Summary
Dr Reebye is involved in the development of therapeutic gain of function studies using novel RNA activation strategies. His work involves close collaboration with private biotechnology and international academic institutions both in the US and Asia. These versatile and powerful new tools for gene activation has shown an impact in experimental regenerative medicine by redirecting adult stem cells towards a surrogate insulin secreting phenotype and also in oncology by improving liver function and loss of tumour burden in cirrhotic models.
Publications
Journals
Andrikakou P, Reebye V, Vasconcelos D, et al., 2022, Enhancing SIRT1 Gene Expression Using Small Activating RNAs: A Novel Approach for Reversing Metabolic Syndrome, Nucleic Acid Therapeutics, Vol:32, ISSN:2159-3337, Pages:486-496
Conference
Przybilla MJ, Reebye V, Vanezis K, et al., 2023, Transcriptional Upregulation of α-L-iduronidase Utilizing Small-Activating RNA Following Bone Marrow Transplant in a Murine Model of Hurler Syndrome, CELL PRESS, Pages:189-190, ISSN:1525-0016
Plummer R, Sodergren M, Ryan B, et al., 2023, MTL-CEBPA in combination with pembrolizumab converts an immune desert to an inflamed TME in solid tumors resistant to checkpoint blockade, 114th Annual Meeting of the American Association for Cancer Research (AACR), AMER ASSOC CANCER RESEARCH, ISSN:0008-5472
Habib N, Reebye V, Vanezis K, et al., 2023, Drugging transcription factors with small activating RNAs: A novel approach for enhancing bone marrow therapy for monogenic rare diseases, 19th Annual World Symposium, ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages:55-55, ISSN:1096-7192
Przybilla MJ, Reebye V, Vanezis K, et al., 2023, Treating murine Hurler syndrome utilizing small-activating RNA following bone marrow transplant, 19th Annual World Symposium, ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages:107-107, ISSN:1096-7192