Imperial College London
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DrValeriaGarbin

Faculty of Engineering, Department of Chemical Engineering

Visiting Professor
 
 
 
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Contact

 

v.garbin

 
 
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Assistant

 

Ms Sevgi Thompson +44 (0)20 7594 1478

 
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Location

 

ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lazarus:2017:10.1121/1.5010170,
author = {Lazarus, C and Pouliopoulos, AN and Tinguely, M and Garbin, V and Choi, JJ},
doi = {10.1121/1.5010170},
journal = {Journal of the Acoustical Society of America},
pages = {3135--3146},
title = {Clustering dynamics of microbubbles exposed to low-pressure 1-MHz ultrasound},
url = {http://dx.doi.org/10.1121/1.5010170},
volume = {142},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Ultrasound-driven microbubbles have been used in therapeutic applications to deliver drugs acrosscapillaries and into cells or to dissolve blood clots. Yet the performance and safety of these applica-tions have been difficult to control. Microbubbles exposed to ultrasound not only volumetricallyoscillate, but also move due to acoustic radiation, or Bjerknes, forces. The purpose of this work wasto understand the extent to which microbubbles moved and clustered due to secondary Bjerknesforces.  A  microbubble  population  was  exposed  to  a  1-MHz  ultrasound  pulse  with  apeak-rarefactional pressure of 50–100 kPa and a pulse length of 20 ms. Microbubbles exposed tolow-pressure therapeutic ultrasound were observed to cluster at clustering rates of 0.01–0.02 micro-bubbles per duration (in ms) per initial average inter-bubble distance (inlm), resulting in 1 to 3clustered microbubbles per initial average inter-bubble distance (inlm). Higher pressures causedfaster clustering rates and a larger number of clustered microbubbles. Experimental data revealedclustering time scales, cluster localizations, and cluster sizes that were in reasonable agreementwith simulations using a time-averaged model at low pressures. This study demonstrates that clus-tering of microbubbles occurs within a few milliseconds and is likely to influence the distributionof stimuli produced in therapeutic applications.
AU  - Lazarus,C
AU  - Pouliopoulos,AN
AU  - Tinguely,M
AU  - Garbin,V
AU  - Choi,JJ
DO  - 10.1121/1.5010170
EP  - 3146
PY  - 2017///
SN  - 0001-4966
SP  - 3135
TI  - Clustering dynamics of microbubbles exposed to low-pressure 1-MHz ultrasound
T2  - Journal of the Acoustical Society of America
UR  - http://dx.doi.org/10.1121/1.5010170
UR  - http://hdl.handle.net/10044/1/54283
VL  - 142
ER  -
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