Imperial College London
Dr Victoria Wright

DrVictoriaWright

Faculty of Medicine, Department of Infectious Disease

Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 3577v.wright

 
 
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Location

 

PaediatricsMedical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nagelkerke:2019:10.3389/fimmu.2019.00185,
author = {Nagelkerke, SQ and Tacke, CE and Breunis, WB and Tanck, MWT and Geissler, J and Png, E and Hoang, LT and van, der Heijden J and Naim, ANM and Yeung, RSM and Levin, ML and Wright, VJ and Burgner, DP and Ponsonby, A-L and Ellis, JA and Cimaz, R and Shimizu, C and Burns, JC and Fijnyandraat, K and van, der Schoot CE and van, den Berg TK and de, Boer M and Davila, S and Hibberd, ML and Kuijpers, TW and Dahdah, N and Kone-Paut, I},
doi = {10.3389/fimmu.2019.00185},
journal = {Frontiers in Immunology},
title = {Extensive ethnic variation and linkage disequilibrium at the FCGR2/3 locus: Different genetic associations revealed in Kawasaki Disease},
url = {http://dx.doi.org/10.3389/fimmu.2019.00185},
volume = {10},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The human Fc-gamma receptors (FcγRs) link adaptive and innate immunity by binding immunoglobulin G (IgG). All human low-affinity FcγRs are encoded by the FCGR2/3 locus containing functional single nucleotide polymorphisms (SNPs) and gene copy number variants. This locus is notoriously difficult to genotype and high-throughput methods commonly used focus on only a few SNPs. We performed multiplex ligation-dependent probe amplification for all relevant genetic variations at the FCGR2/3 locus in >4,000 individuals to define linkage disequilibrium (LD) and allele frequencies in different populations. Strong LD and extensive ethnic variation in allele frequencies was found across the locus. LD was strongest for the FCGR2C-ORF haplotype (rs759550223+rs76277413), which leads to expression of FcγRIIc. In Europeans, the FCGR2C-ORF haplotype showed strong LD with, among others, rs201218628 (FCGR2A-Q27W, r2 = 0.63). LD between these two variants was weaker (r2 = 0.17) in Africans, whereas the FCGR2C-ORF haplotype was nearly absent in Asians (minor allele frequency <0.005%). The FCGR2C-ORF haplotype and rs1801274 (FCGR2A-H131R) were in weak LD (r2 = 0.08) in Europeans. We evaluated the importance of ethnic variation and LD in Kawasaki Disease (KD), an acute vasculitis in children with increased incidence in Asians. An association of rs1801274 with KD was previously shown in ethnically diverse genome-wide association studies. Now, we show in 1,028 European KD patients that the FCGR2C-ORF haplotype, although nearly absent in Asians, was more strongly associated with susceptibility to KD than rs1801274 in Europeans. Our data illustrate the importance of interpreting findings of association studies concerning the FCGR2/3 locus with knowledge of LD and ethnic variation.
AU  - Nagelkerke,SQ
AU  - Tacke,CE
AU  - Breunis,WB
AU  - Tanck,MWT
AU  - Geissler,J
AU  - Png,E
AU  - Hoang,LT
AU  - van,der Heijden J
AU  - Naim,ANM
AU  - Yeung,RSM
AU  - Levin,ML
AU  - Wright,VJ
AU  - Burgner,DP
AU  - Ponsonby,A-L
AU  - Ellis,JA
AU  - Cimaz,R
AU  - Shimizu,C
AU  - Burns,JC
AU  - Fijnyandraat,K
AU  - van,der Schoot CE
AU  - van,den Berg TK
AU  - de,Boer M
AU  - Davila,S
AU  - Hibberd,ML
AU  - Kuijpers,TW
AU  - Dahdah,N
AU  - Kone-Paut,I
DO  - 10.3389/fimmu.2019.00185
PY  - 2019///
SN  - 1664-3224
TI  - Extensive ethnic variation and linkage disequilibrium at the FCGR2/3 locus: Different genetic associations revealed in Kawasaki Disease
T2  - Frontiers in Immunology
UR  - http://dx.doi.org/10.3389/fimmu.2019.00185
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000461855100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/69809
VL  - 10
ER  -
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