Imperial College London
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ProfessorVictoriaCornelius

Faculty of Medicine, School of Public Health

Professor in Medical Statistics and Trials Methodology
 
 
 
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Contact

 

+44 (0)20 7594 1218v.cornelius

 
 
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Assistant

 

Mrs Ranjit Rayat +44 (0)20 7594 3445

 
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Location

 

111Stadium HouseWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mace:2022:10.1177/02698811211058973,
author = {Mace, S and Dzahini, O and Cornelius, V and Langerman, H and Oloyede, E and Taylor, D},
doi = {10.1177/02698811211058973},
journal = {Journal of Psychopharmacology},
pages = {232--237},
title = {Incident infection during the first year of treatment - a comparison of clozapine and paliperidone palmitate long-acting injection},
url = {http://dx.doi.org/10.1177/02698811211058973},
volume = {36},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:To examine the risk of infection in patients prescribed clozapine compared with patients prescribed paliperidone palmitate long-acting injection (PPLAI).Method:A retrospective, 1-year, cohort study conducted on events occurring in eligible patients beginning treatment for the first time with clozapine or PPLAI between June 2017 and June 2019 in a UK mental health trust providing in-patient and out-patient services.Results:The study included 64 patients starting clozapine and 120 patients starting PPLAI. Incidence of infection was greater in clozapine starters than in PPLAI starters (28% vs 6%; p = 0.001; adjusted odds ratio 5.82 (95% confidence interval (CI) = 2.15–15.76, p = 0.001). Infectious episodes in clozapine patients were not related to changes in neutrophil counts. Incident infection in the clozapine group was highest in the first 3 months of treatment. The most commonly reported infection in the clozapine group was chest infection; however, the majority of infections were non-chest-related.Conclusion:Patients starting clozapine showed a substantially increased likelihood of infection compared with patients starting PPLAI.
AU  - Mace,S
AU  - Dzahini,O
AU  - Cornelius,V
AU  - Langerman,H
AU  - Oloyede,E
AU  - Taylor,D
DO  - 10.1177/02698811211058973
EP  - 237
PY  - 2022///
SN  - 0269-8811
SP  - 232
TI  - Incident infection during the first year of treatment - a comparison of clozapine and paliperidone palmitate long-acting injection
T2  - Journal of Psychopharmacology
UR  - http://dx.doi.org/10.1177/02698811211058973
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000740854800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://journals.sagepub.com/doi/10.1177/02698811211058973
VL  - 36
ER  -
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