Imperial College London
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MrVanashPatel

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

vanash.patel06

 
 
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Location

 

1089Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kidher:2014:2014/970793,
author = {Kidher, E and Patel, VM and Nihoyannopoulos, P and Anderson, JR and Chukwuemeka, A and Francis, DP and Ashrafian, H and Athanasiou, T},
doi = {2014/970793},
journal = {Neurology Research International},
title = {Aortic stiffness is related to the ischemic brain injury biomarker N-methyl-D-aspartate receptor antibody levels in aortic valve replacement},
url = {http://dx.doi.org/10.1155/2014/970793},
volume = {2014},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background. Aortic stiffness changes the flow pattern of circulating blood causing microvascular damage to different end-organ tissues, such as brain cells. The relationship between aortic stiffness measured by pulse wave velocity (PWV) and serum ischemic brain injury biomarker N-methyl-D-aspartate receptor antibody (NR2Ab) levels in aortic valve replacement has not been assessed. Methods. Patients undergoing aortic valve replacement (AVR) for aortic stenosis (AS) had their PWV and NR2Ab serum levels measured preoperatively. We analyzed PWV and NR2Ab in two ways: (1) as continuous variables using the actual value and (2) as dichotomous variables (PWV-norm and PWV-high groups) and (NR2Ab-low and NR2Ab-high groups). Results. Fifty-six patients ( years) were included in this study. The NR2Ab level (ng/mL) was significantly higher in the PWV-high group () than in PWV-norm group (; median versus , resp., ). NR2Ab level was positively associated with PWV and negatively associated with male gender. Multiple regression revealed PWV independently related to NR2Ab level, and PWV cut-off was associated with a 7.23 times increase in the likelihood of having high NR2Ab (>1.8 ng/mL). Conclusion. Higher PWV in patients with surgical aortic stenosis is associated with higher levels of the ischemic brain biomarker NR2Ab.
AU  - Kidher,E
AU  - Patel,VM
AU  - Nihoyannopoulos,P
AU  - Anderson,JR
AU  - Chukwuemeka,A
AU  - Francis,DP
AU  - Ashrafian,H
AU  - Athanasiou,T
DO  - 2014/970793
PY  - 2014///
SN  - 2090-1860
TI  - Aortic stiffness is related to the ischemic brain injury biomarker N-methyl-D-aspartate receptor antibody levels in aortic valve replacement
T2  - Neurology Research International
UR  - http://dx.doi.org/10.1155/2014/970793
UR  - http://hdl.handle.net/10044/1/33204
VL  - 2014
ER  -
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