer in vitro and in vivo., Methods in molecular biology (Clifton, N.J.), Vol: 433, Pages: 229-242, ISSN: 1064-3745
Cystic fibrosis (CF) a monogenic lethal disease and, therefore, ideally suited for the development of gene therapy. The first clinical trials were carried out shortly after cloning the CF gene in 1989. Since then, 25 trials have been carried out. Proof of principle for low-level airway gene transfer was established in most, but not all, trials. It is currently unclear whether current gene transfer efficiency will lead to improvements in clinically relevant endpoints such as inflammation or infection. In addition to addressing this important question, we and others are further improving airway gene transfer, by modifying existing and developing new gene transfer agents. Here, we describe pre-clinical methods related to assessing correction of the CF chloride transport defect.
Hilliard TN, Zhu J, Farley R, et al., 2008, Nasal abnormalities in cystic fibrosis mice independent of infection and inflammation, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 39, Pages: 19-25, ISSN: 1044-1549
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- Citations: 12
Hyde SC, Pringle IA, Abdullah S, et al., 2008, CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression, NATURE BIOTECHNOLOGY, Vol: 26, Pages: 549-551, ISSN: 1087-0156
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- Citations: 240
Griesenbach U, Meng C, Farley R, et al., 2008, <i>In vivo</i> imaging of gene transfer to the respiratory tract, BIOMATERIALS, Vol: 29, Pages: 1533-1540, ISSN: 0142-9612
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- Citations: 13
Mitomo K, Inoue M, Iwasaki H, et al., 2008, Detection of clustered GFP positive cells transduced by lentiviral vector pseudotyped sendai virus envelopes in mouse nasal epithelium, 13th Annual Meeting of the Japan-Society-of-Gene-Therapy, Publisher: JOHN WILEY & SONS LTD, Pages: 445-445, ISSN: 1099-498X
Mitomo K, Griesenbach U, Inoue M, et al., 2008, Potential airway stem/progenitor cell integration after transduction with a lentiviral vector pseudotyped with Sendai virus envelope proteins, 5th Annual Conference of the British-Society-for-Gene-Therapy, Publisher: MARY ANN LIEBERT INC, Pages: 404-404, ISSN: 1043-0342
Davidson H, Wilson A, Gray RD, et al., 2008, Development of an immunocytochemical assay to detect human CFTR expression following gene therapy, 5th Annual Conference of the British-Society-for-Gene-Therapy, Publisher: MARY ANN LIEBERT INC, Pages: 416-416, ISSN: 1043-0342
Larsen MDB, Griesenbach U, Goussard S, et al., 2008, Bactofection of lung epithelial cells <i>in vitro</i> and <i>in vivo</i> using a genetically modified <i>Escherichia coli</i>, GENE THERAPY, Vol: 15, Pages: 434-442, ISSN: 0969-7128
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- Citations: 23
Rakonczay Z, Hegyi P, Hasegawa M, et al., 2008, CFTR gene transfer to human cystic fibrosis pancreatic duct cells using a sendai virus vector, JOURNAL OF CELLULAR PHYSIOLOGY, Vol: 214, Pages: 442-455, ISSN: 0021-9541
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- Citations: 31
Griesenbach U, Munkonge FM, Sumner-Jones S, et al., 2008, Assessment of CFTR function after gene transfer in vitro and in vivo., Methods Mol Biol, Vol: 433, Pages: 229-242, ISSN: 1064-3745
Cystic fibrosis (CF) a monogenic lethal disease and, therefore, ideally suited for the development of gene therapy. The first clinical trials were carried out shortly after cloning the CF gene in 1989. Since then, 25 trials have been carried out. Proof of principle for low-level airway gene transfer was established in most, but not all, trials. It is currently unclear whether current gene transfer efficiency will lead to improvements in clinically relevant endpoints such as inflammation or infection. In addition to addressing this important question, we and others are further improving airway gene transfer, by modifying existing and developing new gene transfer agents. Here, we describe pre-clinical methods related to assessing correction of the CF chloride transport defect.
Ban H, Inoue M, Griesenbach U, et al., 2007, Expression and maturation of Sendai virus vector-derived CFTR protein: functional and biochemical evidence using a GFP-CFTR fusion protein, GENE THERAPY, Vol: 14, Pages: 1688-1694, ISSN: 0969-7128
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- Citations: 17
Alexander BL, Ali RR, Alton EWFW, et al., 2007, Progress and prospects: gene therapy clinical trials (part 1) (vol 14, pg 1439, 2007), GENE THERAPY, Vol: 14, Pages: 1754-1754, ISSN: 0969-7128
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- Citations: 6
Griesenbach U, Jeswiet SB, Larsen MDB, et al., 2007, UK cf gene therapy consortium tracking study: Change in sputum properties in response to IV antibiotics, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A30-A30, ISSN: 0040-6376
Larsen MDB, Griesenbach U, Goussard S, et al., 2007, Bactofection into airway epithelial cells in vitro and in vivo using a genetically modified Escherichia coli, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A105-A105, ISSN: 0040-6376
Xenariou S, Griesenbach U, Liang HD, et al., 2007, Assessing ultrasound as a method to enhance non-viral gene transfer to the lung, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A105-A105, ISSN: 0040-6376
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- Citations: 1
Alton E, Ferrari S, Griesenbach U, 2007, Progress and prospects: Gene therapy clinical trials (part 2), GENE THERAPY, Vol: 14, Pages: 1555-1563, ISSN: 0969-7128
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- Citations: 62
Ferrari S, Griesenbach U, Iida A, et al., 2007, Sendai virus-mediated CFTR gene transfer to the airway epithelium, GENE THERAPY, Vol: 14, Pages: 1371-1379, ISSN: 0969-7128
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- Citations: 49
Alton E, 2007, Progress and prospects: Gene therapy clinical trials (part 1), GENE THERAPY, Vol: 14, Pages: 1439-1447, ISSN: 0969-7128
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- Citations: 73
Xenariou S, Griesenbach U, Liang H-D, et al., 2007, Use of ultrasound to enhance nonviral lung gene transfer in vivo, GENE THERAPY, Vol: 14, Pages: 768-774, ISSN: 0969-7128
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- Citations: 59
McLachlan G, Baker A, Tennant P, et al., 2007, Optimizing aerosol gene delivery and expression in the ovine lung, MOLECULAR THERAPY, Vol: 15, Pages: 348-354, ISSN: 1525-0016
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- Citations: 43
Gray RD, Horsley A, Macleod K, et al., 2007, UKCF gene therapy consortium tracking study: Sputum and serum calprotectin are useful novel measurements in CF exacerbation, PEDIATRIC PULMONOLOGY, Pages: 338-338, ISSN: 8755-6863
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