Imperial College London
Portrait Picture

ProfessorVictoriaCornelius

Faculty of Medicine, School of Public Health

Professor in Medical Statistics and Trials Methodology
 
 
 
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Contact

 

+44 (0)20 7594 1218v.cornelius

 
 
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Assistant

 

Mrs Ranjit Rayat +44 (0)20 7594 3445

 
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Location

 

111Stadium HouseWhite City Campus

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Summary

 

Publications

Publication Type
Year
to

217 results found

Uddin M, Lau LC, Seumois G, Vijayanand P, Staples KJ, Bagmane D, Cornelius V, Dorinsky P, Davies DE, Djukanović Ret al., 2013, EGF-Induced Bronchial Epithelial Cells Drive Neutrophil Chemotactic and Anti-Apoptotic Activity in Asthma, PLOS One, Vol: 8, ISSN: 1932-6203

Chronic damage and repair of the bronchial epithelium are features of asthma. We have previously reported that ex vivo stimulation of normal bronchial epithelial cells with epidermal growth factor (EGF), a key factor of epithelial repair, enhances the mechanisms of neutrophil accumulation, thereby promoting neutrophil defences during acute injury but potentially enhancing inflammation in chronic airway diseases. We have now sought to (i) determine whether this EGF-dependent pro-neutrophil activity is increased in asthma, where EGF and its epithelial receptor are over-expressed, and (ii) elucidate some of the mechanisms underlying this asthmatic epithelial-neutrophil interaction. Primary bronchial epithelial cells (PBEC) from healthy subjects, mild asthmatics and moderate-to-severe asthmatics (Mod/Sev) were stimulated with EGF, a model that mimics a repairing epithelium. Conditioned culture media (EGF-CM) were assessed for neutrophil chemotactic and anti-apoptotic activities and inflammatory mediator production. EGF induced the epithelium to produce soluble mediators with neutrophil chemotactic (p<0.001) and pro-survival (p = 0.021) activities which were related to the clinical severity of asthma (trend p = 0.010 and p = 0.009, respectively). This was associated with enhanced IL-6, IL-8, GM-CSF and TNF-α release, and cytokine-neutralising experiments using EGF-CM from Mod/Sev asthmatics demonstrated a role for GM-CSF in neutrophil survival (p<0.001). Pre-treatment of neutrophils with specific inhibitors of the myeloid-restricted class I phosphatidylinositol-3-OH kinase (PI(3)K) isoforms showed that the EGF-CM from Mod/Sev asthmatics depended on the γ (p<0.021) but not δ isoforms, while neutrophil survival required multiple class I PI(3)Ks. The EGF-induced chemotactic, but not pro-survival activity, involved RhoA signaling in neutrophils (p = 0.012). EGF whose activity is upregulated in asthma induces ex vivo the epithelium from asthmatic pa

Journal article

Ali K, Grigoratos D, Cornelius V, Davenport M, Nicolaides K, Greenough Aet al., 2013, Outcome of CDH infants following fetoscopic tracheal occlusion - influence of premature delivery, JOURNAL OF PEDIATRIC SURGERY, Vol: 48, Pages: 1831-1836, ISSN: 0022-3468

Journal article

Buggy Y, Cornelius V, Fogg C, Kasliwal R, Layton D, Shakir SAWet al., 2013, Neuropsychiatric Events with Varenicline: a Modified Prescription-Event Monitoring Study in General Practice in England, DRUG SAFETY, Vol: 36, Pages: 521-531, ISSN: 0114-5916

Journal article

Moyses HE, Johnson MJ, Leaf AA, Cornelius VRet al., 2013, Early parenteral nutrition and growth outcomes in preterm infants: a systematic review and meta-analysis, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 97, Pages: 816-826, ISSN: 0002-9165

Journal article

Hazell L, Cornelius V, Hannaford P, Shakir S, Avery AJet al., 2013, How Do Patients Contribute to Signal Detection? A Retrospective Analysis of Spontaneous Reporting of Adverse Drug Reactions in the UK's Yellow Card Scheme, DRUG SAFETY, Vol: 36, Pages: 199-206, ISSN: 0114-5916

Journal article

Cornelius VR, Sauzet O, Williams JE, Ayis S, Farquhar-Smith P, Ross JR, Branford RA, Peacock JLet al., 2013, Adverse event reporting in randomised controlled trials of neuropathic pain: Considerations for future practice, PAIN, Vol: 154, Pages: 213-220, ISSN: 0304-3959

Journal article

Chalkidou A, Landau DB, Odell EW, Cornelius VR, O'Doherty MJ, Marsden PKet al., 2012, Correlation between Ki-67 immunohistochemistry and 18F-Fluorothymidine uptake in patients with cancer: A systematic review and meta-analysis, EUROPEAN JOURNAL OF CANCER, Vol: 48, Pages: 3499-3513, ISSN: 0959-8049

