Imperial College London


Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Clinical Reader in Obstetrics and Gynaecology



+44 (0)20 7594 2164v.terzidou




Institute of Reproductive and Developmental BiologyHammersmith Campus






Vasso Terzidou is a Clinical Reader (Associate Professor) in Obstetrics and Gynaecology and a Consultant in Obstetrics and Gynaecology at Chelsea & Westminster Hospital. 

She leads the prematurity services for Chelsea & Westminster Hospital in London and her principal research interests are the biochemistry and endocrinology of human labour and the prediction and prevention of preterm birth and adverse pregnancy outcomes.

The principal areas of her research are examining

-Causes underlying uterine biology leading to adverse pregnancy outcomes such as preterm delivery and fetal growth disorders.

-Investigation of circulating microRNAs and their diagnostic application for preterm birth prediction as well as understanding the mechanism by which uterine microRNAs can modulate inflammatory pathways in the uterus.

-Investigation of circulating microRNAs and their diagnostic application for early identification of other pregnancy complications such as growth restriction.

-Investigation of circulating microRNAs and their diagnostic application for early identification of miscarriages, pregnancies of unknown location and ectopic pregnancies

-Collaboration with Imperial College Bioengineering Department for the development of a bedside test for detection of circulating miRNAs to predict pregnancy complications.

-Large-scale validation studies of miRNA biomarkers for early detection of subsequent preterm birth in low-risk population.

-OT/OT receptor modulation for management of term and preterm labour.

-GPCR activity in pregnancy and labour, including interactions of oxytocin and prostaglandin receptors to identify a multi-target therapeutic strategy that controls myometrial contractility and uterine inflammation.

-Development and testing of novel tocolytics through industrial collaboration partnerships.

MicroRNA Biomarkers to predict adverse pregnancy outcomes theme

  • Early identification of circulating microRNAs in blood that are highly predictive of subsequent preterm birth and cervical shortening (European and International Patent granted). There is an urgent need for a test to predict women who will subsequently deliver preterm. These women can receive targeted antenatal surveillance and prophylactic interventions. (ie progesterone or cervical cerclage).
  • Identification of circulating microRNAs able to predict pregnancy complications such as growth restriction (Patent granted)
  • Identification of circulating microRNAs able to differentiate early pregnancy complications such as miscarriages, pregnancies of unknown location and ectopic pregnancies (Patent filed)
  • Collaboration with Imperial Bioengineering Department (Dr Sylvain Ladame) to develop a bedside miRNA detection test to predict adverse pregnancy outcomes.
  • Currently conducting large-scale validation studies of microRNAs biomarkers of preterm birth in a low-risk population with 3800 women recruited (PROPER study- funded by March of Dimes).
  • Collaboration with Professor Henrik Hagberg- a validation study of microRNAs biomarkers of preterm birth in a Swedish cohort of low-risk women (11036 women with 411 women delivering <37 weeks).
  • Currently conducting large-scale validation of miRNA biomarkers for prediction of SGA babies.
  • Validation of miRNA biomarkers for prediction of miscarriages, ectopic pregnancies, and early pregnancy complications (Collaboration with Professor Tom Bourne)
  • Functional studies to define the origin and understand the biological basis of action for these miRNA biomarkers.

Uterine Biology- GPCR-OT/OTR function

OTR/PG interactions and discovery of novel tocolytics

  • OT/OTR has a well-defined role in stimulating uterine contractions via calcium signalling and my work has demonstrated of a novel pro-inflammatory role for oxytocin driving the sequential activation of MAPKs and NF-κB via OTR-Gαi coupling. Atosiban (an OTR antagonist-currently used as a tocolytic) activates pro- inflammatory pathways and this could have an effect upon the fetus in preterm labour in the presence of chorioamnionitis.
  • Her work has provided initial evidence of OTR dimerization/ oligomerization. An interaction via crosstalk mechanism between OTR and PG receptors is important in GPCR biology as it can facilitate identification of multi-target therapeutic strategies for preterm labour and labour induction. 

Selected Publications

Journal Articles

Pohl O, Chollét A, Kim SH, et al., 2018, OBE022, an oral and selective prostaglandin F2α receptor antagonist as an effective and safe modality for the treatment of preterm labor, Journal of Pharmacology and Experimental Therapeutics, ISSN:0022-3565

Cook JR, Chatfield S, Chandiramani M, et al., 2017, Cerclage position, cervical length and preterm delivery in women undergoing ultrasound indicated cervical cerclage: A retrospective cohort study, PLOS One, Vol:12, ISSN:1932-6203

Kim SH, Pohl O, Chollet A, et al., 2017, Differential Effects of Oxytocin Receptor Antagonists, Atosiban and Nolasiban, on Oxytocin Receptor-Mediated Signaling in Human Amnion and Myometrium, Molecular Pharmacology, Vol:91, ISSN:0026-895X, Pages:403-415

Kindinger LM, Kyrgiou M, MacIntyre DA, et al., 2016, Preterm Birth Prevention Post-Conization: A Model of Cervical Length Screening with Targeted Cerclage, PLOS One, Vol:11, ISSN:1932-6203

Nawathe AR, Christian M, Kim SH, et al., 2016, Insulin-like growth factor axis in pregnancies affected by fetal growth disorders, Clinical Epigenetics, Vol:8, ISSN:1868-7083

Kim SH, MacIntyre DA, Hanyaloglu AC, et al., 2015, The oxytocin receptor antagonist, Atosiban, activates pro-inflammatory pathways in human amnion via G(alpha i) signalling, Molecular and Cellular Endocrinology, Vol:420, ISSN:1872-8057, Pages:11-23

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