Imperial College London


Faculty of MedicineInstitute of Clinical Sciences

Sir Henry Dale Research Fellow



v.metzis Website




4023CRB (Clinical Research Building)Hammersmith Campus





Unravelling the molecular mechanisms that impose regional identity in the developing nervous system

As an embryo develops, a wide variety of cell types form along the length of the body. This diversity is dependent on position: some cell types form exclusively in the head, while others form in the trunk. Our ambition is to understand how this organisation is established and maintained during development, by studying the transcriptional control mechanisms that govern cell fate decisions.

Mouse embryo tilescan



Exelby K, Herrera-Delgado E, Perez LG, et al., 2021, Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks, Development, Vol:148, ISSN:0950-1991

Blassberg R, Patel H, Watson T, et al., 2020, Sox2 levels configure the WNT response of epiblast progenitors responsible for vertebrate body formation

Exelby K, Herrera-Delgado E, Perez LG, et al., 2019, Precision of Tissue Patterning is Controlled by Dynamical Properties of Gene Regulatory Networks

Semprich CI, Metzis V, Patel H, et al., 2019, ERK1/2 signalling dynamics promote neural differentiation by regulating the polycomb repressive complex

Gabrysova L, Alvarez-Martinez M, Luisier R, et al., 2019, c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4(+) T cells (vol 19, pg 497, 2018), Nature Immunology, Vol:20, ISSN:1529-2908, Pages:374-374

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