Imperial College London
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Dr Vanessa Sancho-Shimizu

Faculty of Medicine, Department of Infectious Disease

Reader in Human Genetics of Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3914v.sancho-shimizu

 
 
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Location

 

309Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ahmad:2018:10.3389/fcell.2018.00155,
author = {Ahmad, L and Mostowy, S and Sancho-Shimizu, V},
doi = {10.3389/fcell.2018.00155},
journal = {Frontiers in Cell and Developmental Biology},
title = {Autophagy-Virus Interplay: From Cell Biology to Human Disease},
url = {http://dx.doi.org/10.3389/fcell.2018.00155},
volume = {6},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Autophagy is a highly conserved intracellular degradation process that targets protein aggregates and damaged organelles. Autophagy is also implicated in numerous viral infections, including human immunodeficiency virus-1 (HIV-1), influenza A (IAV) and herpes simplex virus-1 (HSV-1). Depending on the virus, autophagy can restrict or promote viral replication, and play key roles in modulating inflammation and cell survival. In this review, we consider examples of autophagy-virus interplay, highlighting the protective role of autophagy in human infections. We summarize recent discoveries and emerging themes illuminating autophagy’s role in immunity and inflammation upon viral infection. Finally, we discuss future prospects and therapeutic implications, and potential caveats associated with using autophagy to control viral infections in humans.
AU  - Ahmad,L
AU  - Mostowy,S
AU  - Sancho-Shimizu,V
DO  - 10.3389/fcell.2018.00155
PY  - 2018///
SN  - 2296-634X
TI  - Autophagy-Virus Interplay: From Cell Biology to Human Disease
T2  - Frontiers in Cell and Developmental Biology
UR  - http://dx.doi.org/10.3389/fcell.2018.00155
UR  - http://hdl.handle.net/10044/1/64749
VL  - 6
ER  -
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