Imperial College London
Alternate

ProfessorVictorTybulewicz

Faculty of Medicine, Department of Immunology and Inflammation

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3796 1612v.tybulewicz Website CV

 
 
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Location

 

L2-2720Francis Crick InstituteThe Francis Crick Institute

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Summary

 

Publications

Citation

BibTex format

@article{Köchl:2020:10.1101/2020.06.11.147017,
author = {Köchl, R and Vanes, L and Sopena, ML and Chakravarty, P and Hartweger, H and Fountain, K and White, A and Cowan, J and Anderson, G and Tybulewicz, VLJ},
doi = {10.1101/2020.06.11.147017},
title = {Critical role of WNK1 in MYC-dependent early thymocyte development},
url = {http://dx.doi.org/10.1101/2020.06.11.147017},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>WNK1, a kinase that controls kidney salt homeostasis, also regulates adhesion and migration in CD4<jats:sup>+</jats:sup>T cells.<jats:italic>Wnk1</jats:italic>is highly expressed in thymocytes, and since migration is important for thymocyte maturation, we investigated a role for WNK1 in thymocyte development. We find that WNK1 is required for the transition of double negative (DN) thymocytes through the β-selection checkpoint and subsequent proliferation and differentiation into double positive (DP) thymocytes. Furthermore, we show that WNK1 negatively regulates LFA1-mediated adhesion and positively regulates CXCL12-induced migration in DN thymocytes. Despite this, migration defects of WNK1-deficient thymocytes do not account for the developmental arrest. Instead, we show that in DN thymocytes WNK1 transduces pre-TCR signals via OXSR1 and STK39 kinases and the SLC12A2 ion co-transporter that are required for post-transcriptional upregulation of MYC and subsequent proliferation and differentiation into DP thymocytes. Thus, a pathway regulating ion homeostasis is a critical regulator of thymocyte development.</jats:p>
AU  - Köchl,R
AU  - Vanes,L
AU  - Sopena,ML
AU  - Chakravarty,P
AU  - Hartweger,H
AU  - Fountain,K
AU  - White,A
AU  - Cowan,J
AU  - Anderson,G
AU  - Tybulewicz,VLJ
DO  - 10.1101/2020.06.11.147017
PY  - 2020///
TI  - Critical role of WNK1 in MYC-dependent early thymocyte development
UR  - http://dx.doi.org/10.1101/2020.06.11.147017
ER  -
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