Imperial College London
Alternate

DrVincenzoLibri

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 1677v.libri

 
 
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Location

 

NIHR Imperial Clinical Research FacilityICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Devanand:2010:10.1177/0891988710363715,
author = {Devanand, DP and Mikhno, A and Pelton, GH and Cuasay, K and Pradhaban, G and Dileep, Kumar JS and Upton, N and Lai, R and Gunn, RN and Libri, V and Liu, X and van, Heertum R and Mann, JJ and Parsey, RV},
doi = {10.1177/0891988710363715},
journal = {J Geriatr Psychiatry Neurol},
pages = {185--198},
title = {Pittsburgh compound B (11C-PIB) and fluorodeoxyglucose (18 F-FDG) PET in patients with Alzheimer disease, mild cognitive impairment, and healthy controls},
url = {http://dx.doi.org/10.1177/0891988710363715},
volume = {23},
year = {2010}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Amyloid load in the brain using Pittsburgh compound B ((11)C-PIB) positron emission tomography (PET) and cerebral glucose metabolism using fluorodeoxyglucose ((18)F-FDG) PET were evaluated in patients with mild Alzheimer disease (AD, n = 18), mild cognitive impairment (MCI, n = 24), and controls (CTR, n = 18). ( 11)C-PIB binding potential (BP(ND)) was higher in prefrontal cortex, cingulate, parietal cortex, and precuneus in AD compared to CTR or MCI and in prefrontal cortex for MCI compared to CTR. For (18)F-FDG, regional cerebral metabolic rate for glucose (rCMRGlu) was decreased in precuneus and parietal cortex in AD compared to CTR and MCI, with no MCI-CTR differences. For the AD-CTR comparison, precuneus BP(ND) area under the receiver operating characteristic (ROC) curve (AUC) was 0.938 and parietal cortex rCMRGlu AUC was 0.915; for the combination, AUC was 0.989. ( 11)C-PIB PET BP(ND) clearly distinguished diagnostic groups and combined with (18)F-FDG PET rCMRGlu, this effect was stronger. These PET techniques provide complementary information in strongly distinguishing diagnostic groups in cross-sectional comparisons that need testing in longitudinal studies.
AU  - Devanand,DP
AU  - Mikhno,A
AU  - Pelton,GH
AU  - Cuasay,K
AU  - Pradhaban,G
AU  - Dileep,Kumar JS
AU  - Upton,N
AU  - Lai,R
AU  - Gunn,RN
AU  - Libri,V
AU  - Liu,X
AU  - van,Heertum R
AU  - Mann,JJ
AU  - Parsey,RV
DO  - 10.1177/0891988710363715
EP  - 198
PY  - 2010///
SN  - 0891-9887
SP  - 185
TI  - Pittsburgh compound B (11C-PIB) and fluorodeoxyglucose (18 F-FDG) PET in patients with Alzheimer disease, mild cognitive impairment, and healthy controls
T2  - J Geriatr Psychiatry Neurol
UR  - http://dx.doi.org/10.1177/0891988710363715
UR  - http://www.ncbi.nlm.nih.gov/pubmed/20430977
VL  - 23
ER  -
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