Imperial College London
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DrVahidShahrezaei

Faculty of Natural Sciences, Department of Mathematics

Reader in Biomathematics
 
 
 
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Contact

 

+44 (0)20 7594 8516v.shahrezaei Website

 
 
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Location

 

301BSir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kleijn:2022:10.26508/lsa.202101223,
author = {Kleijn, IT and Martínez-Segura, A and Bertaux, F and Saint, M and Kramer, H and Shahrezaei, V and Marguerat, S},
doi = {10.26508/lsa.202101223},
journal = {Life Science Alliance},
title = {Growth-rate dependent and nutrient-specific gene expression resource allocation in fission yeast},
url = {http://dx.doi.org/10.26508/lsa.202101223},
volume = {5},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cellular  resources  are  limited  and  their  relative  allocation  to  gene  expression  programmes determines  physiological  states  and  global  properties  such  as  the  growth  rate.  Here,  we determinedtheimportanceof the growth  rate  in  explaining  relative  changes  in  protein  and mRNA  levels in  the  simple  eukaryote Schizosaccharomyces  pombegrownon  non-limiting nitrogen  sources.  Although expression  of half  of  fission  yeast  genes was significantly correlated with the growth rate, this came alongside wide-spread nutrient-specific regulation. Proteome   and   transcriptome often showed   coordinated   regulation   but   with   notable exceptions,  such  as  metabolic  enzymes. Genes  positively  correlated  with  growth  rate participated  in  every  level  of  protein  production apart  fromRNA  polymerase  II-dependent transcription.Negatively  correlated genes belonged mainly to  the  environmental  stress response  programme.  Critically,  metabolic  enzymes, which represent ~55-70%  of  the proteome  by  mass,showedmostly condition-specificregulation.In  summary,  we  provide  a rich account of resource allocation to gene expression in a simple eukaryote, advancing our 19basic  understanding  of the  interplay  between  growth-rate  dependent  and  nutrient-specific gene expression.
AU  - Kleijn,IT
AU  - Martínez-Segura,A
AU  - Bertaux,F
AU  - Saint,M
AU  - Kramer,H
AU  - Shahrezaei,V
AU  - Marguerat,S
DO  - 10.26508/lsa.202101223
PY  - 2022///
SN  - 2575-1077
TI  - Growth-rate dependent and nutrient-specific gene expression resource allocation in fission yeast
T2  - Life Science Alliance
UR  - http://dx.doi.org/10.26508/lsa.202101223
UR  - http://hdl.handle.net/10044/1/95624
VL  - 5
ER  -
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