Journal article

Shankar-Hari M, Singer M, Cornelius V, Sanderson B, Gordon A, Terblanche M, Rowan K, Beale R, Spencer Jet al., 2012, LOW IMMUNOGLOBULIN I; LEVELS AT ADMISSION REDUCES THE ODDS FOR 28 DAY MORTALITY COMPARED TO NORMAL LEVELS: PROSPECTIVE COHORT STUDY IN SEVERE SEPSIS, INTENSIVE CARE MEDICINE, Vol: 38, Pages: S54-S54, ISSN: 0342-4642

Journal article

Burns EE, Boulton MG, Cluett E, Cornelius VR, Smith LAet al., 2012, Characteristics, Interventions, and Outcomes of Women Who Used a Birthing Pool: A Prospective Observational Study, BIRTH-ISSUES IN PERINATAL CARE, Vol: 39, Pages: 192-202, ISSN: 0730-7659

Journal article

Wiskin AE, Owens DR, Cornelius VR, Wootton SA, Beattie RMet al., 2012, Paediatric nutrition risk scores in clinical practice: children with inflammatory bowel disease, JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 25, Pages: 319-322, ISSN: 0952-3871

Journal article

Wiskin AE, Wootton SA, Cornelius VR, Afzal NA, Elia M, Beattie RMet al., 2012, No Relation Between Disease Activity Measured by Multiple Methods and REE in Childhood Crohn Disease, JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, Vol: 54, Pages: 271-276, ISSN: 0277-2116

Journal article

Cornelius VR, Sauzet O, Evans SJW, 2012, A Signal Detection Method to Detect Adverse Drug Reactions Using a Parametric Time-to-Event Model in Simulated Cohort Data, DRUG SAFETY, Vol: 35, Pages: 599-610, ISSN: 0114-5916

Journal article

Connolly A, Taylor D, Sparshatt A, Cornelius Vet al., 2011, Antipsychotic prescribing in Black and White hospitalised patients, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 25, Pages: 704-709, ISSN: 0269-8811

Journal article

Wiskin AE, Wootton SA, Hunt TM, Cornelius VR, Afzal NA, Jackson AA, Beattie RMet al., 2011, Body composition in childhood inflammatory bowel disease, CLINICAL NUTRITION, Vol: 30, Pages: 112-115, ISSN: 0261-5614

Journal article

Buggy Y, Cornelius V, Wilton L, Shakir SAWet al., 2011, Risk of Depressive Episodes with Rimonabant A Before and After Modified Prescription Event Monitoring Study Conducted in England, DRUG SAFETY, Vol: 34, Pages: 501-509, ISSN: 0114-5916

Journal article

Moyses HE, Johnson MJ, Cornelius V, Leaf AAet al., 2011, Is there any benefit to starting total parenteral nutrition early in very low birth weight infants? A systematic review, Publisher: CAMBRIDGE UNIV PRESS, Pages: E259-E259, ISSN: 0029-6651

Conference paper

Vlckova V, Cornelius V, Kasliwal R, Wilton L, Shakir Set al., 2010, Hypoglycaemia with pioglitazone: analysis of data from the Prescription-Event Monitoring study, JOURNAL OF EVALUATION IN CLINICAL PRACTICE, Vol: 16, Pages: 1124-1128, ISSN: 1356-1294

Journal article

Hazell L, Cornelius V, Shakir S, Avery Aet al., 2010, Patient Reporting of ADRs in the UK: How Do Patient Reports Affect Potential Signals Generated by Healthcare Professionals?, Publisher: WILEY-BLACKWELL, Pages: S321-S321, ISSN: 1053-8569

Conference paper

Uddin M, Nong G, Ward J, Seumois G, Prince LR, Wilson SJ, Cornelius V, Dent G, Djukanovic Ret al., 2010, Prosurvival activity for airway neutrophils in severe asthma, THORAX, Vol: 65, Pages: 684-689, ISSN: 0040-6376

Journal article

Hazell L, Cornelius V, Shakir S, Avery Aet al., 2010, Reporting of Adverse Drug Reactions in the UK: Potential Signals Generated by Patients Compared to Healthcare Professionals, Publisher: WILEY-BLACKWELL, Pages: S97-S98, ISSN: 1053-8569

Conference paper

Marshall V, Behr E, Cornelius V, Shakir S, Camm Jet al., 2010, Cohort Description of the Drug-Induced Arrhythmia Risk Evaluation (DARE) Study, Publisher: WILEY-BLACKWELL, Pages: S33-S33, ISSN: 1053-8569

