Unravelling the molecular mechanisms that impose regional identity in the developing nervous system
As an embryo develops, a wide variety of cell types form along the length of the body. This diversity is dependent on position: some cell types form exclusively in the head, while others form in the trunk. Our ambition is to understand how this organisation is established and maintained during development, by studying the transcriptional control mechanisms that govern cell fate decisions.
et al., 2021, Precision of Tissue Patterning is Controlled by Dynamical Properties of Gene Regulatory Networks., Development
et al., 2020, Sox2 levels configure the WNT response of epiblast progenitors responsible for vertebrate body formation
et al., 2019, Precision of Tissue Patterning is Controlled by Dynamical Properties of Gene Regulatory Networks
et al., 2019, ERK1/2 signalling dynamics promote neural differentiation by regulating the polycomb repressive complex
et al., 2019, c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4(+) T cells (vol 19, pg 497, 2018), Nature Immunology, Vol:20, ISSN:1529-2908, Pages:374-374