Imperial College London
Alternate

ProfessorVictorTybulewicz

Faculty of Medicine, Department of Immunology and Inflammation

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3796 1612v.tybulewicz Website CV

 
 
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Location

 

L2-2720Francis Crick InstituteThe Francis Crick Institute

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Summary

 

Publications

Citation

BibTex format

@article{Hithersay:2018:10.1001/jamaneurol.2018.3616,
author = {Hithersay, R and Startin, CM and Hamburg, S and Mok, KY and Hardy, J and Fisher, EMC and Tybulewicz, VLJ and Nizetic, D and Strydom, A},
doi = {10.1001/jamaneurol.2018.3616},
journal = {JAMA Neurology},
pages = {152--160},
title = {Association of dementia with mortality among adults with down syndrome older than 35 years},
url = {http://dx.doi.org/10.1001/jamaneurol.2018.3616},
volume = {76},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Importance: This work quantifies the fatal burden of dementia associated with Alzheimer disease in individuals with Down syndrome (DS). Objective: To explore the association of dementia associated with Alzheimer disease with mortality and examine factors associated with dementia in adults with DS. Design, Settings and Participants: Prospective longitudinal study in a community setting in England. Data collection began March 29, 2012. Cases were censored on December 13, 2017. The potential sample consisted of all adults 36 years and older from the London Down Syndrome Consortium cohort with 2 data times and dementia status recorded (N = 300); 6 withdrew from study, 28 were lost to follow-up, and 55 had a single data collection point at time of analysis. The final sample consisted of 211 participants, with 503.92 person-years' follow-up. Exposures: Dementia status, age, sex, APOE genotype, level of intellectual disability, health variables, and living situation. Main Outcomes and Measures: Crude mortality rates, time to death, and time to dementia diagnosis with proportional hazards of predictors. Results: Of the 211 participants, 96 were women (45.5%) and 66 (31.3%) had a clinical dementia diagnosis. Twenty-seven participants (11 female; mean age at death, 56.74 years) died during the study period. Seventy percent had dementia. Crude mortality rates for individuals with dementia (1191.85 deaths per 10000 person-years; 95% CI, 1168.49-1215.21) were 5 times higher than for those without (232.22 deaths per 10000 person-years; 95% CI, 227.67-236.77). For those with dementia, APOE ε4 carriers had a 7-fold increased risk of death (hazard ratio [HR], 6.91; 95% CI, 1.756-27.195). For those without dementia, epilepsy with onset after age 36 years was associated with mortality (HR, 9.66; 95% CI, 1.59-58.56). APOE ε4 carriers (HR, 4.91; 95% CI, 2.53-9.56), adults with early-onset epilepsy (HR, 3.61; 95% CI, 1.12-11.60), multiple health comorbidit
AU  - Hithersay,R
AU  - Startin,CM
AU  - Hamburg,S
AU  - Mok,KY
AU  - Hardy,J
AU  - Fisher,EMC
AU  - Tybulewicz,VLJ
AU  - Nizetic,D
AU  - Strydom,A
DO  - 10.1001/jamaneurol.2018.3616
EP  - 160
PY  - 2018///
SN  - 2168-6149
SP  - 152
TI  - Association of dementia with mortality among adults with down syndrome older than 35 years
T2  - JAMA Neurology
UR  - http://dx.doi.org/10.1001/jamaneurol.2018.3616
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30452522
UR  - https://jamanetwork.com/journals/jamaneurology/fullarticle/2714719
UR  - http://hdl.handle.net/10044/1/64836
VL  - 76
ER  -
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