Imperial College London
Alternate

ProfessorVaniaBraga

Faculty of Medicine, National Heart & Lung Institute

Professor of Cellular Signalling
 
 
 
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Contact

 

+44 (0)20 7594 3233v.braga

 
 
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Location

 

Office no. 105Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{McCormack:2013:10.1242/jcs.097923,
author = {McCormack, J and Welsh, NJ and Braga, VMM},
doi = {10.1242/jcs.097923},
journal = {JOURNAL OF CELL SCIENCE},
pages = {379--391},
title = {Cycling around cell-cell adhesion with Rho GTPase regulators},
url = {http://dx.doi.org/10.1242/jcs.097923},
volume = {126},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The formation and stability of epithelial adhesive systems, such as adherens junctions, desmosomes and tight junctions, rely on a number of cellular processes that ensure a dynamic interaction with the cortical cytoskeleton, and appropriate delivery and turnover of receptors at the surface. Unique signalling pathways must be coordinated to allow the coexistence of distinct adhesive systems at discrete sub-domains along junctions and the specific properties they confer to epithelial cells. Rho, Rac and Cdc42 are members of the Rho small GTPase family, and are well-known regulators of cell–cell adhesion. The spatio-temporal control of small GTPase activation drives specific intracellular processes to enable the hierarchical assembly, morphology and maturation of cell–cell contacts. Here, we discuss the small GTPase regulators that control the precise amplitude and duration of the levels of active Rho at cell–cell contacts, and the mechanisms that tailor the output of Rho signalling to a particular cellular event. Interestingly, the functional interaction is reciprocal; Rho regulators drive the maturation of cell–cell contacts, whereas junctions can also modulate the localisation and activity of Rho regulators to operate in diverse processes in the epithelial differentiation programme.
AU  - McCormack,J
AU  - Welsh,NJ
AU  - Braga,VMM
DO  - 10.1242/jcs.097923
EP  - 391
PY  - 2013///
SN  - 0021-9533
SP  - 379
TI  - Cycling around cell-cell adhesion with Rho GTPase regulators
T2  - JOURNAL OF CELL SCIENCE
UR  - http://dx.doi.org/10.1242/jcs.097923
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000316945600002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/62125
VL  - 126
ER  -
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