Imperial College London
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DrVerityLeeson

Faculty of Medicine, Department of Brain Sciences

Clinical Trials Manager
 
 
 
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Contact

 

v.leeson

 
 
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Location

 

Clinical Trials OfficeCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Crawford:2018:10.1176/appi.ajp.2018.17091006,
author = {Crawford, MJ and Sanatinia, R and Barrett, B and Cunningham, G and Dale, O and Gunguli, P and Lawrence-Smith, G and Leeson, V and Lmeonsky, F and Lykomitrou, G and Montgomery, A and Morriss, R and Munjiza, J and Paton, C and Skorodzien, I and Singh, V and Tan, W and Tyrer, P and Reilly, JG and LABILE, study team},
doi = {10.1176/appi.ajp.2018.17091006},
journal = {American Journal of Psychiatry},
pages = {756--764},
title = {The clinical effectiveness and cost effectiveness of lamotrigine for people with borderline personality disorder: a randomized, placebo-controlled trial},
url = {http://dx.doi.org/10.1176/appi.ajp.2018.17091006},
volume = {175},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objectives:To examine whether lamotrigine is a clinically effective and cost-effective treatment for people with borderline personality disorder. Method:Multicentre, double-blind, placebo-controlled randomized trial.  Between July 2013 to November 2016, we recruited 276 people aged 18 or over, who met diagnostic criteria for borderline personality disorder. We excluded those with co-existing bipolar affective disorder or psychosis, those already taking a mood stabiliser, and women at risk of pregnancy. We randomly allocated participants on a 1:1 ratio to up to 400mg of lamotrigine per day or an inert placebo using a remote web-based randomization service. The primary outcome was total score on the Zanarini Rating scale for Borderline Personality Disorder (ZAN-BPD) at 52 weeks. Secondary outcomes included depressive symptoms, deliberate self-harm, social functioning, health-related quality of life, resource use and costs, side effects of treatment and adverse events. Results:195 (70.6%) participants were followed up at 52 weeks, at which point 49 (36%) of those prescribed lamotrigine and 58 (42%) of those prescribed placebo were taking it. Mean total ZAN-BPD score was 11.3 (SD = 6.6) among those randomized to lamotrigine and 11.5 (SD = 7.7) among those randomized to placebo (adjusted difference in means = 0.1, 95% C.I = -1.8 to 2.0, p=0.91). There was no evidence of any differences in secondary outcomes. Costs of direct care for those prescribed lamotrigine were similar to those prescribed placebo.  Conclusions:Treating people with borderline personality disorder with lamotrigine is not a clinically effective or cost-effective use of resources.
AU  - Crawford,MJ
AU  - Sanatinia,R
AU  - Barrett,B
AU  - Cunningham,G
AU  - Dale,O
AU  - Gunguli,P
AU  - Lawrence-Smith,G
AU  - Leeson,V
AU  - Lmeonsky,F
AU  - Lykomitrou,G
AU  - Montgomery,A
AU  - Morriss,R
AU  - Munjiza,J
AU  - Paton,C
AU  - Skorodzien,I
AU  - Singh,V
AU  - Tan,W
AU  - Tyrer,P
AU  - Reilly,JG
AU  - LABILE,study team
DO  - 10.1176/appi.ajp.2018.17091006
EP  - 764
PY  - 2018///
SN  - 0002-953X
SP  - 756
TI  - The clinical effectiveness and cost effectiveness of lamotrigine for people with borderline personality disorder: a randomized, placebo-controlled trial
T2  - American Journal of Psychiatry
UR  - http://dx.doi.org/10.1176/appi.ajp.2018.17091006
UR  - http://hdl.handle.net/10044/1/57265
VL  - 175
ER  -
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