Summary
Unravelling the molecular mechanisms that impose regional identity in the developing nervous system
As an embryo develops, a wide variety of cell types form along the length of the body. This diversity is dependent on position: some cell types form exclusively in the head, while others form in the trunk. Our ambition is to understand how this organisation is established and maintained during development, by studying the transcriptional control mechanisms that govern cell fate decisions.
Publications
Journals
Semprich C, Davidson L, Torres AA, et al., 2022, ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the polycomb repressive complex, Plos Biology, Vol:20, ISSN:1544-9173
Blassberg R, Patel H, Watson T, et al., 2022, Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation, Nature Cell Biology, Vol:24, ISSN:1465-7392, Pages:633-+
Needham J, Metzis V, 2022, Heads or tails: making the spinal cord, Developmental Biology, Vol:485, ISSN:0012-1606, Pages:80-92
Binagui-Casas A, Dias A, Guillot C, et al., 2021, Building consensus in neuromesodermal research: Current advances and future biomedical perspectives, Current Opinion in Cell Biology, Vol:73, ISSN:0955-0674, Pages:133-140