Imperial College London
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DrVictoriaMale

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer in Reproductive Immunology
 
 
 
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Contact

 

v.male

 
 
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Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Monin:2020:10.1111/imm.13136,
author = {Monin, L and Whettlock, EM and Male, V},
doi = {10.1111/imm.13136},
journal = {Immunology},
pages = {106--115},
title = {Immune responses in the human female reproductive tract},
url = {http://dx.doi.org/10.1111/imm.13136},
volume = {160},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Mucosal surfaces are key interfaces between the host and its environment, but also constitute ports of entry for numerous pathogens. The gut and lung mucosae act as points of nutrient and gas exchange, respectively, but the physiological purpose of the female reproductive tract (FRT) is to allow implantation and development of the fetus. Our understanding of immune responses in the FRT has traditionally lagged behind our grasp of the situation at other mucosal sites, but recently reproductive immunologists have begun to make rapid progress in this challenging area. Here, we review current knowledge of immune responses in the human FRT and their heterogeneity within and between compartments. In the commensal-rich vagina, the immune system must allow the growth of beneficial microbes, whereas the key challenge in the uterus is allowing the growth of the semi-allogeneic fetus. In both compartments, these objectives must be balanced with the need to eliminate pathogens. Our developing understanding of immune responses in the FRT will help us develop interventions to prevent the spread of sexually transmitted diseases and to improve outcomes of pregnancy for mothers and babies.
AU  - Monin,L
AU  - Whettlock,EM
AU  - Male,V
DO  - 10.1111/imm.13136
EP  - 115
PY  - 2020///
SN  - 0019-2805
SP  - 106
TI  - Immune responses in the human female reproductive tract
T2  - Immunology
UR  - http://dx.doi.org/10.1111/imm.13136
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31630394
UR  - https://onlinelibrary.wiley.com/doi/full/10.1111/imm.13136
UR  - http://hdl.handle.net/10044/1/76190
VL  - 160
ER  -
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