Imperial College London
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DrVictoriaMale

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer in Reproductive Immunology
 
 
 
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Contact

 

v.male

 
 
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Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Male:2017:10.1055/s-0037-1603946,
author = {Male, V and Stegmann, KA and Easom, NJ and Maini, MK},
doi = {10.1055/s-0037-1603946},
journal = {Seminars in Liver Disease},
pages = {198--209},
title = {Natural killer cells in liver disease},
url = {http://dx.doi.org/10.1055/s-0037-1603946},
volume = {37},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Natural killer (NK) cells comprise one of the most abundant immune cell populations in human liver and the nature and functions of these cells have been a focus of recent interest. Here, we consider the possible roles of NK cells in diverse liver diseases, concentrating on data from patient studies. NK cells can be protective, killing virally infected and cancerous cells in the liver and limiting fibrosis by eliminating hepatic stellate cells. However, they can also be deleterious, contributing to pathology in viral hepatitis by killing hepatocytes and downregulating virus-specific T-cell responses. It has recently emerged that a large fraction of hepatic NK cells constitute a distinct liver-resident subset and we highlight the need to distinguish between circulating and liver-resident NK cells in future studies. There is also a need for further investigation into how NK cells are influenced by the liver microenvironment and what scope there is to harness their immunotherapeutic potential.
AU  - Male,V
AU  - Stegmann,KA
AU  - Easom,NJ
AU  - Maini,MK
DO  - 10.1055/s-0037-1603946
EP  - 209
PY  - 2017///
SN  - 0272-8087
SP  - 198
TI  - Natural killer cells in liver disease
T2  - Seminars in Liver Disease
UR  - http://dx.doi.org/10.1055/s-0037-1603946
UR  - https://www.ncbi.nlm.nih.gov/pubmed/28847031
UR  - http://hdl.handle.net/10044/1/69891
VL  - 37
ER  -
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