Imperial College London
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DrVictoriaMale

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer in Reproductive Immunology
 
 
 
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Contact

 

v.male

 
 
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Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Cuff:2019:10.1101/583575,
author = {Cuff, A and Perchet, T and Dertschnig, S and Golub, R and Male, V},
doi = {10.1101/583575},
publisher = {bioRxiv},
title = {Tbet promotes NK cell bone marrow egress via CXCR6 expression},
url = {http://dx.doi.org/10.1101/583575},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - Tbet-deficient mice have reduced NK cells in blood and spleen, but increased NK cells in bone marrow and lymph nodes, a phenotype that is thought to be due to a defect in S1PR5-mediated migration. Here, we revisit the role of Tbet in NK cell bone marrow egress. We definitively show that the accumulation of NK cells in the bone marrow of Tbet-deficient (Tbx21 −/− ) animals occurs because of a cell-intrinsic migration defect. We identify a profile of gene expression, co-ordinated by Tbet, which affects the localisation of NK cells in the bone marrow. The most underexpressed gene in the absence of Tbet was Cxcr6, and we confirmed that CXCR6 protein was also not expressed in Tbet-deficient NK cells. Cxcr6-expressing ILC progenitors and immature NK cells accumulate in the bone marrow of CXCR6-deficient mice. This suggests that CXCR6 is among the mediators of migration, controlled by Tbet, that work together to coordinate NK cell bone marrow egress. Understanding NK cell bone marrow egress will become increasingly important as we move into an era in which NK cell immunotherapies are being developed.
AU  - Cuff,A
AU  - Perchet,T
AU  - Dertschnig,S
AU  - Golub,R
AU  - Male,V
DO  - 10.1101/583575
PB  - bioRxiv
PY  - 2019///
TI  - Tbet promotes NK cell bone marrow egress via CXCR6 expression
UR  - http://dx.doi.org/10.1101/583575
UR  - https://www.biorxiv.org/content/10.1101/583575v1
UR  - http://hdl.handle.net/10044/1/72990
ER  -
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