Publications
36 results found
Shah UV, Olusanmi D, Narang AS, et al., 2014, Effect of crystal habits on the surface energy and cohesion of crystalline powders, International Journal of Pharmaceutics, Vol: 472, Pages: 140-147, ISSN: 1873-3476
The role of surface properties, influenced by particle processing, in particle–particle interactions (powder cohesion) is investigated in this study. Wetting behaviour of mefenamic acid was found to be anisotropic by sessile drop contact angle measurements on macroscopic (>1 cm) single crystals, with variations in contact angle of water from 56.3° to 92.0°. This is attributed to variations in surface chemical functionality at specific facets, and confirmed using X-ray photoelectron spectroscopy (XPS). Using a finite dilution inverse gas chromatography (FD-IGC) approach, the surface energy heterogeneity of powders was determined. The surface energy profile of different mefenamic acid crystal habits was directly related to the relative exposure of different crystal facets. Cohesion, determined by a uniaxial compression test, was also found to relate to surface energy of the powders. By employing a surface modification (silanisation) approach, the contribution from crystal shape from surface area and surface energy was decoupled. By “normalising” contribution from surface energy and surface area, needle shaped crystals were found to be ∼2.5× more cohesive compared to elongated plates or hexagonal cuboid shapes crystals.
Olusanmi D, Jayawickrama D, Bu D, et al., 2014, A control strategy for bioavailability enhancement by size reduction: Effect of micronization conditions on the bulk, surface and blending characteristics of an active pharmaceutical ingredient, POWDER TECHNOLOGY, Vol: 258, Pages: 222-233, ISSN: 0032-5910
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- Citations: 33
Khoo JY, Shah UV, Schaepertoens M, et al., 2013, Process-induced phase transformation of carbamazepine dihydrate to its polymorphic anhydrates, POWDER TECHNOLOGY, Vol: 236, Pages: 114-121, ISSN: 0032-5910
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- Citations: 21
Delmas T, Shah UV, Roberts MM, et al., 2013, Crystallisation of the orthorhombic form of acetaminophen: Combined effect of surface topography and chemistry, POWDER TECHNOLOGY, Vol: 236, Pages: 24-29, ISSN: 0032-5910
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- Citations: 16
Shah UV, Allenby MC, Williams DR, et al., 2012, Crystallization of Proteins at Ultralow Supersaturations Using Novel Three-Dimensional Nanotemplates, CRYSTAL GROWTH & DESIGN, Vol: 12, Pages: 1772-1777, ISSN: 1528-7483
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- Citations: 31
Shah UV, Williams DR, Heng JYY, 2012, Selective Crystallization of Proteins Using Engineered Nanonucleants, CRYSTAL GROWTH & DESIGN, Vol: 12, Pages: 1362-1369, ISSN: 1528-7483
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- Citations: 48
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