Summary
Dr Vanessa Sancho-Shimizu is a research fellow in the section of paediatrics, division of infectious diseases. She is currently working on understanding the Mendelian predisposition to rare childhood infections specifically: identifying genes underlying childhood (1) herpes simplex encephalitis (HSE), (2) severe viral infections, and (3) invasive meningococcal disease (IMD).
Vanessa Sancho-Shimizu obtained her BSc degree from McGill University in Montreal, Canada. Her PhD project, based in the Centre for the study of Host Resistance to Infectious Disease, focused on investigating the genetics underlying host resistance to Salmonella infection in wild-derived mice. She moved to Paris, France following her PhD, to start her postdoctoral research in the laboratory of Human Genetics of Infectious Disease in the Necker Enfants Malades Hospital at Universite Paris Descartes, developping an expertise in investigating Mendelian predisposition to childhood herpes simplex encephalitis (HSE), and TLR3-antiviral IFN pathways. This led to the identification of human TRIF deficiency as novel genetic aetiology of HSE. She came to Imperial College in 2012 as a Marie Curie research fellow working with Prof M Levin in the section of Paediatrics, continuing her work on the genetic predisposition of childhood HSE in collaboration with her previous lab lead by Prof JL Casanova, but has also extended the search of Mendelian defects to other clinical disease phenotypes including severe childhood viral infections and invasive meningococcal disease (IMD). She has started her own group in 2014 with a career development award from the Medical Research Foundation, within the sections of Virology and Paediatrics.
Vanessa Sancho-Shimizu has been a Marie Cuire fellow from 2008-2010 and 2012-2014. She is currently funded by the Medical Research Foundation.
https://www.youtube.com/watch?v=WKTFVRNhdzg
Publications
Journals
Drake TM, Riad AM, Fairfield CJ, et al.Drake TM, Riad AM, Fairfield CJ, Egan C, Knight SR, Pius R, Hardwick HE, Norman L, Shaw CA, McLean KA, Thompson AAR, Ho A, Swann OV, Sullivan M, Soares F, Holden KA, Merson L, Plotkin D, Sigfrid L, de Silva TI, Girvan M, Jackson C, Russell CD, Dunning J, Solomon T, Carson G, Olliaro P, Nguyen-Van-Tam JS, Turtle L, Docherty AB, Openshaw PJ, Baillie JK, Harrison EM, Semple MG, ISARIC4C investigators close, 2021, Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study, The Lancet, Vol:398, ISSN:0140-6736, Pages:223-237
ISARIC Clinical Characterisation Group, 2021, COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study, Infection: Journal of Infectious Disease, ISSN:0300-8126
Sancho-Shimizu V, Brodin P, Cobat A, et al.Sancho-Shimizu V, Brodin P, Cobat A, Biggs CM, Toubiana J, Lucas CL, Henrickson SE, Belot A, Haddad E, Beland K, Pujol A, Schlüter A, Planas-Serra L, Aguilera-Albesa S, Valencia-Ramos J, Rodríguez-Palmero A, Gut M, Rivière JG, Colobran R, Soler-Palacin P, Rodriguez-Gallego C, Perez De Diego R, Flores C, Alsina L, Blazquez-Gamero D, Jordan I, Keles S, Emiroglu M, Akcan OM, Alkan G, Aytekin SE, Gul Y, Tüter Öz ŞK, Bozdemir SE, Bayhan GI, Yüksek SK, Parlakay AÖ, Gülhan B, Yahşi A, Kilic AO, Karbuz A, Erdeniz EH, Özkan EA, Orbak Z, Aydemir Ş, Celik JB, Kandemir B, Aytekin G, Kapakli H, Yarar V, Yosunkaya A, Vatansev H, Aytekin C, Torun SH, Nepesov S, Coskuner T, Sözeri B, Demirkol YK, Kasapcopur O, Yıldız M, Sevketoglu E, Hatipoğlu N, Özçelik T, Yesilbas O, Gayretli Aydin ZG, Sediva A, Klocperk A, Bloomfield M, Meyts I, Delafontaine S, Haerynck F, Hoste L, Shahrooei M, Marque L, Neves JF, Novelli G, Novelli A, Aiuti A, Casari G, Bousfiha