Imperial College London
Dr Vias Markides

DrViasMarkides

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7351 8619v.markides

 
 
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Assistant

 

Dr Tom Wong +44 (0)20 7351 8619

 
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Location

 

Chelsea WingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jarman:2018:10.1186/s12872-018-0946-6,
author = {Jarman, JWE and Hussain, W and Wong, T and Markides, V and March, J and Goldstein, L and Liao, R and Kalsekar, I and Chitnis, A and Khanna, R},
doi = {10.1186/s12872-018-0946-6},
journal = {BMC Cardiovascular Disorders},
title = {Resource use and clinical outcomes in patients with atrial fibrillation with ablation versus antiarrhythmic drug treatment},
url = {http://dx.doi.org/10.1186/s12872-018-0946-6},
volume = {18},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThe objective of our study was to compare resource use and clinical outcomes among atrial fibrillation (AF) patients who underwent catheter ablation versus antiarrhythmic drug (AAD) treatment.MethodsA retrospective cohort design using the Clinical Practice Research Data-Hospital Episode Statistics linkage data from England (2008–2013) was used. Patients undergoing catheter ablation treatment for AF were indexed to the date of first procedure. AAD patients with at least two different AAD drugs were indexed to the first fill of the second AAD. Patients were matched using 1:1 propensity matching. Primary endpoints including inpatient and outpatient visits were compared between ablation and AAD cohorts in the 4 months-1 year period after index. Secondary endpoints including heart failure, stroke, cardioversion, mortality, and a composite outcome were compared for the 4 months-3 years post-index period in the two groups. Cox-proportional hazards models were estimated for clinical outcomes comparison.ResultsA total of 558 patients were matched in the two groups for resource utilization comparison. The average number of cardiovascular (CV)-related outpatient visits in the 4–12 months post-index period were significantly lower in the ablation group versus the AAD group (1.76 vs 3.57, p < .0001). There was no significant difference in all-cause and CV-related inpatient visits and all-cause outpatient visits among the two groups. For secondary endpoints comparison, 615 matched patients in each group emerged. Ablation patients had 38% lower risk of heart failure (hazard ratio [HR] 0.62, p = 0.0318), 50% lower risk of mortality (HR 0.50, p = 0.0082), and 43% lower risk of experiencing a composite outcome (HR 0.57, p = 0.0009) as compared to AAD treatment cohort.ConclusionAF ablation was associated with significantly lower CV-related outpatient visits, and lower risk of heart failure and mortality v
AU  - Jarman,JWE
AU  - Hussain,W
AU  - Wong,T
AU  - Markides,V
AU  - March,J
AU  - Goldstein,L
AU  - Liao,R
AU  - Kalsekar,I
AU  - Chitnis,A
AU  - Khanna,R
DO  - 10.1186/s12872-018-0946-6
PY  - 2018///
SN  - 1471-2261
TI  - Resource use and clinical outcomes in patients with atrial fibrillation with ablation versus antiarrhythmic drug treatment
T2  - BMC Cardiovascular Disorders
UR  - http://dx.doi.org/10.1186/s12872-018-0946-6
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000449714700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/65811
VL  - 18
ER  -
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