Conference paper

Taylor D, Cornelius V, 2010, Risperidone long-acting injection: factors associated with changes in bed stay and hospitalisation in a 3-year naturalistic follow-up, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 24, Pages: 995-999, ISSN: 0269-8811

Journal article

Smith LA, Cornelius VR, Plummer CJ, Levitt G, Verrill M, Canney P, Jones Aet al., 2010, Cardiotoxicity of anthracycline agents for the treatment of cancer: systematic review and meta-analysis of randomised controlled trials, BMC Cancer, Vol: 10, ISSN: 1471-2407

BACKGROUND: We conducted a systematic review and meta-analysis to clarify the risk of early and late cardiotoxicity of anthracycline agents in patients treated for breast or ovarian cancer, lymphoma, myeloma or sarcoma. METHODS: Randomized controlled trials were sought using comprehensive searches of electronic databases in June 2008. Reference lists of retrieved articles were also scanned for additional articles. Outcomes investigated were early or late clinical and sub-clinical cardiotoxicity. Trial quality was assessed, and data were pooled through meta-analysis where appropriate. RESULTS: Fifty-five published RCTs were included; the majority were on women with advanced breast cancer. A significantly greater risk of clinical cardiotoxicity was found with anthracycline compared with non-anthracycline regimens (OR 5.43 95% confidence interval: 2.34, 12.62), anthracycline versus mitoxantrone (OR 2.88 95% confidence interval: 1.29, 6.44), and bolus versus continuous anthracycline infusions (OR 4.13 95% confidence interval: 1.75, 9.72). Risk of clinical cardiotoxicity was significantly lower with epirubicin versus doxorubicin (OR 0.39 95% confidence interval: 0.20, 0.78), liposomal versus non-liposomal doxorubicin (OR 0.18 95% confidence interval: 0.08, 0.38) and with a concomitant cardioprotective agent (OR 0.21 95% confidence interval: 0.13, 0.33). No statistical heterogeneity was found for these pooled analyses. A similar pattern of results were found for subclinical cardiotoxicity; with risk significantly greater with anthracycline containing regimens and bolus administration; and significantly lower risk with epirubicin, liposomal doxorubicin versus doxorubicin but not epirubicin, and with concomitant use of a cardioprotective agent. Low to moderate statistical heterogeneity was found for two of the five pooled analyses, perhaps due to the different criteria used for reduction in Left Ventricular Ejection Fraction. Meta-analyses of any cardiotoxicity (clinical an

Journal article

Smith LA, Cornelius VR, Azorin JM, Perugi G, Vieta E, Young AH, Bowden CLet al., 2010, Valproate for the treatment of acute bipolar depression: Systematic review and meta-analysis, JOURNAL OF AFFECTIVE DISORDERS, Vol: 122, Pages: 1-9, ISSN: 0165-0327

Journal article

Cornelius V, Buggy Y, Layton D, Fogg C, Shakir Set al., 2010, Signal Detection using Time to Event Analysis: Varenicline and Neuropsychiatric Events, 10th International-Society-of-Pharmacovigilance Annual Meeting on Pharmacovigilance in the Global Village, Publisher: S INT LTD, Pages: 904-905, ISSN: 0114-5916

Conference paper

Owens DR, Wiskin AE, Cornelius VR, Wootton SA, Beattie RMet al., 2010, Concurrent validity of nutrition risk scores in paediatric inflammatory bowel disease, Publisher: CAMBRIDGE UNIV PRESS, Pages: E537-E537, ISSN: 0029-6651

Conference paper

Cornelius VR, Perrio MJ, Shakir SAW, Smith LAet al., 2009, Systematic reviews of adverse effects of drug interventions: a survey of their conduct and reporting quality, PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, Vol: 18, Pages: 1223-1231, ISSN: 1053-8569

Journal article

Taylor D, Fischetti C, Sparshatt A, Thomas A, Bishara D, Cornelius Vet al., 2009, Risperidone long-acting injection: a 6-year mirror-image study of healthcare resource use, ACTA PSYCHIATRICA SCANDINAVICA, Vol: 120, Pages: 97-101, ISSN: 0001-690X

Journal article

Hazell L, Cornelius V, Wilton L, Shakir Set al., 2009, Mortality Due to Ischaemic Heart Disease in 15,659 Patients Prescribed Vardenafil in General Practice in England (2005): Results from a Prescription-Event Monitoring (PEM) Study, Publisher: JOHN WILEY & SONS LTD, Pages: S168-S169, ISSN: 1053-8569

Conference paper

Vlckova V, Cornelius V, Kasliwal R, Wilton L, Shakir SAWet al., 2009, Hypoglycaemia with rosiglitazone, pioglitazone, nateglinide, and repaglinide: results from prescription-event monitoring studies, Publisher: SPRINGER, Pages: 255-255, ISSN: 0928-1231

Conference paper

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