Dr Vanessa Sancho-Shimizu

Faculty of Medicine, Department of Infectious Disease

Lecturer

Contact

Location

309Norfolk PlaceSt Mary's Campus

Summary

Dr Vanessa Sancho-Shimizu is a research fellow in the section of paediatrics, division of infectious diseases. She is currently working on understanding the Mendelian predisposition to rare childhood infections specifically: identifying genes underlying childhood (1) herpes simplex encephalitis (HSE), (2) severe viral infections, and (3) invasive meningococcal disease (IMD).

Vanessa Sancho-Shimizu obtained her BSc degree from McGill University in Montreal, Canada. Her PhD project, based in the Centre for the study of Host Resistance to Infectious Disease, focused on investigating the genetics underlying host resistance to Salmonella infection in wild-derived mice. She moved to Paris, France following her PhD, to start her postdoctoral research in the laboratory of Human Genetics of Infectious Disease in the Necker Enfants Malades Hospital at Universite Paris Descartes, developping an expertise in investigating Mendelian predisposition to childhood herpes simplex encephalitis (HSE), and TLR3-antiviral IFN pathways. This led to the identification of human TRIF deficiency as novel genetic aetiology of HSE. She came to Imperial College in 2012 as a Marie Curie research fellow working with Prof M Levin in the section of Paediatrics, continuing her work on the genetic predisposition of childhood HSE in collaboration with her previous lab lead by Prof JL Casanova, but has also extended the search of Mendelian defects to other clinical disease phenotypes including severe childhood viral infections and invasive meningococcal disease (IMD). She has started her own group in 2014 with a career development award from the Medical Research Foundation, within the sections of Virology and Paediatrics.

Vanessa Sancho-Shimizu has been a Marie Cuire fellow from 2008-2010 and 2012-2014. She is currently funded by the Medical Research Foundation.

https://www.youtube.com/watch?v=WKTFVRNhdzg

Publications

Journals

Zhang Q, Bastard P, Liu Z, et al.Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C, Rosain J, Bilguvar K, Ye J, Bolze A, Bigio B, Yang R, Arias AA, Zhou Q, Zhang Y, Onodi F, Korniotis S, Karpf L, Philippot Q, Chbihi M, Bonnet-Madin L, Dorgham K, Smith N, Schneider WM, Razooky BS, Hoffmann H-H, Michailidis E, Moens L, Han JE, Lorenzo L, Bizien L, Meade P, Neehus A-L, Ugurbil AC, Corneau A, Kerner G, Zhang P, Rapaport F, Seeleuthner Y, Manry J, Masson C, Schmitt Y, Schlüter A, Le Voyer T, Khan T, Li J, Fellay J, Roussel L, Shahrooei M, Alosaimi MF, Mansouri D, Al-Saud H, Al-Mulla F, Almourfi F, Al-Muhsen SZ, Alsohime F, Al Turki S, Hasanato R, van de Beek D, Biondi A, Bettini LR, D'Angio M, Bonfanti P, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Oler AJ, Tompkins MF, Alba C, Vandernoot I, Goffard J-C, Smits G, Migeotte I, Haerynck F, Soler-Palacin P, Martin-Nalda A, Colobran R, Morange P-E, Keles S, Çölkesen F, Ozcelik T, Yasar KK, Senoglu S, Karabela ŞN, Gallego CR, Novelli G, Hraiech S, Tandjaoui-Lambiotte Y, Duval X, Laouénan C, COVID-STORM Clinicians, COVID Clinicians, Imagine COVID Group, French COVID Cohort Study Group, CoV-Contact Cohort, Amsterdam UMC Covid-19, Biobank, COVID Human Genetic Effort, NIAID-USUHS, TAGC COVID Immunity Group, Snow AL, Dalgard CL, Milner J, Vinh DC, Mogensen TH, Marr N, Spaan AN, Boisson B, Boisson-Dupuis S, Bustamante J, Puel A, Ciancanelli M, Meyts I, Maniatis T, Soumelis V, Amara A, Nussenzweig M, García-Sastre A, Krammer F, Pujol A, Duffy D, Lifton R, Zhang S-Y, Gorochov G, Béziat V, Jouanguy E, Sancho-Shimizu V, Rice CM, Abel L, Notarangelo LD, Cobat A, Su HC, Casanova J-L close, 2020, Inborn errors of type I IFN immunity in patients with life-threatening COVID-19, Science, Vol:370, ISSN:0036-8075, Pages:1-16

Nishimura S, Kobayashi Y, Ohnishi H, et al.Nishimura S, Kobayashi Y, Ohnishi H, Moriya K, Tsumura M, Sakata S, Mizoguchi Y, Takada H, Kato Z, Sancho-Shimizu V, Picard C, Irani SR, Ohara O, Casanova J-L, Puel A, Ishikawa N, Okada S, Kobayashi M close, 2020, IRAK4 Deficiency Presenting with Anti-NMDAR Encephalitis and HHV6 Reactivation., J Clin Immunol

Casanova J-L, Su HC, COVID Human Genetic Effort, 2020, A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection., Cell, Vol:181, ISSN:0092-8674, Pages:1194-1199

Hodeib S, Herberg JA, Levin M, et al.Hodeib S, Herberg JA, Levin M, Sancho-Shimizu V close, 2020, Human genetics of meningococcal infections, Human Genetics, Vol:139, ISSN:0340-6717, Pages:961-980

Sancho Shimizu V, 2020, A rare mutation in SPLUNC1 underlies meningococcal disease affecting bacterial adherence and invasion, Clinical Infectious Diseases, Vol:70, ISSN:1058-4838, Pages:2045-2053

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