Imperial College London
Alternate

ProfessorVictorTybulewicz

Faculty of Medicine, Department of Immunology and Inflammation

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3796 1612v.tybulewicz Website CV

 
 
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Location

 

L2-2720Francis Crick InstituteThe Francis Crick Institute

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Summary

 

Publications

Citation

BibTex format

@article{Perez-Mazliah:2018:10.7554/eLife.39800,
author = {Perez-Mazliah, D and Gardner, PJ and Schweighoffer, E and McLaughlin, S and Hosking, C and Tumwine, I and Davis, RS and Potocnik, AJ and Tybulewicz, VLJ and Langhorne, J},
doi = {10.7554/eLife.39800},
journal = {eLife},
title = {Plasmodium-specific atypical memory B cells are short-lived activated B cells},
url = {http://dx.doi.org/10.7554/eLife.39800},
volume = {7},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A subset of atypical memory B cells accumulates in malaria and several infections, autoimmune disorders and aging in both humans and mice. It has been suggested these cells are exhausted long-lived memory B cells, and their accumulation may contribute to poor acquisition of long-lasting immunity to certain chronic infections, such as malaria and HIV. Here, we generated an immunoglobulin heavy chain knock-in mouse with a BCR that recognizes MSP1 of the rodent malaria parasite, Plasmodium chabaudi. In combination with a mosquito-initiated P. chabaudi infection, we show that Plasmodium-specific atypical memory B cells are short-lived and disappear upon natural resolution of chronic infection. These cells show features of activation, proliferation, DNA replication, and plasmablasts. Our data demonstrate that Plasmodium-specific atypical memory B cells are not a subset of long-lived memory B cells, but rather short-lived activated cells, and part of a physiologic ongoing B-cell response.
AU  - Perez-Mazliah,D
AU  - Gardner,PJ
AU  - Schweighoffer,E
AU  - McLaughlin,S
AU  - Hosking,C
AU  - Tumwine,I
AU  - Davis,RS
AU  - Potocnik,AJ
AU  - Tybulewicz,VLJ
AU  - Langhorne,J
DO  - 10.7554/eLife.39800
PY  - 2018///
SN  - 2050-084X
TI  - Plasmodium-specific atypical memory B cells are short-lived activated B cells
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.39800
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000450547900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/66160
VL  - 7
ER  -
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