Imperial College London
Portrait Picture

DrVictoriaSalem

Faculty of Engineering, Department of Bioengineering

Clinical Senior Lecturer in Diabetes and Endocrinology
 
 
 
//

Contact

 

v.salem

 
 
//

Location

 

Commonwealth BuildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Akalestou:2021:10.1038/s41467-021-25423-8,
author = {Akalestou, E and Suba, K and Lopez-Noriega, L and Georgiadou, E and Chabosseau, P and Gallie, A and Wretlind, A and Quigley, C and Leclerc, I and Salem, V and Rutter, GA},
doi = {10.1038/s41467-021-25423-8},
journal = {Nature Communications},
pages = {1--13},
title = {Intravital imaging of islet Ca2+ dynamics reveals enhanced beta cell connectivity after bariatric surgery in mice},
url = {http://dx.doi.org/10.1038/s41467-021-25423-8},
volume = {12},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Bariatric surgery improves both insulin sensitivity and secretion and can induce diabetes remission. However, the mechanisms and time courses of these changes, particularly the impact on β cell function, are difficult to monitor directly. In this study, we investigated the effect of Vertical Sleeve Gastrectomy (VSG) on β cell function in vivo by imaging Ca2+ dynamics in islets engrafted into the anterior eye chamber. Mirroring its clinical utility, VSG in mice results in significantly improved glucose tolerance, and enhanced insulin secretion. We reveal that these benefits are underpinned by augmented β cell function and coordinated activity across the islet. These effects involve changes in circulating GLP-1 levels which may act both directly and indirectly on the β cell, in the latter case through changes in body weight. Thus, bariatric surgery leads to time-dependent increases in β cell function and intra-islet connectivity which are likely to contribute to diabetes remission.
AU  - Akalestou,E
AU  - Suba,K
AU  - Lopez-Noriega,L
AU  - Georgiadou,E
AU  - Chabosseau,P
AU  - Gallie,A
AU  - Wretlind,A
AU  - Quigley,C
AU  - Leclerc,I
AU  - Salem,V
AU  - Rutter,GA
DO  - 10.1038/s41467-021-25423-8
EP  - 13
PY  - 2021///
SN  - 2041-1723
SP  - 1
TI  - Intravital imaging of islet Ca2+ dynamics reveals enhanced beta cell connectivity after bariatric surgery in mice
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-021-25423-8
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000691020900017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41467-021-25423-8
UR  - http://hdl.handle.net/10044/1/94117
VL  - 12
ER  -
Download