Imperial College London
Portrait Picture

Dr Vanessa Sancho-Shimizu

Faculty of Medicine, Department of Infectious Disease

Reader in Human Genetics of Infectious Diseases
 
 
 
//

Contact

 

+44 (0)20 7594 3914v.sancho-shimizu

 
 
//

Location

 

309Norfolk PlaceSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Bastard:2020:10.1126/science.abd4585,
author = {Bastard, P and Rosen, LB and Zhang, Q and Michailidis, E and Hoffmann, H-H and Zhang, Y and Dorgham, K and Philippot, Q and Rosain, J and Béziat, V and Manry, J and Shaw, E and Haljasmägi, L and Peterson, P and Lorenzo, L and Bizien, L and Trouillet-Assant, S and Dobbs, K and de, Jesus AA and Belot, A and Kallaste, A and Catherinot, E and Tandjaoui-Lambiotte, Y and Le, Pen J and Kerner, G and Bigio, B and Seeleuthner, Y and Yang, R and Bolze, A and Spaan, AN and Delmonte, OM and Abers, MS and Aiuti, A and Casari, G and Lampasona, V and Piemonti, L and Ciceri, F and Bilguvar, K and Lifton, RP and Vasse, M and Smadja, DM and Migaud, M and Hadjadj, J and Terrier, B and Duffy, D and Quintana-Murci, L and van, de Beek D and Roussel, L and Vinh, DC and Tangye, SG and Haerynck, F and Dalmau, D and Martinez-Picado, J and Brodin, P and Nussenzweig, MC and Boisson-Dupuis, S and Rodríguez-Gallego, C and Vogt, G and Mogensen, TH and Oler, AJ and Gu, J and Burbelo, PD and Cohen, JI and Biondi, A an},
doi = {10.1126/science.abd4585},
journal = {Science},
title = {Autoantibodies against type I IFNs in patients with life-threatening COVID-19},
url = {http://dx.doi.org/10.1126/science.abd4585},
volume = {370},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
AU  - Bastard,P
AU  - Rosen,LB
AU  - Zhang,Q
AU  - Michailidis,E
AU  - Hoffmann,H-H
AU  - Zhang,Y
AU  - Dorgham,K
AU  - Philippot,Q
AU  - Rosain,J
AU  - Béziat,V
AU  - Manry,J
AU  - Shaw,E
AU  - Haljasmägi,L
AU  - Peterson,P
AU  - Lorenzo,L
AU  - Bizien,L
AU  - Trouillet-Assant,S
AU  - Dobbs,K
AU  - de,Jesus AA
AU  - Belot,A
AU  - Kallaste,A
AU  - Catherinot,E
AU  - Tandjaoui-Lambiotte,Y
AU  - Le,Pen J
AU  - Kerner,G
AU  - Bigio,B
AU  - Seeleuthner,Y
AU  - Yang,R
AU  - Bolze,A
AU  - Spaan,AN
AU  - Delmonte,OM
AU  - Abers,MS
AU  - Aiuti,A
AU  - Casari,G
AU  - Lampasona,V
AU  - Piemonti,L
AU  - Ciceri,F
AU  - Bilguvar,K
AU  - Lifton,RP
AU  - Vasse,M
AU  - Smadja,DM
AU  - Migaud,M
AU  - Hadjadj,J
AU  - Terrier,B
AU  - Duffy,D
AU  - Quintana-Murci,L
AU  - van,de Beek D
AU  - Roussel,L
AU  - Vinh,DC
AU  - Tangye,SG
AU  - Haerynck,F
AU  - Dalmau,D
AU  - Martinez-Picado,J
AU  - Brodin,P
AU  - Nussenzweig,MC
AU  - Boisson-Dupuis,S
AU  - Rodríguez-Gallego,C
AU  - Vogt,G
AU  - Mogensen,TH
AU  - Oler,AJ
AU  - Gu,J
AU  - Burbelo,PD
AU  - Cohen,JI
AU  - Biondi,A
AU  - Bettini,LR
AU  - D'Angio,M
AU  - Bonfanti,P
AU  - Rossignol,P
AU  - Mayaux,J
AU  - Rieux-Laucat,F
AU  - Husebye,ES
AU  - Fusco,F
AU  - Ursini,MV
AU  - Imberti,L
AU  - Sottini,A
AU  - Paghera,S
AU  - Quiros-Roldan,E
AU  - Rossi,C
AU  - Castagnoli,R
AU  - Montagna,D
AU  - Licari,A
AU  - Marseglia,GL
AU  - Duval,X
AU  - Ghosn,J
AU  - HGID,Lab
AU  - NIAID-USUHS,Immune Response to COVID Group
AU  - COVID,Clinicians
AU  - COVID-STORM,Clinicians
AU  - Imagine,COVID Group
AU  - French,COVID Cohort Study Group
AU  - Milieu,Intérieur Consortium
AU  - CoV-Contact,Cohort
AU  - Amsterdam,UMC Covid-19 Biobank
AU  - COVID,Human Genetic Effort
AU  - Tsang,JS
AU  - Goldbach-Mansky,R
AU  - Kisand,K
AU  - Lionakis,MS
AU  - Puel,A
AU  - Zhang,S-Y
AU  - Holland,SM
AU  - Gorochov,G
AU  - Jouanguy,E
AU  - Rice,CM
AU  - Cobat,A
AU  - Notarangelo,LD
AU  - Abel,L
AU  - Su,HC
AU  - Casanova,J-L
DO  - 10.1126/science.abd4585
PY  - 2020///
SN  - 1095-9203
TI  - Autoantibodies against type I IFNs in patients with life-threatening COVID-19
T2  - Science
UR  - http://dx.doi.org/10.1126/science.abd4585
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32972996
UR  - https://science.sciencemag.org/content/370/6515/eabd4585
UR  - http://hdl.handle.net/10044/1/85248
VL  - 370
ER  -
Download