Imperial College London
Alternate

ProfessorVictorTybulewicz

Faculty of Medicine, Department of Immunology and Inflammation

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3796 1612v.tybulewicz Website CV

 
 
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Location

 

L2-2720Francis Crick InstituteThe Francis Crick Institute

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Summary

 

Publications

Citation

BibTex format

@article{Schweighoffer:2021:10.1016/j.coi.2021.06.014,
author = {Schweighoffer, E and Tybulewicz, VL},
doi = {10.1016/j.coi.2021.06.014},
journal = {Current Opinion in Immunology},
pages = {124--131},
title = {BAFF signaling in health and disease.},
url = {http://dx.doi.org/10.1016/j.coi.2021.06.014},
volume = {71},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BAFF is a critical cytokine supporting the survival of mature naïve B cells, acting through the BAFFR receptor. Recent studies show that BAFF and BAFFR are also required for the survival of memory B cells, autoimmune B cells as well as malignant chronic lymphocytic leukaemia (CLL) cells. BAFFR cooperates with other receptors, notably the B cell antigen receptor (BCR), a process which is critical for the expansion of autoimmune and CLL cells. This crosstalk may be mediated by TRAF3 which interacts with BAFFR and with CD79A, a signalling subunit of the BCR and the downstream SYK kinase, inhibiting its activity. BAFF binding to BAFFR leads to degradation of TRAF3 which may relieve inhibition of SYK activity transducing signals to pathways required for B cell survival. BAFFR activates both canonical and non-canonical NF-κB signalling and both pathways play important roles in the survival of B cells and CLL cells.
AU  - Schweighoffer,E
AU  - Tybulewicz,VL
DO  - 10.1016/j.coi.2021.06.014
EP  - 131
PY  - 2021///
SN  - 0952-7915
SP  - 124
TI  - BAFF signaling in health and disease.
T2  - Current Opinion in Immunology
UR  - http://dx.doi.org/10.1016/j.coi.2021.06.014
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34352467
UR  - https://www.sciencedirect.com/science/article/pii/S0952791521000832?via%3Dihub
UR  - http://hdl.handle.net/10044/1/90994
VL  - 71
ER  -
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