Imperial College London
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DrVictoriaSalem

Faculty of Engineering, Department of Bioengineering

Clinical Senior Lecturer in Diabetes and Endocrinology
 
 
 
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v.salem

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Salem:2016:10.1111/dom.12585,
author = {Salem, V and Izzi-Engbeaya, C and Coello, C and Thomas, DB and Chambers, ES and Comninos, A and Buckley, A and Win, Z and Al-Nahhas, A and Rabiner, EA and Gunn, RN and Bloom, SR and Tan, TM and Dhillo, WS and Budge, H and Symonds, ME},
doi = {10.1111/dom.12585},
journal = {Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics},
pages = {72--81},
title = {Glucagon increases energy expenditure independently of brown adipose tissue activation in humans},
url = {http://dx.doi.org/10.1111/dom.12585},
volume = {18},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Aims: To investigate, for a given energy expenditure (EE) rise, the differential effects of glucagon infusion and cold exposure on brown adipose tissue (BAT) activation in humans.Methods: Indirect calorimetry and supraclavicular thermography was performed in 11 healthy male volunteers before and after: cold exposure; glucagon infusion (at 23 °C); and vehicle infusion (at 23 °C). All volunteers underwent ¹F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/CT scanning with cold exposure. Subjects with cold-induced BAT activation on ¹F-FDG PET/CT (n = 8) underwent a randomly allocated second ¹F-FDG PET/CT scan (at 23 °C), either with glucagon infusion (n = 4) or vehicle infusion (n = 4).Results: We observed that EE increased by 14% after cold exposure and by 15% after glucagon infusion (50 ng/kg/min; p < 0.05 vs control for both). Cold exposure produced an increase in neck temperature (+0.44 °C; p < 0.001 vs control), but glucagon infusion did not alter neck temperature. In subjects with a cold-induced increase in the metabolic activity of supraclavicular BAT on ¹F-FDG PET/CT, a significant rise in the metabolic activity of BAT after glucagon infusion was not detected. Cold exposure increased sympathetic activation, as measured by circulating norepinephrine levels, but glucagon infusion did not.Conclusions: Glucagon increases EE by a similar magnitude compared with cold activation, but independently of BAT thermogenesis. This finding is of importance for the development of safe treatments for obesity through upregulation of EE.
AU  - Salem,V
AU  - Izzi-Engbeaya,C
AU  - Coello,C
AU  - Thomas,DB
AU  - Chambers,ES
AU  - Comninos,A
AU  - Buckley,A
AU  - Win,Z
AU  - Al-Nahhas,A
AU  - Rabiner,EA
AU  - Gunn,RN
AU  - Bloom,SR
AU  - Tan,TM
AU  - Dhillo,WS
AU  - Budge,H
AU  - Symonds,ME
DO  - 10.1111/dom.12585
EP  - 81
PY  - 2016///
SN  - 1462-8902
SP  - 72
TI  - Glucagon increases energy expenditure independently of brown adipose tissue activation in humans
T2  - Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics
UR  - http://dx.doi.org/10.1111/dom.12585
UR  - https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.12585
UR  - http://hdl.handle.net/10044/1/27759
VL  - 18
ER  -
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