AA, Almuhsen SZ, Sobh A, Gagro A, Bajolle F, Bonnet D, Lebon P, Lei W, Lee D, Seeleuthner Y, Zhang P, Maglorius M, Philippot Q, Pelham S, Bastard P, Zhang Q, Jouanguy E, Puel A, Herberg J, Kuijpers TW, Bellos E, Kaforou M, Menikou S, Pan-Hammarström Q, Hammarström L, Abolhassani H, Bryceson Y, Condino-Neto A, Prando C, Bando SY, Cavalcanti A, Fellay J, Blanchard-Hohner G, Mansouri D, Mahmoudi S, Boyarchuk O, Volokha A, Bondarenko A, Stepanovskiy Y, Mogensen T, van de Beek D, Andreakos E, Papadaki M, Abou Tayoun A, Halwani R, Al-Mulla F, Franco JL, Lau Y-L, Kwan M, Imai K, Okada S, Bolze A, Butte MJ, Hsieh E, Drolet BA, Arkin L, Itan Y, Maniatis T, Arditi M, Cooper M, Schmitt E, Chakravorty S, Anderson MS, Su HC, Notarangelo LD, Tangye SG, Milner JD, Levin M, Abel L, Bogunovic D, Casanova J-L, Zhang S-Y close, 2021, SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?, Journal of Experimental Medicine, Vol:218, ISSN:0022-1007, Pages:1-16
Gupta RK, Harrison EM, Ho A, et al.Gupta RK, Harrison EM, Ho A, Docherty AB, Knight SR, van Smeden M, Abubakar I, Lipman M, Quartagno M, Pius R, Buchan I, Carson G, Drake TM, Dunning J, Fairfield CJ, Gamble C, Green CA, Halpin S, Hardwick HE, Holden KA, Horby PW, Jackson C, Mclean KA, Merson L, Nguyen-Van-Tam JS, Norman L, Olliaro PL, Pritchard MG, Russell CD, Scott-Brown J, Shaw CA, Sheikh A, Solomon T, Sudlow C, Swann OV, Turtle L, Openshaw PJM, Baillie JK, Semple MG, Noursadeghi M, Baillie JK, Semple MG, Openshaw PJM, Carson G, Alex B, Bach B, Barclay WS, Bogaert D, Chand M, Cooke GS, Docherty AB, Dunning J, Filipe ADS, Fletcher T, Green CA, Harrison EM, Hiscox JA, Ho AYW, Horby PW, Ijaz S, Khoo S, Klenerman P, Law A, Lim WS, Mentzer AJ, Merson L, Meynert AM, Noursadeghi M, Moore SC, Palmarini M, Paxton WA, Pollakis G, Price N, Rambaut A, Robertson DL, Russell CD, Sancho-Shimizu V, Scott JT, de Silva T, Sigfrid L, Solomon T, Sriskandan S, Stuart D, Summers C, Tedder RS, Thomson EC, Thompson AAR, Thwaites RS, Turtle LCW, Zambon M, Hardwick H, Donohue C, Lyons R, Griffiths F, Oosthuyzen W, Norman L, Pius R, Drake TM, Fairfield CJ, Knight S, Mclean KA, Murphy D, Shaw CA, Dalton J, Lee J, Plotkin D, Girvan M, Mullaney S, Petersen C, Saviciute E, Roberts S, Harrison J, Marsh L, Connor M, Halpin S, Jackson C, Gamble C, Leeming G, Law A, Wham M, Clohisey S, Hendry R, Scott-Brown J, Greenhalf W, Shaw V, McDonald S, Keating S, Ahmed KA, Armstrong JA, Ashworth M, Asiimwe IG, Bakshi S, Barlow SL, Booth L, Brennan B, Bullock K, Catterall BWA, Clark JJ, Clarke EA, Cole S, Cooper L, Cox H, Davis C, Dincarslan O, Dunn C, Dyer P, Elliott A, Evans A, Finch L, Fisher LWS, Foster T, Garcia-Dorival I, Greenhalf W, Gunning P, Hartley C, Ho A, Jensen RL, Jones CB, Jones TR, Khandaker S, King K, Kiy RT, Koukorava C, Lake A, Lant S, Latawiec D, Lavelle-Langham L, Lefteri D, Lett L, Livoti LA, Mancini M, McDonald S, McEvoy L, McLauchlan J, Metelmann S, Miah NS, Middleton J, Mitchell J, Moore SC, Murphy EG, Penrice-Randal close, 2021, Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study, The Lancet Respiratory Medicine, Vol:9, ISSN:2213-2600, Pages:349-359
Yates T, Zaccardi F, Islam N, et al.Yates T, Zaccardi F, Islam N, Razieh C, Gillies CL, Lawson CA, Chudasama Y, Rowlands A, Davies MJ, Docherty AB, Openshaw PJ, Baillie JK, Semple MG, ISARIC4C investigators, Khunti K close, 2021, Obesity, ethnicity and risk of critical care, mechanical ventilation and mortality in patients admitted to hospital with COVID-19: Analysis of the ISARIC CCP-UK cohort., Obesity (silver Spring, Md.), Vol:29, ISSN:1071-7323, Pages:1223-1230
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