Imperial College London
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DrVahidShahrezaei

Faculty of Natural Sciences, Department of Mathematics

Reader in Biomathematics
 
 
 
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Contact

 

+44 (0)20 7594 8516v.shahrezaei Website

 
 
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Location

 

301BSir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Shahrezaei:2015:10.1016/j.mib.2015.05.012,
author = {Shahrezaei, V and Marguerat, S},
doi = {10.1016/j.mib.2015.05.012},
journal = {Current Opinion in Microbiology},
pages = {127--135},
title = {Connecting growth with gene expression: of noise and numbers.},
url = {http://dx.doi.org/10.1016/j.mib.2015.05.012},
volume = {25},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Growth is a dynamic process whereby cells accumulate mass. Growth rates of single cells are connected to RNA and protein synthesis rates, and therefore with biomolecule numbers. Noise in gene expression depends on these numbers, and is thus linked with cellular growth. Whether these global attributes of the cell participate in gene regulation is still largely unexplored. New experimental and modelling studies suggest that systemic variations in biomolecule numbers can coordinate cellular processes, including growth itself, through global regulatory feedback that acts in addition to genetic regulatory networks. Here, we review these findings and speculate on possible implications of this less appreciated layer of gene regulation for cellular physiology and adaptation to changing environments.
AU  - Shahrezaei,V
AU  - Marguerat,S
DO  - 10.1016/j.mib.2015.05.012
EP  - 135
PY  - 2015///
SN  - 1879-0364
SP  - 127
TI  - Connecting growth with gene expression: of noise and numbers.
T2  - Current Opinion in Microbiology
UR  - http://dx.doi.org/10.1016/j.mib.2015.05.012
UR  - http://hdl.handle.net/10044/1/24794
VL  - 25
ER  -
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